Single-center experience: Immunosuppressive therapy as frontline treatment for 33 children with acquired severe aplastic anemia

I. Anne Huang, Tang H. Jaing, Chao Ping Yang, Iou J. Hung, Pei Kwei Tsay, Chih Cheng Luo, Chien Feng Sun

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7 Citations (Scopus)

Abstract

The authors retrospectively analyzed the records of 33 children with acquired severe aplastic anemia (SAA) diagnosed from July 1998 to October 2007 and first treated by immunosuppressive therapy (IST). Serial hematologic parameters, complications, transfusion requirements, and time to response were assessed. Allogeneic hematopoietic stem cell transplantation (HSCT) was attempted in 7 patients after failure of IST (n = 6) or relapse following an initial response to IST (n = 1). One child died of post-transplant lymphoproliferative disorder. Thirty of the 33 patients are alive and well after a median follow-up of 45 months (range, 7-116 months). Overall (transfusion-independent) response to IST was 73% (24/33). The actuarial 5 years survival rate was 89.4%. In this study, all patients with SAA received IST as standard front-line therapy. Approximately three-fourths of patients with SAA have durable recovery and excellent overall survival.

Original languageEnglish
Pages (from-to)487-495
Number of pages9
JournalPediatric Hematology and Oncology
Volume26
Issue number7
DOIs
Publication statusPublished - 2009
Externally publishedYes

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Keywords

  • Frontline therapy
  • Hematopoietic stem cell ransplantation
  • Immunosuppressive therapy
  • Severe aplastic anemia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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