Six-month nocturnal nasal positive pressure ventilation improves respiratory muscle capacity and exercise endurance in patients with chronic hypercapnic respiratory failure

Ling Ling Chiang, Chih Teng Yu, Chien Ying Liu, Yu Lun Lo, Han Pin Kuo, Horng Chyuan Lin

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Background/Purpose: This study was designed to investigate the effects of 6 months of nocturnal nasal positive pressure ventilation (NNPPV) on respiratory muscle function and exercise capacity in patients with chronic respiratory failure. Methods: A prospective, randomized, controlled design was used. Twenty-nine patients with chronic respiratory failure were enrolled and allocated to either the NNPPV (n = 14) or control group (n = 15). Patients in the NNPPV group received bi-level positive pressure ventilation via nasal mask for 6 consecutive months. Arterial blood gas, respiratory muscle assessment and 6-minute walk test (6MWT) were performed before and after the 6-month NNPPV intervention. Respiratory muscle function was assessed using the variables of maximal inspiratory pressure (Pimax), maximal expiratory pressure (Pemax), and maximum voluntary ventilation (MVV). Results: Subjects in the NNPPV group showed a significant improvement in blood gas exchange and increased 6-minute walk distance (6MWD) compared to baseline and the control group. The 6MWD was significantly increased from 257.1 ± 114.1 to 345.2 ± 109.9 m (34.3%) in the NNPPV group. NNPPV also significantly improved MVV and Pimax relative to baseline. MVV was significantly increased from 19.2 ± 6.5 to 22.3 ± 7.1 L/min (16.1%) in the NNPPV group (p <0.05). Furthermore, there was a significant correlation between the magnitude of MVV improvement and 6MWD change. Conclusion: The 6-month NNPPV treatment significantly decreased the partial pressure of carbon dioxide and improved daytime respiratory muscle function, thus contributing to exercise-capacity increase in patients with chronic respiratory failure.

Original languageEnglish
Pages (from-to)459-467
Number of pages9
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume105
Issue number6
Publication statusPublished - Jun 2006

Keywords

  • 6-minute walk test
  • Chronic respiratory failure
  • Nocturnal nasal positive pressure ventilation
  • Respiratory muscle function

ASJC Scopus subject areas

  • Medicine(all)

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