Sitagliptin modulates the electrical and mechanical characteristics of pulmonary vein and atrium

Chien Jung Chang, Ten Fang Yang, Tin I. Lee, Yao Chang Chen, Yu Hsun Kao, Shih Ann Chen, Yi Jen Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The pulmonary veins (PVs) and atria are important foci during that period when atrial fibrillation (AF) is generated and maintained. It is well understood that hypertension and diabetesmellitus (DM) are important risk factors for AF. Dipeptidyl peptidase-IV (DPP-4) inhibitors are newagents in the fight against type 2 DM, though they have been found to have several cardiovascular effects. However, it is not clear whether DPP-4 may modulate the electrical and mechanical characteristics in hypertensive atrium or PVs. Methods: Conventional microelectrodes were used to record the action potentials (APs) in isolated PVs, right atrium (RA), and left atrium (LA) in Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) with or without sitagliptin (10 mg/kg) for 4 weeks. Results: WKY ( n = 5), SHR ( n = 7), sitagliptin-treated WKY ( n = 5) and sitagliptin-treated SHR ( n = 7) had similar PV or sinoatrial spontaneous beating rates. However, the sitagliptin-treated WKY had fewer sinoatrial-PV beating rate differences than WKY, SHR or sitagliptin-treated SHR. WKY and SHR had shorter 90% (APD 90) of RA AP duration than sitagliptin-treated WKY or sitagliptin-treated SHR. In contrast, WKY had longer LA APD90 than sitagliptin-treated WKY, but SHR and sitagliptin-treated SHR had similar LA APD90. Sitagliptin-treated WKY or sitagliptin-treated SHR had larger (RA-LA) APD90 differences than WKY or SHR, respectively. Moreover, as compared to WKY the post-rest potentiation of contraction was decreased in SHR, sitagliptin-treated WKY, and sitagliptin-treated SHR. Conclusions: Sitagliptin significantly affects the electromechanical characteristics of PVs and atria, which can be modulated by hypertension.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalActa Cardiologica Sinica
Volume30
Issue number1
Publication statusPublished - 2014

Fingerprint

Pulmonary Veins
Inbred WKY Rats
Inbred SHR Rats
Heart Atria
pamidronate
Sitagliptin Phosphate
Atrial Fibrillation
Action Potentials
Hypertension
Dipeptidyl Peptidase 4
Microelectrodes

Keywords

  • Atrial fibrillation
  • Atrium
  • Dipeptidyl peptidase inhibitor-4
  • Hypertension
  • Pulmonary vein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sitagliptin modulates the electrical and mechanical characteristics of pulmonary vein and atrium. / Chang, Chien Jung; Yang, Ten Fang; Lee, Tin I.; Chen, Yao Chang; Kao, Yu Hsun; Chen, Shih Ann; Chen, Yi Jen.

In: Acta Cardiologica Sinica, Vol. 30, No. 1, 2014, p. 29-37.

Research output: Contribution to journalArticle

Chang, Chien Jung ; Yang, Ten Fang ; Lee, Tin I. ; Chen, Yao Chang ; Kao, Yu Hsun ; Chen, Shih Ann ; Chen, Yi Jen. / Sitagliptin modulates the electrical and mechanical characteristics of pulmonary vein and atrium. In: Acta Cardiologica Sinica. 2014 ; Vol. 30, No. 1. pp. 29-37.
@article{a88dc199425f4649a6f84eb052d40acf,
title = "Sitagliptin modulates the electrical and mechanical characteristics of pulmonary vein and atrium",
abstract = "Background: The pulmonary veins (PVs) and atria are important foci during that period when atrial fibrillation (AF) is generated and maintained. It is well understood that hypertension and diabetesmellitus (DM) are important risk factors for AF. Dipeptidyl peptidase-IV (DPP-4) inhibitors are newagents in the fight against type 2 DM, though they have been found to have several cardiovascular effects. However, it is not clear whether DPP-4 may modulate the electrical and mechanical characteristics in hypertensive atrium or PVs. Methods: Conventional microelectrodes were used to record the action potentials (APs) in isolated PVs, right atrium (RA), and left atrium (LA) in Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) with or without sitagliptin (10 mg/kg) for 4 weeks. Results: WKY ( n = 5), SHR ( n = 7), sitagliptin-treated WKY ( n = 5) and sitagliptin-treated SHR ( n = 7) had similar PV or sinoatrial spontaneous beating rates. However, the sitagliptin-treated WKY had fewer sinoatrial-PV beating rate differences than WKY, SHR or sitagliptin-treated SHR. WKY and SHR had shorter 90{\%} (APD 90) of RA AP duration than sitagliptin-treated WKY or sitagliptin-treated SHR. In contrast, WKY had longer LA APD90 than sitagliptin-treated WKY, but SHR and sitagliptin-treated SHR had similar LA APD90. Sitagliptin-treated WKY or sitagliptin-treated SHR had larger (RA-LA) APD90 differences than WKY or SHR, respectively. Moreover, as compared to WKY the post-rest potentiation of contraction was decreased in SHR, sitagliptin-treated WKY, and sitagliptin-treated SHR. Conclusions: Sitagliptin significantly affects the electromechanical characteristics of PVs and atria, which can be modulated by hypertension.",
keywords = "Atrial fibrillation, Atrium, Dipeptidyl peptidase inhibitor-4, Hypertension, Pulmonary vein",
author = "Chang, {Chien Jung} and Yang, {Ten Fang} and Lee, {Tin I.} and Chen, {Yao Chang} and Kao, {Yu Hsun} and Chen, {Shih Ann} and Chen, {Yi Jen}",
year = "2014",
language = "English",
volume = "30",
pages = "29--37",
journal = "Acta Cardiologica Sinica",
issn = "1011-6842",
publisher = "Republic of China Society of Cardiology",
number = "1",

