Silent brain infarctions and leuko-araiosis in Chinese patients with first-ever acute lacunar strokes

Peterus Thajeb, Wen Yuan Lee, Chung-Hung Shih, Teguh Thajeb, James Davis, Rosanne Harrigan, chang linda

Research output: Contribution to journalArticle

Abstract

We report on silent brain infarction (SBI) and leuko- araiosis (LA) of 23 patients with clinically diagnosed “first-ever” acute ischemic lacunar stroke. The lacunar syndromes were pure motor hemiparesis (10), pure sensory syndrome (2), ataxic hemiparesis (3), dysarthria clumsy hand syndrome (3), and sensory- motor deficit (5). Nineteen out of the 23 patients presented with completed strokes on arrival to the hospital, and 4 (17%) developed evolving-stroke within 24 hours of stroke onset. A lacune corresponded to the acute stroke could be found in all patients on brain magnetic resonance imaging (MRI), and in 18 (78%) on brain computed tomography (CT). MRI showed additional subclinical or asymptomatic “silent brain infarctions or lacunes” (SBI) in 19 (83%) of 23 patients, and leuko-araiosis (LA) of moderate to severe degree (> grade 2) was present in 61% of patients although dementia was absent. Hypertension is the risk factor in 78% of cases followed by diabetes mellitus, smoking, and elevated plasma cholesterol level. Independence of the types of lacunar syndromes, patients with hypertension and diabetes mellitus are associated with high grade LA. None with normal blood pressure and plasma glucose had grade 3 or grade 4 LA (p < 0.05). In conclusion, evolving-stroke occurs in one- fifth of patients with “first-ever” lacunar infarct within the first 24 hours of stroke onset. SBI was found in 83% of cases. Hypertension and diabetes mellitus are associated with additional SBI and high grade LA. The severity of leuko-araiosis per se dictates the cerebrovascular risks.
Original languageEnglish
Pages (from-to)443-447
Number of pages5
JournalJournal of Biomedical Science and Engineering
Volume3
Issue number5
DOIs
Publication statusPublished - 2010

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Brain Infarction
Lacunar Stroke
Leukoaraiosis
Stroke
Diabetes Mellitus
Paresis
Hypertension
Magnetic Resonance Imaging
Dysarthria
Brain
Hypercholesterolemia
Dementia
Hand
Smoking
Tomography
Blood Pressure
Glucose

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Silent brain infarctions and leuko-araiosis in Chinese patients with first-ever acute lacunar strokes. / Thajeb, Peterus ; Lee, Wen Yuan; Shih, Chung-Hung; Thajeb, Teguh ; Davis, James; Harrigan, Rosanne ; linda , chang.

In: Journal of Biomedical Science and Engineering, Vol. 3, No. 5, 2010, p. 443-447.

Research output: Contribution to journalArticle

Thajeb, Peterus ; Lee, Wen Yuan ; Shih, Chung-Hung ; Thajeb, Teguh ; Davis, James ; Harrigan, Rosanne ; linda , chang. / Silent brain infarctions and leuko-araiosis in Chinese patients with first-ever acute lacunar strokes. In: Journal of Biomedical Science and Engineering. 2010 ; Vol. 3, No. 5. pp. 443-447.
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