Signal transducer and activator of transcription 1 in breast cancer: Analysis with tissue microarray

Shyr Ming Sheen-Chen, Chao Cheng Huang, Rei Ping Tang, Ching Hsiang Yang, Fong Fu Chou, Hock Liew Eng

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Abstract

Background: Constitutively activated signal transducer and activator of transcription (STAT) proteins are found in various types of tumors. However, there is still very limited information about the role of STATs in breast cancer. The power of the tissue microarray analysis (TMA) technique is the capability of performing a series of analyses of thousands of specimens in a parallel fashion with minimal damage to the original blocks. This study was designed to use TMA in determing the STAT1 status in breast cancer tissues. Materials and Methods: Archival tissue specimens from 102 patients with primary invasive breast cancer were selected and STAT1 expression was analyzed using immunohistochemical staining with tissue microarray. The data of primary tumor staging, age, estrogen receptor status, lymph node status, histological grading and TNM staging were also collected. Results: There were 18 patients (17.6%) with 0 expression in STAT1, 29 patients (28.4%) with 1 expression in STAT1, 21 patients (20.6%) with 2 expression in STAT1 and 34 patients (33.4%) with 3 expression in STAT1. There was no significant relationship between STAT1 expression and age (p=0.203), estrogen receptor status (p=0.221), histological grading (p=0.861), primary tumor staging (p=0.918), lymph node status (p=0.53), or TNM staging (p=0.826). There was no survival difference noted among the four groups with different STAT1 expression (p=0.859). Conclusion: Immuno-histochemical staining with tissue microarray analysis was convenient and feasible for the analysis of STAT1 expression status in breast cancer. STAT1 expression did not show significant correlation with the overall survival rate.

Original languageEnglish
Pages (from-to)2481-2486
Number of pages6
JournalAnticancer Research
Volume27
Issue number4 B
Publication statusPublished - Jul 1 2007
Externally publishedYes

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Keywords

  • Breast cancer
  • Signal transducer and activator of transcription
  • STAT1
  • Tissue microarray

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sheen-Chen, S. M., Huang, C. C., Tang, R. P., Yang, C. H., Chou, F. F., & Eng, H. L. (2007). Signal transducer and activator of transcription 1 in breast cancer: Analysis with tissue microarray. Anticancer Research, 27(4 B), 2481-2486.