Sheng mai san, a Chinese herbal medicine, protects against renal ischaemic injury during heat stroke in the rat

I. Y. Lee, C. C. Lee, C. K. Chang, C. H. Chien, Mao Tsun Lin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

There is evidence that the induction of inducible nitric oxide synthase (iNOS) and peroxynitrite by ischaemia/reperfusion may lead to renal cell injury. Herein, we investigated whether Sheng mai san (SMS), a Chinese herbal medicine, protects against renal ischaemic injury during heat stroke by reducing iNOS-dependent nitric oxide (NO) and peroxynitrite formation. Urethane-anaesthetized rats were exposed to heat stress (ambient temperature 43°C) to induce heat stroke. Control rats were exposed to 24°C. Mean arterial pressure and renal blood flow after the onset of heat stroke were significantly lower in heat stroke rats than in control rats. However, both colonic temperature and renal damage score were greater in heat stroke rats compared with control rats. Similarly, plasma NO, creatinine and blood urea nitrogen (BUN), as well as the renal immunoreactivity of iNOS and peroxynitrite, were significantly higher in heat stroke rats compared with their normothermic controls. Pretreatment with SMS (1.2 g/day per rat for 7 consecutive days before the initiation of heat stress) significantly attenuated the heat stroke-induced arterial hypotension, hyperthermia, renal ischaemia and damage, the increased renal immunoreactivity of iNOS and peroxynitrite and the increased plasma levels of NO, creatinine and BUN. Pretreatment with SMS resulted in a prolongation of survival time in heat stroke. The results of the present study suggest that SMS protects against renal ischaemic damage by reducing iNOS-dependent NO and peroxynitrite production during heat stroke.

Original languageEnglish
Pages (from-to)742-748
Number of pages7
JournalClinical and Experimental Pharmacology and Physiology
Volume32
Issue number9
DOIs
Publication statusPublished - Sep 2005

Keywords

  • Blood urea nitrogen
  • Creatinine
  • Heat stroke
  • Nitric oxide
  • Peroxynitrite
  • Renal ischaemia
  • Sheng mai san

ASJC Scopus subject areas

  • Physiology
  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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