Size effect of colloidal selenium particles on the inhibition of LPS-induced nitric oxide production

Yue-Hwa Chen, H. P. Chang, Zong Hong Lin, C. R Chris Wang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We have stud led the size-dependent inhibition capabilities of colloidal selenium (Se) particles on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 cells. Four particle sizes of the nano-Se, ranging from 45-220 nm in diameter, were examined. All of them, unlike their bulk material, show clear capabilities of inhibition and a trend dependent on the particles size. The inhbition be comes more potent as the particle size in creases. It indicates that pursuing the reduction of colloidal sizes into nanoscale is not favoured in this biological system.

Original languageEnglish
Pages (from-to)389-393
Number of pages5
JournalJournal of the Chinese Chemical Society
Volume52
Issue number3
Publication statusPublished - 2005

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Keywords

  • NO radical inhibition
  • Selenium nanoparticles
  • Size-dependence

ASJC Scopus subject areas

  • Chemistry(all)

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