Short-term clinical disease progression in hiv-infected patients receiving combination antiretroviral therapy: results from the TREAT Asia HIV Observational database

Preeyaporn Srasuebkul, Poh Lian Lim, Man Po Lee, Nagalingeswaran Kumarasamy, Jialun Zhou, Thira Sirisanthana, Patrick C.K. Li, Adeeba Kamarulzaman, Shinichi Oka, Praphan Phanuphak, Saphonn Vonthanak, Tuti P. Merati, Yi Ming A. Chen, Somnuek Sungkanuparph, Goa Tau, Fujie Zhang, Christopher K.C. Lee, Rossana Ditangco, Sanjay Pujari, Jun Y. ChoiJeffery Smith, Matthew G. Law'

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Object The aim of our study was to develop, on the basis of simple clinical data, predictive short-term risk equations for AIDS or death in Asian patients infected with human immunodeficiency virus (HIV) who were included in the TREAT Asia HIV Observational Database. Methods. Inclusion criteria were highly active antiretroviral therapy initiation and completion of required laboratory tests. Predictors of short-term AIDS or death were assessed using Poisson regression. Three different models were developed: a clinical model, a CD4 cell count model, and a CD4 cell count and HIV RNA level model. We separated patients into low-risk, high-risk, and very high-risk groups according to the key risk factors identified. Results. In the clinical model, patients with severe anemia or a body mass index (BMI; calculated as the weight in kilograms divided by the square of the height in meters) ≤18 were at very high risk, and patients who were aged <40 years or were male and had mild anemia were at high risk. In the CD4 cell count model, patients with a CD4 cell count <50 cells/μL, severe anemia, or a BMI ≤18 were at very high risk, and patients who had a CD4 cell count of 51-200 celW/μL, were aged <40 years, or were male and had mild anemia were at high risk. In the CD4 cell count and HIV RNA level model, patients with a CD4 cell count <50 cells/μL, a detectable viral load, severe anemia, or a BMI ≤18 were at very high risk, and patients with a CD4 cell count of 51-200 cells/μL and mild anemia were at high risk. The incidence of new AIDS or death in the clinical model was 1.3, 4.9, and 15.6 events per 100 person-years in the low-risk, high-risk, and very high-risk groups, respectively. In the CD4 cell count model the respective incidences were 0.9, 2.7, and 16.02 events per 100 person-years; in the CD4 cell count and HIV RNA level model, the respective incidences were 0.8, 1.8, and 6.2 events per 100 person-years. Conclusions. These models are simple enough for widespread use in busy clinics and should allow clinicians to identify patients who are at high risk of AIDS or death in Asia and the Pacific region and in resource-poor settings.

Original languageEnglish
Pages (from-to)940-950
Number of pages11
JournalClinical Infectious Diseases
Volume48
Issue number7
DOIs
Publication statusPublished - Apr 1 2009
Externally publishedYes

Fingerprint

Disease Progression
CD4 Lymphocyte Count
HIV
Databases
Anemia
Therapeutics
Acquired Immunodeficiency Syndrome
RNA
Incidence
Highly Active Antiretroviral Therapy
Viral Load
Body Mass Index
Weights and Measures

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Short-term clinical disease progression in hiv-infected patients receiving combination antiretroviral therapy : results from the TREAT Asia HIV Observational database. / Srasuebkul, Preeyaporn; Lim, Poh Lian; Lee, Man Po; Kumarasamy, Nagalingeswaran; Zhou, Jialun; Sirisanthana, Thira; Li, Patrick C.K.; Kamarulzaman, Adeeba; Oka, Shinichi; Phanuphak, Praphan; Vonthanak, Saphonn; Merati, Tuti P.; Chen, Yi Ming A.; Sungkanuparph, Somnuek; Tau, Goa; Zhang, Fujie; Lee, Christopher K.C.; Ditangco, Rossana; Pujari, Sanjay; Choi, Jun Y.; Smith, Jeffery; Law', Matthew G.

In: Clinical Infectious Diseases, Vol. 48, No. 7, 01.04.2009, p. 940-950.