}

TY - JOUR

T1 - Sitagliptin modulates the electrical and mechanical characteristics of pulmonary vein and atrium

AU - Chang, Chien Jung

AU - Yang, Ten Fang

AU - Lee, Tin I.

AU - Chen, Yao Chang

AU - Kao, Yu Hsun

AU - Chen, Shih Ann

AU - Chen, Yi Jen

PY - 2014

Y1 - 2014

N2 - Background: The pulmonary veins (PVs) and atria are important foci during that period when atrial fibrillation (AF) is generated and maintained. It is well understood that hypertension and diabetesmellitus (DM) are important risk factors for AF. Dipeptidyl peptidase-IV (DPP-4) inhibitors are newagents in the fight against type 2 DM, though they have been found to have several cardiovascular effects. However, it is not clear whether DPP-4 may modulate the electrical and mechanical characteristics in hypertensive atrium or PVs. Methods: Conventional microelectrodes were used to record the action potentials (APs) in isolated PVs, right atrium (RA), and left atrium (LA) in Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) with or without sitagliptin (10 mg/kg) for 4 weeks. Results: WKY ( n = 5), SHR ( n = 7), sitagliptin-treated WKY ( n = 5) and sitagliptin-treated SHR ( n = 7) had similar PV or sinoatrial spontaneous beating rates. However, the sitagliptin-treated WKY had fewer sinoatrial-PV beating rate differences than WKY, SHR or sitagliptin-treated SHR. WKY and SHR had shorter 90% (APD 90) of RA AP duration than sitagliptin-treated WKY or sitagliptin-treated SHR. In contrast, WKY had longer LA APD90 than sitagliptin-treated WKY, but SHR and sitagliptin-treated SHR had similar LA APD90. Sitagliptin-treated WKY or sitagliptin-treated SHR had larger (RA-LA) APD90 differences than WKY or SHR, respectively. Moreover, as compared to WKY the post-rest potentiation of contraction was decreased in SHR, sitagliptin-treated WKY, and sitagliptin-treated SHR. Conclusions: Sitagliptin significantly affects the electromechanical characteristics of PVs and atria, which can be modulated by hypertension.

AB - Background: The pulmonary veins (PVs) and atria are important foci during that period when atrial fibrillation (AF) is generated and maintained. It is well understood that hypertension and diabetesmellitus (DM) are important risk factors for AF. Dipeptidyl peptidase-IV (DPP-4) inhibitors are newagents in the fight against type 2 DM, though they have been found to have several cardiovascular effects. However, it is not clear whether DPP-4 may modulate the electrical and mechanical characteristics in hypertensive atrium or PVs. Methods: Conventional microelectrodes were used to record the action potentials (APs) in isolated PVs, right atrium (RA), and left atrium (LA) in Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) with or without sitagliptin (10 mg/kg) for 4 weeks. Results: WKY ( n = 5), SHR ( n = 7), sitagliptin-treated WKY ( n = 5) and sitagliptin-treated SHR ( n = 7) had similar PV or sinoatrial spontaneous beating rates. However, the sitagliptin-treated WKY had fewer sinoatrial-PV beating rate differences than WKY, SHR or sitagliptin-treated SHR. WKY and SHR had shorter 90% (APD 90) of RA AP duration than sitagliptin-treated WKY or sitagliptin-treated SHR. In contrast, WKY had longer LA APD90 than sitagliptin-treated WKY, but SHR and sitagliptin-treated SHR had similar LA APD90. Sitagliptin-treated WKY or sitagliptin-treated SHR had larger (RA-LA) APD90 differences than WKY or SHR, respectively. Moreover, as compared to WKY the post-rest potentiation of contraction was decreased in SHR, sitagliptin-treated WKY, and sitagliptin-treated SHR. Conclusions: Sitagliptin significantly affects the electromechanical characteristics of PVs and atria, which can be modulated by hypertension.

KW - Atrial fibrillation

KW - Atrium

KW - Dipeptidyl peptidase inhibitor-4

KW - Hypertension

KW - Pulmonary vein

UR - http://www.scopus.com/inward/record.url?scp=84898467363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898467363&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84898467363

VL - 30

SP - 29

EP - 37

JO - Acta Cardiologica Sinica

JF - Acta Cardiologica Sinica

SN - 1011-6842

IS - 1

ER -