SITES OF SKULL BASE INVASION AS PREDICTORS OF INTRACRANIAL EXTENSION IN NASOPHARYNGEAL CARCINOMA AND ITS IMPACT ON THE TREATMENT OUTCOME

許 維中(Wei-Chung Hsu), 陳 宇嘉(Yu-Chia Chen), 丁 禮莉(Lai-Lei Ting), 鍾 娜娜(Na-Na Chung), 王 博民(Po-Ming Wang), 陳 斯榮(Szu-Jung Chen)

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the influence of skull base abnormality on prognosis and correlation with intracranial invasion in nasopharyngeal carcinoma (NPC) patients. Materials and Methods: Total 812 consecutive patients with histologically confirmed NPC who underwent staging computerized tomography and magnetic resonance imaging for evaluation of primary tumor extension were enrolled in this study. All radiologic images were reviewed and assessed for intracranial extension and skull base invasion. Results: Tumor invasion of the foramen ovale, petrous portion of the temporal bone, clivus and the pterygopalatine fossa associated with intracranial involvement. The number in site of skull base lesions showed significant differences in local failure-free survival. Foramen ovale, petrous portion of the temporal bone and pterygopalatine fossa involvement also showed impact on local failure-free survival. Conclusions: Involvement of the skull base such as foramen ovale, petrous portion of the temporal bone, clivus, and pterygopalatine fossa could be good predictors of intracranial involvement in NPC and all except clivus affected local failure-free survival.
Original languageEnglish
Pages (from-to)85-95
Number of pages11
Journal放射治療與腫瘤學
Volume24
Issue number2
DOIs
Publication statusPublished - 2017

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Pterygopalatine Fossa
Skull Base
Foramen Ovale
Posterior Cranial Fossa
Temporal Bone
Survival
Neoplasms
Tomography
Magnetic Resonance Imaging
Nasopharyngeal carcinoma

Keywords

  • Intracranial involvement
  • Magnetic resonance imaging
  • Nasopharyngeal carcinoma
  • Skull base invasion
  • Survival
  • 腦內蔓延
  • 磁振攝影
  • 鼻咽癌
  • 顱底侵犯
  • 存活率

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SITES OF SKULL BASE INVASION AS PREDICTORS OF INTRACRANIAL EXTENSION IN NASOPHARYNGEAL CARCINOMA AND ITS IMPACT ON THE TREATMENT OUTCOME. / 許維中(Wei-Chung Hsu); 陳宇嘉(Yu-Chia Chen); 丁禮莉(Lai-Lei Ting); 鍾娜娜(Na-Na Chung); 王博民(Po-Ming Wang); 陳斯榮(Szu-Jung Chen).

In: 放射治療與腫瘤學, Vol. 24, No. 2, 2017, p. 85-95.

Research output: Contribution to journalArticle

許維中(Wei-Chung Hsu) ; 陳宇嘉(Yu-Chia Chen) ; 丁禮莉(Lai-Lei Ting) ; 鍾娜娜(Na-Na Chung) ; 王博民(Po-Ming Wang) ; 陳斯榮(Szu-Jung Chen). / SITES OF SKULL BASE INVASION AS PREDICTORS OF INTRACRANIAL EXTENSION IN NASOPHARYNGEAL CARCINOMA AND ITS IMPACT ON THE TREATMENT OUTCOME. In: 放射治療與腫瘤學. 2017 ; Vol. 24, No. 2. pp. 85-95.
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abstract = "Purpose: To evaluate the influence of skull base abnormality on prognosis and correlation with intracranial invasion in nasopharyngeal carcinoma (NPC) patients. Materials and Methods: Total 812 consecutive patients with histologically confirmed NPC who underwent staging computerized tomography and magnetic resonance imaging for evaluation of primary tumor extension were enrolled in this study. All radiologic images were reviewed and assessed for intracranial extension and skull base invasion. Results: Tumor invasion of the foramen ovale, petrous portion of the temporal bone, clivus and the pterygopalatine fossa associated with intracranial involvement. The number in site of skull base lesions showed significant differences in local failure-free survival. Foramen ovale, petrous portion of the temporal bone and pterygopalatine fossa involvement also showed impact on local failure-free survival. Conclusions: Involvement of the skull base such as foramen ovale, petrous portion of the temporal bone, clivus, and pterygopalatine fossa could be good predictors of intracranial involvement in NPC and all except clivus affected local failure-free survival.",
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author = "許, {維中(Wei-Chung Hsu)} and 陳, {宇嘉(Yu-Chia Chen)} and 丁, {禮莉(Lai-Lei Ting)} and 鍾, {娜娜(Na-Na Chung)} and 王, {博民(Po-Ming Wang)} and 陳, {斯榮(Szu-Jung Chen)}",
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AU - 許, 維中(Wei-Chung Hsu)

AU - 陳, 宇嘉(Yu-Chia Chen)

AU - 丁, 禮莉(Lai-Lei Ting)

AU - 鍾, 娜娜(Na-Na Chung)

AU - 王, 博民(Po-Ming Wang)

AU - 陳, 斯榮(Szu-Jung Chen)

PY - 2017

Y1 - 2017

N2 - Purpose: To evaluate the influence of skull base abnormality on prognosis and correlation with intracranial invasion in nasopharyngeal carcinoma (NPC) patients. Materials and Methods: Total 812 consecutive patients with histologically confirmed NPC who underwent staging computerized tomography and magnetic resonance imaging for evaluation of primary tumor extension were enrolled in this study. All radiologic images were reviewed and assessed for intracranial extension and skull base invasion. Results: Tumor invasion of the foramen ovale, petrous portion of the temporal bone, clivus and the pterygopalatine fossa associated with intracranial involvement. The number in site of skull base lesions showed significant differences in local failure-free survival. Foramen ovale, petrous portion of the temporal bone and pterygopalatine fossa involvement also showed impact on local failure-free survival. Conclusions: Involvement of the skull base such as foramen ovale, petrous portion of the temporal bone, clivus, and pterygopalatine fossa could be good predictors of intracranial involvement in NPC and all except clivus affected local failure-free survival.

AB - Purpose: To evaluate the influence of skull base abnormality on prognosis and correlation with intracranial invasion in nasopharyngeal carcinoma (NPC) patients. Materials and Methods: Total 812 consecutive patients with histologically confirmed NPC who underwent staging computerized tomography and magnetic resonance imaging for evaluation of primary tumor extension were enrolled in this study. All radiologic images were reviewed and assessed for intracranial extension and skull base invasion. Results: Tumor invasion of the foramen ovale, petrous portion of the temporal bone, clivus and the pterygopalatine fossa associated with intracranial involvement. The number in site of skull base lesions showed significant differences in local failure-free survival. Foramen ovale, petrous portion of the temporal bone and pterygopalatine fossa involvement also showed impact on local failure-free survival. Conclusions: Involvement of the skull base such as foramen ovale, petrous portion of the temporal bone, clivus, and pterygopalatine fossa could be good predictors of intracranial involvement in NPC and all except clivus affected local failure-free survival.

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KW - Magnetic resonance imaging

KW - Nasopharyngeal carcinoma

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KW - Survival

KW - 腦內蔓延

KW - 磁振攝影

KW - 鼻咽癌

KW - 顱底侵犯

KW - 存活率

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JO - 放射治療與腫瘤學

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ER -