Significant synergistic effect of peroxisome proliferator-activated receptor γ C-2821T and diabetes on the risk of ischemic stroke

Fang-I Hsieh, Wei Cheng Lo, Huey-Juan Lin, Yi-Chen Hsieh, Li-Ming Lien, Chyi-Huey Bai, Hung Pin Tseng, Hung-Yi Chiou

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE - To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN AND METHODS - The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARγ were determined by PCR-restriction fragment-length polymorphism. RESULTS - A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors. CONCLUSIONS - The -2821C allele of PPARγ was a strong predictor of ischemic stroke for diabetic patients.

Original languageEnglish
Pages (from-to)2033-2035
Number of pages3
JournalDiabetes Care
Volume32
Issue number11
DOIs
Publication statusPublished - Nov 2009

Fingerprint

Peroxisome Proliferator-Activated Receptors
Stroke
Genetic Polymorphisms
Alleles
Hypertension
Restriction Fragment Length Polymorphisms
Case-Control Studies
Research Design
Odds Ratio
Polymerase Chain Reaction

Keywords

  • diabetes mellitus
  • cardiovascular risk
  • risk assessment

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

Cite this

Significant synergistic effect of peroxisome proliferator-activated receptor γ C-2821T and diabetes on the risk of ischemic stroke. / Hsieh, Fang-I; Lo, Wei Cheng; Lin, Huey-Juan; Hsieh, Yi-Chen; Lien, Li-Ming; Bai, Chyi-Huey; Tseng, Hung Pin; Chiou, Hung-Yi.

In: Diabetes Care, Vol. 32, No. 11, 11.2009, p. 2033-2035.

Research output: Contribution to journalArticle

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AU - Hsieh, Yi-Chen

AU - Lien, Li-Ming

AU - Bai, Chyi-Huey

AU - Tseng, Hung Pin

AU - Chiou, Hung-Yi

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AB - OBJECTIVE - To explore the relationship between the genetic polymorphisms of PPARγ (Pro12Ala, C1431T, and C-2821T) and the risk of ischemic stroke and to investigate whether these genetic polymorphisms of PPARγ would modify the risk of ischemic stroke among patients with hypertension or diabetes. RESEARCH DESIGN AND METHODS - The case-control study was conducted with 537 ischemic stroke patients and 537 control subjects. A structured questionnaire was used to collect information on conventional cardiovascular risk factors and laboratory results. The genetic polymorphisms of PPARγ were determined by PCR-restriction fragment-length polymorphism. RESULTS - A significant interaction was seen between the -2821C allele and diabetes but not between this allele and hypertension. A markedly elevated risk of ischemic stroke (odds ratio 9.7) was found in the subjects with diabetes and the -2821C allele compared with that in those without these two risk factors. CONCLUSIONS - The -2821C allele of PPARγ was a strong predictor of ischemic stroke for diabetic patients.

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