Signaling pathway and pepsinogen secretion in Helicobacter pylori-infected human gastric adenocarcinoma

Err Cheng Chan, Chien-Tsu Chen, Yuh Ling Lin, Kuei Tian Chen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Although in vitro studies have suggested that Helicobacter pylori not only attaches to cultured cells but also induces signal transduction events in host cells, the underlying mechanism of H. pylori action has yet to be fully investigated. In the present study, a cytotoxin-positive H. pylori was used to infect and examined for its effect on the stimulation of second messengers in human gastric adenocarcinoma (AGS). Results showed that H. pylori increased cytosolic free calcium concentration [Ca2+]i in host cells in a dose-dependent manner. The increase of [Ca2+]i was due to release from the intracellular Ca2+ store as well as entry to the extracellular Ca2+. H. pylori infection on host cells was also found to induce the generations of inositol phosphates, adenosine 3',5'-cyclic monophosphate, and guanosine 3',5'-cyclic monophosphate, and to stimulate the secretion of pepsinogen.

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalInternational Journal of Molecular Medicine
Volume3
Issue number4
Publication statusPublished - 1999

Keywords

  • Calcium
  • Cyclic nucleotide
  • Gastric adenocarcinoma
  • Helicobacter pylori
  • Inositol phosphates
  • Pepsinogen
  • Signal transduction

ASJC Scopus subject areas

  • Genetics

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