Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 with Atrial Fibrillation in a Taiwanese Population

Shu Hsuan Chang, Juey Jen Hwang, Fu Tien Chiang, Chuen Den Tseng, Ling Ping Lai, Jiunn-Lee Lin, Cho Kai Wu, Chia Ti Tsai

Research output: Contribution to journalArticle

Abstract

Background: A recent genome-wide association study in individuais of European ancestry demonstrated a significant association of the single nucleotide polymorphism (SNP) rs13376333 in KCNN3 on chromosome 1q21 with lone AF, indicating a common genetic basis for AF. Objectives We sought to replicate the association between SNP rs13376333 in KCNN3 and AF in the Taiwanese population. Methods: We conducted a case-control association study and genotyped SNP rs13376333 in 214 lone AF patients (58.3±11.4 years) versus 214 controls (57.7± 13.2 years), and 322 structural AF patients (69.6 ±13.7 years) versus 322 controls (68.4 ±14.2 years). Results: The associations between SNP rs13376333 and structural or lone AF were significant. In lone AF group, the frequency of the minor allele of SNP rs13376333 was 8.6% compared with 3.0% in controls (allelic p<0.001; odds ratio=3.02 [1.546.29]). The frequency of the minor allele of SNP rs13376333 was 6.5% in structural AF patients compared with 3.1% in controls (allelic p=0.004; odds ratio=2.18 [1.23-3.96]). Conclusions: Our results demonstrate that there are significant associations between SNP rs13376333 and the risk of developing both lone and structural AF in the Taiwanese population. The minor allele frequency of SNP rs13376333 was much lower in the Taiwanese population compared to that of the Caucasian populations.

Original languageEnglish
Number of pages1
JournalJournal of Arrhythmia
Volume27
Issue number4
DOIs
Publication statusPublished - Jan 1 2011
Externally publishedYes

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Atrial Fibrillation
Single Nucleotide Polymorphism
Chromosomes
Population
Gene Frequency
Odds Ratio
Genome-Wide Association Study
Case-Control Studies

Keywords

  • atrial fibrillation
  • genetics
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 with Atrial Fibrillation in a Taiwanese Population. / Chang, Shu Hsuan; Hwang, Juey Jen; Chiang, Fu Tien; Tseng, Chuen Den; Lai, Ling Ping; Lin, Jiunn-Lee; Wu, Cho Kai; Tsai, Chia Ti.

In: Journal of Arrhythmia, Vol. 27, No. 4, 01.01.2011.

Research output: Contribution to journalArticle

Chang, Shu Hsuan ; Hwang, Juey Jen ; Chiang, Fu Tien ; Tseng, Chuen Den ; Lai, Ling Ping ; Lin, Jiunn-Lee ; Wu, Cho Kai ; Tsai, Chia Ti. / Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 with Atrial Fibrillation in a Taiwanese Population. In: Journal of Arrhythmia. 2011 ; Vol. 27, No. 4.
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abstract = "Background: A recent genome-wide association study in individuais of European ancestry demonstrated a significant association of the single nucleotide polymorphism (SNP) rs13376333 in KCNN3 on chromosome 1q21 with lone AF, indicating a common genetic basis for AF. Objectives We sought to replicate the association between SNP rs13376333 in KCNN3 and AF in the Taiwanese population. Methods: We conducted a case-control association study and genotyped SNP rs13376333 in 214 lone AF patients (58.3±11.4 years) versus 214 controls (57.7± 13.2 years), and 322 structural AF patients (69.6 ±13.7 years) versus 322 controls (68.4 ±14.2 years). Results: The associations between SNP rs13376333 and structural or lone AF were significant. In lone AF group, the frequency of the minor allele of SNP rs13376333 was 8.6{\%} compared with 3.0{\%} in controls (allelic p<0.001; odds ratio=3.02 [1.546.29]). The frequency of the minor allele of SNP rs13376333 was 6.5{\%} in structural AF patients compared with 3.1{\%} in controls (allelic p=0.004; odds ratio=2.18 [1.23-3.96]). Conclusions: Our results demonstrate that there are significant associations between SNP rs13376333 and the risk of developing both lone and structural AF in the Taiwanese population. The minor allele frequency of SNP rs13376333 was much lower in the Taiwanese population compared to that of the Caucasian populations.",
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AU - Chang, Shu Hsuan

AU - Hwang, Juey Jen

AU - Chiang, Fu Tien

AU - Tseng, Chuen Den

AU - Lai, Ling Ping

AU - Lin, Jiunn-Lee

AU - Wu, Cho Kai

AU - Tsai, Chia Ti

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N2 - Background: A recent genome-wide association study in individuais of European ancestry demonstrated a significant association of the single nucleotide polymorphism (SNP) rs13376333 in KCNN3 on chromosome 1q21 with lone AF, indicating a common genetic basis for AF. Objectives We sought to replicate the association between SNP rs13376333 in KCNN3 and AF in the Taiwanese population. Methods: We conducted a case-control association study and genotyped SNP rs13376333 in 214 lone AF patients (58.3±11.4 years) versus 214 controls (57.7± 13.2 years), and 322 structural AF patients (69.6 ±13.7 years) versus 322 controls (68.4 ±14.2 years). Results: The associations between SNP rs13376333 and structural or lone AF were significant. In lone AF group, the frequency of the minor allele of SNP rs13376333 was 8.6% compared with 3.0% in controls (allelic p<0.001; odds ratio=3.02 [1.546.29]). The frequency of the minor allele of SNP rs13376333 was 6.5% in structural AF patients compared with 3.1% in controls (allelic p=0.004; odds ratio=2.18 [1.23-3.96]). Conclusions: Our results demonstrate that there are significant associations between SNP rs13376333 and the risk of developing both lone and structural AF in the Taiwanese population. The minor allele frequency of SNP rs13376333 was much lower in the Taiwanese population compared to that of the Caucasian populations.

AB - Background: A recent genome-wide association study in individuais of European ancestry demonstrated a significant association of the single nucleotide polymorphism (SNP) rs13376333 in KCNN3 on chromosome 1q21 with lone AF, indicating a common genetic basis for AF. Objectives We sought to replicate the association between SNP rs13376333 in KCNN3 and AF in the Taiwanese population. Methods: We conducted a case-control association study and genotyped SNP rs13376333 in 214 lone AF patients (58.3±11.4 years) versus 214 controls (57.7± 13.2 years), and 322 structural AF patients (69.6 ±13.7 years) versus 322 controls (68.4 ±14.2 years). Results: The associations between SNP rs13376333 and structural or lone AF were significant. In lone AF group, the frequency of the minor allele of SNP rs13376333 was 8.6% compared with 3.0% in controls (allelic p<0.001; odds ratio=3.02 [1.546.29]). The frequency of the minor allele of SNP rs13376333 was 6.5% in structural AF patients compared with 3.1% in controls (allelic p=0.004; odds ratio=2.18 [1.23-3.96]). Conclusions: Our results demonstrate that there are significant associations between SNP rs13376333 and the risk of developing both lone and structural AF in the Taiwanese population. The minor allele frequency of SNP rs13376333 was much lower in the Taiwanese population compared to that of the Caucasian populations.

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