Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B 12 and high homocysteine level with oral lichen planus

Hsin Ming Chen, Yi Ping Wang, Julia Yu Fong Chang, Yang Che Wu, Shih Jung Cheng, Andy Sun

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Background/purpose: A portion of patients with oral lichen planus (OLP) may have nutritional deficiency. This study evaluated whether there was an intimate association of the deficiencies of hemoglobin (Hb), iron, vitamin B 12 , and folic acid and high blood homocysteine level with OLP. Methods: The blood Hb, iron, vitamin B 12 , folic acid, and homocysteine concentrations in 352 OLP patients were measured and compared with the corresponding levels in 352 age- and sex-matched healthy control participants. Results: We found that 77 (21.9%) OLP patients, 48 (13.6%) OLP patients, 25 (7.1%) OLP patients, and one (0.3%) OLP patient had deficiencies of Hb (men < 13g/dL, women < 12g/dL), iron (< 60μg/dL), vitamin B 12 (< 200pg/mL), and folic acid (< 4ng/mL), respectively. Moreover, 52 (14.8%) OLP patients had abnormally high blood homocysteine level. OLP patients had a significantly higher frequency of Hb, iron, or vitamin B 12 deficiency and of abnormally elevated blood homocysteine level than healthy control participants (all p<0.001). Upon further dividing OLP patients into those with major erosive OLP (MjEOLP; n=67), minor erosive OLP (n=202), and nonerosive OLP (NEOLP; n=83), we found that MjEOLP patients had a significantly higher mean homocysteine level than NEOLP patients (p=0.035). Conclusion: We conclude that there is a significant association of deficiencies of Hb, iron, folic acid, and vitamin B 12 and abnormally high blood homocysteine level with OLP. There may be a close relation of high blood homocysteine level to severity of OLP.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalJournal of the Formosan Medical Association
Volume114
Issue number2
DOIs
Publication statusPublished - Feb 1 2015
Externally publishedYes

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Oral Lichen Planus
Homocysteine
Vitamin B 12
Folic Acid
Hemoglobins
Iron
Healthy Volunteers
Vitamin B 12 Deficiency

Keywords

  • Hemoglobin
  • Homocysteine
  • Iron
  • Oral lichen planus
  • Vitamin B

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B 12 and high homocysteine level with oral lichen planus. / Chen, Hsin Ming; Wang, Yi Ping; Chang, Julia Yu Fong; Wu, Yang Che; Cheng, Shih Jung; Sun, Andy.

In: Journal of the Formosan Medical Association, Vol. 114, No. 2, 01.02.2015, p. 124-129.

Research output: Contribution to journalArticle

Chen, Hsin Ming ; Wang, Yi Ping ; Chang, Julia Yu Fong ; Wu, Yang Che ; Cheng, Shih Jung ; Sun, Andy. / Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B 12 and high homocysteine level with oral lichen planus. In: Journal of the Formosan Medical Association. 2015 ; Vol. 114, No. 2. pp. 124-129.
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abstract = "Background/purpose: A portion of patients with oral lichen planus (OLP) may have nutritional deficiency. This study evaluated whether there was an intimate association of the deficiencies of hemoglobin (Hb), iron, vitamin B 12 , and folic acid and high blood homocysteine level with OLP. Methods: The blood Hb, iron, vitamin B 12 , folic acid, and homocysteine concentrations in 352 OLP patients were measured and compared with the corresponding levels in 352 age- and sex-matched healthy control participants. Results: We found that 77 (21.9{\%}) OLP patients, 48 (13.6{\%}) OLP patients, 25 (7.1{\%}) OLP patients, and one (0.3{\%}) OLP patient had deficiencies of Hb (men < 13g/dL, women < 12g/dL), iron (< 60μg/dL), vitamin B 12 (< 200pg/mL), and folic acid (< 4ng/mL), respectively. Moreover, 52 (14.8{\%}) OLP patients had abnormally high blood homocysteine level. OLP patients had a significantly higher frequency of Hb, iron, or vitamin B 12 deficiency and of abnormally elevated blood homocysteine level than healthy control participants (all p<0.001). Upon further dividing OLP patients into those with major erosive OLP (MjEOLP; n=67), minor erosive OLP (n=202), and nonerosive OLP (NEOLP; n=83), we found that MjEOLP patients had a significantly higher mean homocysteine level than NEOLP patients (p=0.035). Conclusion: We conclude that there is a significant association of deficiencies of Hb, iron, folic acid, and vitamin B 12 and abnormally high blood homocysteine level with OLP. There may be a close relation of high blood homocysteine level to severity of OLP.",
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T1 - Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B 12 and high homocysteine level with oral lichen planus

AU - Chen, Hsin Ming

AU - Wang, Yi Ping

AU - Chang, Julia Yu Fong

AU - Wu, Yang Che

AU - Cheng, Shih Jung

AU - Sun, Andy

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AB - Background/purpose: A portion of patients with oral lichen planus (OLP) may have nutritional deficiency. This study evaluated whether there was an intimate association of the deficiencies of hemoglobin (Hb), iron, vitamin B 12 , and folic acid and high blood homocysteine level with OLP. Methods: The blood Hb, iron, vitamin B 12 , folic acid, and homocysteine concentrations in 352 OLP patients were measured and compared with the corresponding levels in 352 age- and sex-matched healthy control participants. Results: We found that 77 (21.9%) OLP patients, 48 (13.6%) OLP patients, 25 (7.1%) OLP patients, and one (0.3%) OLP patient had deficiencies of Hb (men < 13g/dL, women < 12g/dL), iron (< 60μg/dL), vitamin B 12 (< 200pg/mL), and folic acid (< 4ng/mL), respectively. Moreover, 52 (14.8%) OLP patients had abnormally high blood homocysteine level. OLP patients had a significantly higher frequency of Hb, iron, or vitamin B 12 deficiency and of abnormally elevated blood homocysteine level than healthy control participants (all p<0.001). Upon further dividing OLP patients into those with major erosive OLP (MjEOLP; n=67), minor erosive OLP (n=202), and nonerosive OLP (NEOLP; n=83), we found that MjEOLP patients had a significantly higher mean homocysteine level than NEOLP patients (p=0.035). Conclusion: We conclude that there is a significant association of deficiencies of Hb, iron, folic acid, and vitamin B 12 and abnormally high blood homocysteine level with OLP. There may be a close relation of high blood homocysteine level to severity of OLP.

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KW - Vitamin B

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