Simultaneous detection of DNA bases on electrodes chemically modified with graphene-new fuchsin

Jia Yi Chen, Shen Ming Chen, Wen Hui Weng, Ying Li, Shauh Der Yeh

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The graphene combined with New Fuchsin (NF) to prepare graphene-NF modified electrode. Graphene obtained high mechanical strength, non-antigenic biopolymer and low toxicity toward mammalian cells. Electrochemical impedance spectroscopy (EIS) applied diffusion coefficient values and some information about the kinetics of electron transfer during the redox reactions. Surface morphology of the modified electrode using scanning electron microscopy (SEM) which revealed that graphene and NF were coated on electrode. Differential pulse voltammetry (DPVs) was used for the determination of analytes. DPVs not only increased the electrocatalytic current linear concentration range, also lowered the overpotential to oxidation the interferences in the measurements. The Graphene exhibited a promising enhanced electrocatalytic activity towards analytes and enhances the loaded and stability. In this paper, the electrochemical oxidation of Cytosine (C), Thymine (T), Guanine (G) and Adenine (A) at same time.

Original languageEnglish
Pages (from-to)3963-3973
Number of pages11
JournalInternational Journal of Electrochemical Science
Volume8
Issue number3
Publication statusPublished - Mar 2013

Keywords

  • Adenine (A)
  • Cytosine (C)
  • Graphene and new fuchsin (NF)
  • Guanine (G)
  • Thymine (T)

ASJC Scopus subject areas

  • Electrochemistry

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