Significance of cardiac troponin I and creatine kinase release after coronary intervention

C. J. Wu, H. L. Liang, K. R. Chiou, G. Y. Mar, C. J. Tseng, S. L. Lin, H. T. Chiang, C. P. Liu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background. Cardiac troponin I is a highly sensitive and specific marker for early detection of myocardial injury. Whether it can be used to monitor myocardial injury after coronary intervention is uncertain. This study was designed to measure the cardiac troponin I and creatine kinase (CK) after coronary intervention and investigate their clinical significance. Methods. We measured cardiac troponin I and CK levels before intervention and 4 hours, 8 hours, 12 hours and 24 hours after apparently successful coronary intervention in 106 eligible patients. Nine patients were excluded due to missing data. We also followed up the clinical outcome to record major cardiac events (MACE). Results. The frequency of cardiac troponin I increase after coronary intervention was higher than that of CK increase (40.2% vs 8.2%). The frequency of cardiac troponin I increase in the stent group was significantly higher than that in the PTCA group (49.2% vs 21.9%, p < 0.001). The frequency of cardiac troponin I increase was also higher than that of CK increase in patients with in-hospital events (58.8% vs 14.7%). Conclusions. Cardiac troponin I is more sensitive than creatine kinase in detecting myocardial injury after coronary intervention. The incidence of cardiac troponin I increase is significantly higher in patients undergoing stenting than in patients treated with balloon angioplasty only. The cardiac troponin I increase is more highly correlated with in-hospital events than is creatine kinase.

Original languageEnglish
Pages (from-to)343-350
Number of pages8
JournalChinese Medical Journal (Taipei)
Volume64
Issue number6
Publication statusPublished - Sep 11 2001
Externally publishedYes

Fingerprint

Troponin I
Creatine Kinase
Wounds and Injuries
Balloon Angioplasty
Stents
Incidence

Keywords

  • Angioplasty
  • Creatine kinase
  • Stents
  • Troponin I

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wu, C. J., Liang, H. L., Chiou, K. R., Mar, G. Y., Tseng, C. J., Lin, S. L., ... Liu, C. P. (2001). Significance of cardiac troponin I and creatine kinase release after coronary intervention. Chinese Medical Journal (Taipei), 64(6), 343-350.

Significance of cardiac troponin I and creatine kinase release after coronary intervention. / Wu, C. J.; Liang, H. L.; Chiou, K. R.; Mar, G. Y.; Tseng, C. J.; Lin, S. L.; Chiang, H. T.; Liu, C. P.

In: Chinese Medical Journal (Taipei), Vol. 64, No. 6, 11.09.2001, p. 343-350.

Research output: Contribution to journalArticle

Wu, CJ, Liang, HL, Chiou, KR, Mar, GY, Tseng, CJ, Lin, SL, Chiang, HT & Liu, CP 2001, 'Significance of cardiac troponin I and creatine kinase release after coronary intervention', Chinese Medical Journal (Taipei), vol. 64, no. 6, pp. 343-350.
Wu, C. J. ; Liang, H. L. ; Chiou, K. R. ; Mar, G. Y. ; Tseng, C. J. ; Lin, S. L. ; Chiang, H. T. ; Liu, C. P. / Significance of cardiac troponin I and creatine kinase release after coronary intervention. In: Chinese Medical Journal (Taipei). 2001 ; Vol. 64, No. 6. pp. 343-350.
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