Significant elevation and correlation of plasma neutrophil gelatinase associated lipocalin and its complex with matrix metalloproteinase-9 in patients with pelvic inflammatory disease

Hsiu Ting Tsai, Pen Hua Su, Tsung Hsien Lee, Yi Torng Tee, Long Yau Lin, Shun Fa Yang, Po Hui Wang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Backgrounds: To detect the expression of plasma neutrophil gelatinase associated lipocalin (NGAL) and its complex with matrix metalloproteinase-9 (MMP-9) in patients with pelvic inflammatory disease (PID). Methods: Enzyme-linked immunosorbent assay was used to measure the levels of plasma NGAL and NGAL/MMP-9 complex. Results: The levels of plasma NGAL or NGAL/MMP-9 complex were increased in patients with PID compared with those in normal controls and decreased significantly after treatment. Pre-treatment plasma level of NGAL was significantly correlated with WBC and neutrophil counts. In patients with PID, plasma level of NGAL/MMP-9 complex was correlated with plasma level of NGAL or MMP-9 significantly. In predicting PID, the sensitivities of NGAL and NGAL/MMP-9 complex were 76.6% and 78.1%; the negative predictive values, 72.7% and 74.5%. Conclusions: Plasma NGAL and NGAL/MMP-9 complex may act as diagnostic adjuvant biomarkers for PID. In patients with PID, about 80% have plasma levels of NGAL or NGAL/MMP-9 complex level > 10.04. ng/ml or 2.33. ng/ml, respectively.

Original languageEnglish
Pages (from-to)1252-1256
Number of pages5
JournalClinica Chimica Acta
Volume412
Issue number13-14
DOIs
Publication statusPublished - Jun 11 2011
Externally publishedYes

Keywords

  • Neutrophil gelatinase associated lipocalin
  • Neutrophil gelatinase associated lipocalin/matrix metalloproteinase-9 complex
  • Pelvic inflammatory disease

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

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