Sixteen years post radiotherapy of nasopharyngeal carcinoma elicited multi-dysfunction along PTX and chronic kidney disease with microcytic anemia

Yi Ting Lin, Chia Chun Huang, Charng Cherng Chyau, Kuan Chou Chen, Robert Y. Peng

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5 Citations (Scopus)


Background: The hypothalamic-pituitary (h-p) unit is a particularly radiosensitive region in the central nervous system. As a consequence, radiation-induced irreversible, progressively chronic onset hypopituitarism (RIH) commonly develops after radiation treatments and can result in variably impaired pituitary function, which is frequently associated with increased morbidity and mortality. Case presentation. A 38-year-old male subject, previously having received radiotherapy for treatment of nasopharygeal carcinoma (NPCA) 16 years ago, appeared at OPD complaining about his failure in penile erection, loss of pubic hair, atrophy of external genitalia: testicles reduced to 2×1.5 cm; penile size shrunk to only 4 cm long. Characteristically, he showed extremely lowered human growth hormone, (HGH, 0.115 ng/mL), testosterone (

Original languageEnglish
Article number19
JournalBMC Urology
Issue number1
Publication statusPublished - Feb 12 2014



  • Adrenal insufficiency
  • Chronic kidney disease
  • Hypogonadism
  • Hypopituitarism
  • Hypothyroidism
  • Microcytic anemia
  • Radiotherapy

ASJC Scopus subject areas

  • Urology
  • Reproductive Medicine

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