Research output: Contribution to journalArticle

Srasuebkul, P, Lim, PL, Lee, MP, Kumarasamy, N, Zhou, J, Sirisanthana, T, Li, PCK, Kamarulzaman, A, Oka, S, Phanuphak, P, Vonthanak, S, Merati, TP, Chen, YMA, Sungkanuparph, S, Tau, G, Zhang, F, Lee, CKC, Ditangco, R, Pujari, S, Choi, JY, Smith, J & Law', MG 2009, 'Short-term clinical disease progression in hiv-infected patients receiving combination antiretroviral therapy: results from the TREAT Asia HIV Observational database', Clinical Infectious Diseases, vol. 48, no. 7, pp. 940-950. https://doi.org/10.1086/597354
Srasuebkul, Preeyaporn ; Lim, Poh Lian ; Lee, Man Po ; Kumarasamy, Nagalingeswaran ; Zhou, Jialun ; Sirisanthana, Thira ; Li, Patrick C.K. ; Kamarulzaman, Adeeba ; Oka, Shinichi ; Phanuphak, Praphan ; Vonthanak, Saphonn ; Merati, Tuti P. ; Chen, Yi Ming A. ; Sungkanuparph, Somnuek ; Tau, Goa ; Zhang, Fujie ; Lee, Christopher K.C. ; Ditangco, Rossana ; Pujari, Sanjay ; Choi, Jun Y. ; Smith, Jeffery ; Law', Matthew G. / Short-term clinical disease progression in hiv-infected patients receiving combination antiretroviral therapy : results from the TREAT Asia HIV Observational database. In: Clinical Infectious Diseases. 2009 ; Vol. 48, No. 7. pp. 940-950.
@article{30c89eb86569411d8a1f41d309f1dfd7,
title = "Short-term clinical disease progression in hiv-infected patients receiving combination antiretroviral therapy: results from the TREAT Asia HIV Observational database",
abstract = "Object The aim of our study was to develop, on the basis of simple clinical data, predictive short-term risk equations for AIDS or death in Asian patients infected with human immunodeficiency virus (HIV) who were included in the TREAT Asia HIV Observational Database. Methods. Inclusion criteria were highly active antiretroviral therapy initiation and completion of required laboratory tests. Predictors of short-term AIDS or death were assessed using Poisson regression. Three different models were developed: a clinical model, a CD4 cell count model, and a CD4 cell count and HIV RNA level model. We separated patients into low-risk, high-risk, and very high-risk groups according to the key risk factors identified. Results. In the clinical model, patients with severe anemia or a body mass index (BMI; calculated as the weight in kilograms divided by the square of the height in meters) ≤18 were at very high risk, and patients who were aged <40 years or were male and had mild anemia were at high risk. In the CD4 cell count model, patients with a CD4 cell count <50 cells/μL, severe anemia, or a BMI ≤18 were at very high risk, and patients who had a CD4 cell count of 51-200 celW/μL, were aged <40 years, or were male and had mild anemia were at high risk. In the CD4 cell count and HIV RNA level model, patients with a CD4 cell count <50 cells/μL, a detectable viral load, severe anemia, or a BMI ≤18 were at very high risk, and patients with a CD4 cell count of 51-200 cells/μL and mild anemia were at high risk. The incidence of new AIDS or death in the clinical model was 1.3, 4.9, and 15.6 events per 100 person-years in the low-risk, high-risk, and very high-risk groups, respectively. In the CD4 cell count model the respective incidences were 0.9, 2.7, and 16.02 events per 100 person-years; in the CD4 cell count and HIV RNA level model, the respective incidences were 0.8, 1.8, and 6.2 events per 100 person-years. Conclusions. These models are simple enough for widespread use in busy clinics and should allow clinicians to identify patients who are at high risk of AIDS or death in Asia and the Pacific region and in resource-poor settings.",
author = "Preeyaporn Srasuebkul and Lim, {Poh Lian} and Lee, {Man Po} and Nagalingeswaran Kumarasamy and Jialun Zhou and Thira Sirisanthana and Li, {Patrick C.K.} and Adeeba Kamarulzaman and Shinichi Oka and Praphan Phanuphak and Saphonn Vonthanak and Merati, {Tuti P.} and Chen, {Yi Ming A.} and Somnuek Sungkanuparph and Goa Tau and Fujie Zhang and Lee, {Christopher K.C.} and Rossana Ditangco and Sanjay Pujari and Choi, {Jun Y.} and Jeffery Smith and Law', {Matthew G.}",
year = "2009",
month = "4",
day = "1",
doi = "10.1086/597354",
language = "English",
volume = "48",
pages = "940--950",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "7",

}

TY - JOUR

T1 - Short-term clinical disease progression in hiv-infected patients receiving combination antiretroviral therapy

T2 - results from the TREAT Asia HIV Observational database

AU - Srasuebkul, Preeyaporn

AU - Lim, Poh Lian

AU - Lee, Man Po

AU - Kumarasamy, Nagalingeswaran

AU - Zhou, Jialun

AU - Sirisanthana, Thira

AU - Li, Patrick C.K.

