Abstract
Tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) has high affinity for matrix metalloproteinase-2 (MMP-2). Few studies simultaneously investigate their implication in prognosis of patients with cervical cancer. We used reverse transcription-polymerase chain reaction and immunohistochemical method for cervical tissues and microarrays to investigate the association among TIMP-2, MMP-2, clinicopathological parameters, and prognosis of patients with cancer. Our results showed that cancer tissues exhibited less TIMP-2 expression and patients with pelvic lymph node metastasis had less TIMP-2 expression. Positive TIMP-2 constellated with negative MMP-2 indicated lower recurrence probability and better overall survival. The protective effect of TIMP-2 expression may overcome the adverse effect of MMP-2 expression in terms of disease-free interval and overall survival while neither TIMP-2 nor MMP-2 alone can be used to predict outcome. We suggest that following patients other than those with positive TIMP-2 and negative MMP-2 expression more closely and intensely may improve their prognosis.
| Original language | English |
|---|---|
| Pages (from-to) | 798-808 |
| Number of pages | 11 |
| Journal | Reproductive Sciences |
| Volume | 18 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2011 |
| Externally published | Yes |
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Keywords
- cancer of uterine cervix
- inhibitor of matrix metalloproteinase-2
- matrix metalloproteinase -2
- overall survival
- recurrence probability
ASJC Scopus subject areas
- Obstetrics and Gynaecology
Cite this
Significant relation of tissue inhibitor of matrix metalloproteinase-2 and its combination with matrix metalloproteinase-2 to survival of patients with cancer of uterine cervix. / Wang, Po Hui; Ko, Jiunn Liang; Yang, Shun Fa; Tsai, Hsiu Ting; Tee, Yi Torng; Han, Chih Ping; Lin, Long Yau; Chen, Shiuan Chih; Shih, Yang Tse.
In: Reproductive Sciences, Vol. 18, No. 8, 08.2011, p. 798-808.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Significant relation of tissue inhibitor of matrix metalloproteinase-2 and its combination with matrix metalloproteinase-2 to survival of patients with cancer of uterine cervix
AU - Wang, Po Hui
AU - Ko, Jiunn Liang
AU - Yang, Shun Fa
AU - Tsai, Hsiu Ting
AU - Tee, Yi Torng
AU - Han, Chih Ping
AU - Lin, Long Yau
AU - Chen, Shiuan Chih
AU - Shih, Yang Tse
PY - 2011/8
Y1 - 2011/8
N2 - Tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) has high affinity for matrix metalloproteinase-2 (MMP-2). Few studies simultaneously investigate their implication in prognosis of patients with cervical cancer. We used reverse transcription-polymerase chain reaction and immunohistochemical method for cervical tissues and microarrays to investigate the association among TIMP-2, MMP-2, clinicopathological parameters, and prognosis of patients with cancer. Our results showed that cancer tissues exhibited less TIMP-2 expression and patients with pelvic lymph node metastasis had less TIMP-2 expression. Positive TIMP-2 constellated with negative MMP-2 indicated lower recurrence probability and better overall survival. The protective effect of TIMP-2 expression may overcome the adverse effect of MMP-2 expression in terms of disease-free interval and overall survival while neither TIMP-2 nor MMP-2 alone can be used to predict outcome. We suggest that following patients other than those with positive TIMP-2 and negative MMP-2 expression more closely and intensely may improve their prognosis.
AB - Tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) has high affinity for matrix metalloproteinase-2 (MMP-2). Few studies simultaneously investigate their implication in prognosis of patients with cervical cancer. We used reverse transcription-polymerase chain reaction and immunohistochemical method for cervical tissues and microarrays to investigate the association among TIMP-2, MMP-2, clinicopathological parameters, and prognosis of patients with cancer. Our results showed that cancer tissues exhibited less TIMP-2 expression and patients with pelvic lymph node metastasis had less TIMP-2 expression. Positive TIMP-2 constellated with negative MMP-2 indicated lower recurrence probability and better overall survival. The protective effect of TIMP-2 expression may overcome the adverse effect of MMP-2 expression in terms of disease-free interval and overall survival while neither TIMP-2 nor MMP-2 alone can be used to predict outcome. We suggest that following patients other than those with positive TIMP-2 and negative MMP-2 expression more closely and intensely may improve their prognosis.
KW - cancer of uterine cervix
KW - inhibitor of matrix metalloproteinase-2
KW - matrix metalloproteinase -2
KW - overall survival
KW - recurrence probability
UR - http://www.scopus.com/inward/record.url?scp=79961045274&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961045274&partnerID=8YFLogxK
U2 - 10.1177/1933719111398143
DO - 10.1177/1933719111398143
M3 - Article
C2 - 21422052
AN - SCOPUS:79961045274
VL - 18
SP - 798
EP - 808
JO - Reproductive Sciences
JF - Reproductive Sciences
SN - 1933-7191
IS - 8
ER -