Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients

Chyi Huey Bai, Jiunn Rong Chen, Hou Chang Chiu, Chia Chi Chou, Lee Young Chau, Wen Harn Pan

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction, and peripheral vascular disease. We aimed to examine whether the length of (GT) nrepeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL. Methods. A total of 183 consecutive firstever ischemic stroke inpatients and 164 non-stroke patients were screened for the length of (GT)nrepeats in HO-1 promoter. The long (L) and short (S) genotype are defined as the averaged repeat number >26 and nrepeats in HO-1 gene promoter may have greater susceptibility to develop cerebral ischemic only in the presence of low HDL-C, suggesting the protective effects in HO-1 genotype S in the process of ischemic stroke, particularly in subjects with poor HDL-C status.

Original languageEnglish
Article number12
JournalJournal of Biomedical Science
Volume17
Issue number1
DOIs
Publication statusPublished - 2010

Fingerprint

Heme Oxygenase-1
Dyslipidemias
Polymorphism
Genes
Stroke
Coronary Artery Disease
Genotype
Peripheral Vascular Diseases
Microsatellite Repeats
Inpatients
Myocardial Infarction

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Pharmacology (medical)

Cite this

Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients. / Bai, Chyi Huey; Chen, Jiunn Rong; Chiu, Hou Chang; Chou, Chia Chi; Chau, Lee Young; Pan, Wen Harn.

In: Journal of Biomedical Science, Vol. 17, No. 1, 12, 2010.

Research output: Contribution to journalArticle

Bai, Chyi Huey ; Chen, Jiunn Rong ; Chiu, Hou Chang ; Chou, Chia Chi ; Chau, Lee Young ; Pan, Wen Harn. / Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients. In: Journal of Biomedical Science. 2010 ; Vol. 17, No. 1.
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AU - Bai, Chyi Huey

AU - Chen, Jiunn Rong

AU - Chiu, Hou Chang

AU - Chou, Chia Chi

AU - Chau, Lee Young

AU - Pan, Wen Harn

PY - 2010

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N2 - Background. The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction, and peripheral vascular disease. We aimed to examine whether the length of (GT) nrepeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL. Methods. A total of 183 consecutive firstever ischemic stroke inpatients and 164 non-stroke patients were screened for the length of (GT)nrepeats in HO-1 promoter. The long (L) and short (S) genotype are defined as the averaged repeat number >26 and nrepeats in HO-1 gene promoter may have greater susceptibility to develop cerebral ischemic only in the presence of low HDL-C, suggesting the protective effects in HO-1 genotype S in the process of ischemic stroke, particularly in subjects with poor HDL-C status.

AB - Background. The microsatellite polymorphism of heme oxygenase (HO)-1 gene promoter has been shown to be associated with the susceptibility to ischemic event, including coronary artery disease (CAD), myocardial infarction, and peripheral vascular disease. We aimed to examine whether the length of (GT) nrepeats in HO-1 gene promoter is associated with ischemic stroke in people with CAD risk factors, especially low level of HDL. Methods. A total of 183 consecutive firstever ischemic stroke inpatients and 164 non-stroke patients were screened for the length of (GT)nrepeats in HO-1 promoter. The long (L) and short (S) genotype are defined as the averaged repeat number >26 and nrepeats in HO-1 gene promoter may have greater susceptibility to develop cerebral ischemic only in the presence of low HDL-C, suggesting the protective effects in HO-1 genotype S in the process of ischemic stroke, particularly in subjects with poor HDL-C status.

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