AU - Kamarulzaman, Adeeba

AU - Oka, Shinichi

AU - Phanuphak, Praphan

AU - Vonthanak, Saphonn

AU - Merati, Tuti P.

AU - Chen, Yi Ming A.

AU - Sungkanuparph, Somnuek

AU - Tau, Goa

AU - Zhang, Fujie

AU - Lee, Christopher K.C.

AU - Ditangco, Rossana

AU - Pujari, Sanjay

AU - Choi, Jun Y.

AU - Smith, Jeffery

AU - Law', Matthew G.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Object The aim of our study was to develop, on the basis of simple clinical data, predictive short-term risk equations for AIDS or death in Asian patients infected with human immunodeficiency virus (HIV) who were included in the TREAT Asia HIV Observational Database. Methods. Inclusion criteria were highly active antiretroviral therapy initiation and completion of required laboratory tests. Predictors of short-term AIDS or death were assessed using Poisson regression. Three different models were developed: a clinical model, a CD4 cell count model, and a CD4 cell count and HIV RNA level model. We separated patients into low-risk, high-risk, and very high-risk groups according to the key risk factors identified. Results. In the clinical model, patients with severe anemia or a body mass index (BMI; calculated as the weight in kilograms divided by the square of the height in meters) ≤18 were at very high risk, and patients who were aged <40 years or were male and had mild anemia were at high risk. In the CD4 cell count model, patients with a CD4 cell count <50 cells/μL, severe anemia, or a BMI ≤18 were at very high risk, and patients who had a CD4 cell count of 51-200 celW/μL, were aged <40 years, or were male and had mild anemia were at high risk. In the CD4 cell count and HIV RNA level model, patients with a CD4 cell count <50 cells/μL, a detectable viral load, severe anemia, or a BMI ≤18 were at very high risk, and patients with a CD4 cell count of 51-200 cells/μL and mild anemia were at high risk. The incidence of new AIDS or death in the clinical model was 1.3, 4.9, and 15.6 events per 100 person-years in the low-risk, high-risk, and very high-risk groups, respectively. In the CD4 cell count model the respective incidences were 0.9, 2.7, and 16.02 events per 100 person-years; in the CD4 cell count and HIV RNA level model, the respective incidences were 0.8, 1.8, and 6.2 events per 100 person-years. Conclusions. These models are simple enough for widespread use in busy clinics and should allow clinicians to identify patients who are at high risk of AIDS or death in Asia and the Pacific region and in resource-poor settings.

AB - Object The aim of our study was to develop, on the basis of simple clinical data, predictive short-term risk equations for AIDS or death in Asian patients infected with human immunodeficiency virus (HIV) who were included in the TREAT Asia HIV Observational Database. Methods. Inclusion criteria were highly active antiretroviral therapy initiation and completion of required laboratory tests. Predictors of short-term AIDS or death were assessed using Poisson regression. Three different models were developed: a clinical model, a CD4 cell count model, and a CD4 cell count and HIV RNA level model. We separated patients into low-risk, high-risk, and very high-risk groups according to the key risk factors identified. Results. In the clinical model, patients with severe anemia or a body mass index (BMI; calculated as the weight in kilograms divided by the square of the height in meters) ≤18 were at very high risk, and patients who were aged <40 years or were male and had mild anemia were at high risk. In the CD4 cell count model, patients with a CD4 cell count <50 cells/μL, severe anemia, or a BMI ≤18 were at very high risk, and patients who had a CD4 cell count of 51-200 celW/μL, were aged <40 years, or were male and had mild anemia were at high risk. In the CD4 cell count and HIV RNA level model, patients with a CD4 cell count <50 cells/μL, a detectable viral load, severe anemia, or a BMI ≤18 were at very high risk, and patients with a CD4 cell count of 51-200 cells/μL and mild anemia were at high risk. The incidence of new AIDS or death in the clinical model was 1.3, 4.9, and 15.6 events per 100 person-years in the low-risk, high-risk, and very high-risk groups, respectively. In the CD4 cell count model the respective incidences were 0.9, 2.7, and 16.02 events per 100 person-years; in the CD4 cell count and HIV RNA level model, the respective incidences were 0.8, 1.8, and 6.2 events per 100 person-years. Conclusions. These models are simple enough for widespread use in busy clinics and should allow clinicians to identify patients who are at high risk of AIDS or death in Asia and the Pacific region and in resource-poor settings.

UR - http://www.scopus.com/inward/record.url?scp=63649106937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=63649106937&partnerID=8YFLogxK

U2 - 10.1086/597354

DO - 10.1086/597354

M3 - Article

C2 - 19226231

AN - SCOPUS:63649106937

VL - 48

SP - 940

EP - 950

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 7

ER -