Significant relation of tissue inhibitor of matrix metalloproteinase-2 and its combination with matrix metalloproteinase-2 to survival of patients with cancer of uterine cervix

Po Hui Wang, Jiunn Liang Ko, Shun Fa Yang, Hsiu Ting Tsai, Yi Torng Tee, Chih Ping Han, Long Yau Lin, Shiuan Chih Chen, Yang Tse Shih

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3 Citations (Scopus)


Tissue inhibitor of matrix metalloproteinase-2 (TIMP-2) has high affinity for matrix metalloproteinase-2 (MMP-2). Few studies simultaneously investigate their implication in prognosis of patients with cervical cancer. We used reverse transcription-polymerase chain reaction and immunohistochemical method for cervical tissues and microarrays to investigate the association among TIMP-2, MMP-2, clinicopathological parameters, and prognosis of patients with cancer. Our results showed that cancer tissues exhibited less TIMP-2 expression and patients with pelvic lymph node metastasis had less TIMP-2 expression. Positive TIMP-2 constellated with negative MMP-2 indicated lower recurrence probability and better overall survival. The protective effect of TIMP-2 expression may overcome the adverse effect of MMP-2 expression in terms of disease-free interval and overall survival while neither TIMP-2 nor MMP-2 alone can be used to predict outcome. We suggest that following patients other than those with positive TIMP-2 and negative MMP-2 expression more closely and intensely may improve their prognosis.

Original languageEnglish
Pages (from-to)798-808
Number of pages11
JournalReproductive Sciences
Issue number8
Publication statusPublished - Aug 2011
Externally publishedYes



  • cancer of uterine cervix
  • inhibitor of matrix metalloproteinase-2
  • matrix metalloproteinase -2
  • overall survival
  • recurrence probability

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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