Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR

Tsui Chin Huang, Hsin Yi Chang, Cheng Yu Chen, Pei Yi Wu, Hsinyu Lee, Yung Feng Liao, Wen Ming Hsu, Hsuan Cheng Huang, Hsueh Fen Juan

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis. Further miR-124 is predicted to target aryl hydrocarbon receptor (AHR) which may promote neuroblastoma cell differentiation. We validate that miR-124 may suppress the expression of AHR by targeting its 3′-UTR. These results suggest that miR-124 could serve as a potential therapeutic target of neuroblastoma.

Original languageEnglish
Pages (from-to)3582-3586
Number of pages5
JournalFEBS Letters
Volume585
Issue number22
DOIs
Publication statusPublished - Nov 16 2011

Keywords

  • AHR
  • Cell differentiation
  • MicroRNA
  • miR-124
  • Neuroblastoma

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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