Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease

Kuo Shuen Chen, Po Hui Wang, Shun Fa Yang, Ding Bang Lin, Yi Jiun Lin, Dong Yih Kuo, Long Yau Lin, Ming Tsang Wu, Chiao Wen Lin, Sheuan Lee, Ming Chih Chou, Hsiu Ting Tsai, Yih Shou Hsieh

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13 Citations (Scopus)

Abstract

Background: We investigated the expressions and ratios of type 1 T helper cell (Th1) cytokines interferon-γ (IFN-γ) and interleukin-2 (IL-2), as well as type 2 T helper cell (Th2) cytokines interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-13 (IL-13) and interleukin-10 (IL-10) in pelvic inflammatory disease (PID) patients. Methods: The human cytokine LINCOplex multiplex bead array was used to measure the plasma levels of Th1 and Th2 cytokines in 50 healthy controls, as well as in 41 PID patients before and after routine protocol treatment. Results: Significantly increased expressions of Th1 cytokine IFN-γ (p=0.004), as well as Th2 cytokine IL-5 (p=0.001), and dramatically increased IL-10 (p=0.0001), but significantly decreased expression of Th1 cytokine IL-2 (p=0.029) in PID patients were found after comparison to the control group. The ratio of IFN-γ to IL-13 showed a significant increase, but the ratios of IFN-γ to IL-10 and IL-2 to IL-10 was significantly decreased in PID patients before treatment compared to after treatment and controls. Conclusions: The results indicate that the imbalance and cross-regulation between Th1 and Th2 cytokines pathways is probably contributed to the mechanism of PID.

Original languageEnglish
Pages (from-to)1609-1616
Number of pages8
JournalClinical Chemistry and Laboratory Medicine
Volume46
Issue number11
DOIs
Publication statusPublished - Nov 1 2008
Externally publishedYes

Keywords

  • Interferon-γ
  • Interleukin-10
  • Pelvic inflammatory disease

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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  • Cite this

    Chen, K. S., Wang, P. H., Yang, S. F., Lin, D. B., Lin, Y. J., Kuo, D. Y., Lin, L. Y., Wu, M. T., Lin, C. W., Lee, S., Chou, M. C., Tsai, H. T., & Hsieh, Y. S. (2008). Significant elevation of a Th2 cytokine, interleukin-10, in pelvic inflammatory disease. Clinical Chemistry and Laboratory Medicine, 46(11), 1609-1616. https://doi.org/10.1515/CCLM.2008.318