Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation

Kuo Li Pan, Ya Wen Hsiao, Yenn Jiang Lin, Li Wei Lo, Yu Feng Hu, Fa Po Chung, Yung Nan Tsai, Tze Fan Chao, Jo Nan Liao, Chin Yu Lin, Shih Jie Jhuo, Chung-Hsing Lin, Allamsetty Suresh, Rohit Walia, Abigail Louise D. Te, Shinya Yamada, Yao Ting Chang, Shih Lin Chang, Shih Ann Chen

Research output: Contribution to journalArticle

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Abstract

Background: Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. Methods and Results: A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation. Conclusions: Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.

Original languageEnglish
Pages (from-to)1449-1455
Number of pages7
JournalCirculation Journal
Volume83
Issue number7
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Atrial Remodeling
Telomere
Atrial Fibrillation
Leukocytes
Catheter Ablation
Recurrence
Biomarkers
ROC Curve
Cicatrix
Blood Cells
Healthy Volunteers
Sensitivity and Specificity

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Leukocyte telomere length

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation. / Pan, Kuo Li; Hsiao, Ya Wen; Lin, Yenn Jiang; Lo, Li Wei; Hu, Yu Feng; Chung, Fa Po; Tsai, Yung Nan; Chao, Tze Fan; Liao, Jo Nan; Lin, Chin Yu; Jhuo, Shih Jie; Lin, Chung-Hsing; Suresh, Allamsetty; Walia, Rohit; Te, Abigail Louise D.; Yamada, Shinya; Chang, Yao Ting; Chang, Shih Lin; Chen, Shih Ann.

In: Circulation Journal, Vol. 83, No. 7, 01.01.2019, p. 1449-1455.

Research output: Contribution to journalArticle

Pan, KL, Hsiao, YW, Lin, YJ, Lo, LW, Hu, YF, Chung, FP, Tsai, YN, Chao, TF, Liao, JN, Lin, CY, Jhuo, SJ, Lin, C-H, Suresh, A, Walia, R, Te, ALD, Yamada, S, Chang, YT, Chang, SL & Chen, SA 2019, 'Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation', Circulation Journal, vol. 83, no. 7, pp. 1449-1455. https://doi.org/10.1253/circj.CJ-18-0880
Pan, Kuo Li ; Hsiao, Ya Wen ; Lin, Yenn Jiang ; Lo, Li Wei ; Hu, Yu Feng ; Chung, Fa Po ; Tsai, Yung Nan ; Chao, Tze Fan ; Liao, Jo Nan ; Lin, Chin Yu ; Jhuo, Shih Jie ; Lin, Chung-Hsing ; Suresh, Allamsetty ; Walia, Rohit ; Te, Abigail Louise D. ; Yamada, Shinya ; Chang, Yao Ting ; Chang, Shih Lin ; Chen, Shih Ann. / Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation. In: Circulation Journal. 2019 ; Vol. 83, No. 7. pp. 1449-1455.
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abstract = "Background: Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. Methods and Results: A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation. Conclusions: Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.",
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TY - JOUR

T1 - Shorter leukocyte telomere length is associated with atrial remodeling and predicts recurrence in younger patients with paroxysmal atrial fibrillation after radiofrequency ablation

AU - Pan, Kuo Li

AU - Hsiao, Ya Wen

AU - Lin, Yenn Jiang

AU - Lo, Li Wei

AU - Hu, Yu Feng

AU - Chung, Fa Po

AU - Tsai, Yung Nan

AU - Chao, Tze Fan

AU - Liao, Jo Nan

AU - Lin, Chin Yu

AU - Jhuo, Shih Jie

AU - Lin, Chung-Hsing

AU - Suresh, Allamsetty

AU - Walia, Rohit

AU - Te, Abigail Louise D.

AU - Yamada, Shinya

AU - Chang, Yao Ting

AU - Chang, Shih Lin

AU - Chen, Shih Ann

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. Methods and Results: A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation. Conclusions: Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.

AB - Background: Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. Methods and Results: A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation. Conclusions: Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.

KW - Atrial fibrillation

KW - Catheter ablation

KW - Leukocyte telomere length

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U2 - 10.1253/circj.CJ-18-0880

DO - 10.1253/circj.CJ-18-0880

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C2 - 31118363

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SP - 1449

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JO - Circulation Journal

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