Abstract
Tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) has high affinity for matrix metalloproteinase-2 (MMP-2). Few studies simultaneously investigate their implication in prognosis of patients with cervical cancer. We used reverse transcription-polymerase chain reaction and immunohistochemical method for cervical tissues and microarrays to investigate the association among TIMP-2, MMP-2, clinicopathological parameters, and prognosis of patients with cancer. Our results showed that cancer tissues exhibited less TIMP-2 expression and patients with pelvic lymph node metastasis had less TIMP-2 expression. Positive TIMP-2 constellated with negative MMP-2 indicated lower recurrence probability and better overall survival. The protective effect of TIMP-2 expression may overcome the adverse effect of MMP-2 expression in terms of disease-free interval and overall survival while neither TIMP-2 nor MMP-2 alone can be used to predict outcome. We suggest that following patients other than those with positive TIMP-2 and negative MMP-2 expression more closely and intensely may improve their prognosis.
Original language | English |
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Pages (from-to) | 798-808 |
Number of pages | 11 |
Journal | Reproductive Sciences |
Volume | 18 |
Issue number | 8 |
DOIs | |
Publication status | Published - Aug 2011 |
Externally published | Yes |
Keywords
- cancer of uterine cervix
- inhibitor of matrix metalloproteinase-2
- matrix metalloproteinase -2
- overall survival
- recurrence probability
ASJC Scopus subject areas
- Obstetrics and Gynaecology