Single dose pharmacokinetic study of lithium in Taiwanese/Chinese bipolar patients

Ching Fa Lee, Yong Yi Yang, Oliver Yoa Pu Hu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: The purpose of this study is to investigate the single dose pharmacokinetics of lithium in Taiwanese/Chinese bipolar patients for future interracial comparisons. Method: Eight bipolar patients took 900 mg of lithium carbonate after overnight fasting. Blood samples of 5 mL were taken after 15 min: 30 min, 45 min, 1 h, 2 h, 3 h, 4 h, 7 h, 9 h, 15 h, 25 h and 31 h after dosing. The computer programs CSTRIP and PCNONLIN were used for pharmacokinetic analysis. Results: The pharmacokinetic parameters obtained were as follows: C (max), 0.970 ± 0.170 (SD) mmol/L; T(max) 1.59 ± 0.78 h; AUC(31h) = 548.9 ± 135.4 mmol.m/L; AUC(∞) = 722.6 ± 262.7 mmol.m/L; β-half-life = 16.3 ± 7.18 h; K-half-life = 0.613 ± 0.442 h; Cl(oral) = 1.13 ± 0.39 mL/min/kg; Vd/F = 1.43 ± 0.387 L/kg. Most of the pharmacokinetic parameters were within the ranges reported in investigations of Caucasian subjects. Conclusions: This study showed that racial differences in lithium pharmacokinetics might not exist. We suggest that methodological designs, including method of blood sampling, measurement of lithium, and pharmacokinetic and statistical calculations, be standardised if future cross-ethnic comparisons are to be conducted.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalAustralian and New Zealand Journal of Psychiatry
Volume32
Issue number1
DOIs
Publication statusPublished - Feb 1 1998
Externally publishedYes

Keywords

  • Bipolar patients
  • Lithium
  • Pharmacokinetics

ASJC Scopus subject areas

  • Psychiatry and Mental health

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