Sharing of human leukocyte antigens in couples with unexplained infertility affects the success of in vitro fertilization and tubal embryo transfer

Hong Nerng Ho, Yu Shih Yang, Rhong Phong Hsieh, Heng Ru Lin, Shee Uan Chen, Hsin Fu Chen, Su Cheng Huang, Tzu Yao Lee, Thomas J. Gill

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

OBJECTIVE: The purpose was to test further our hypothesis that genes, or genetic defects, linked to the major histocompatibility complex affect reproduction by correlating human leukocyte antigen sharing with the success or failure of in vitro fertilization and tubal embryo transfer in couples having unexplained infertility. STUDY DESIGN: Seventy-six couples with unexplained infertility who failed superovulation and intrauterine insemination at least three times were typed for human leukocyte antigens and treated by in vitro fertilization and tubal embryo transfer. The results were correlated with the sharing of human leukocyte antigens in the couples. RESULTS: Thirty-four of the women had successful pregnancies, 36 did not become pregnant, and six became pregnant but aborted shortly thereafter. There was a highly significant excess of human leukocyte antigen sharing in the couples who failed treatment: three of the A, B, DR, and DQ antigens (p = 0.015) or two of the B, DR, and DQ antigens (p = 0.015). No specific human leukocyte antigen alleles were present in excess. CONCLUSIONS: Genes, or genetic defects, linked to the major histocompatibility complex significantly affect the success of in vitro fertilization and tubal embryo transfer just as they affect the prevalence of recurrent spontaneous abortion, cancer, and congenital anomalies. It appears as if the critical genes, or genetic defects, are located in the B-DR-DQ region of the major histocompatibility complex. (AM J OBSTET GYNECOL 1994;170:63-71.)

Original languageEnglish
Pages (from-to)63-71
Number of pages9
JournalAmerican Journal of Obstetrics and Gynecology
Volume170
Issue number1
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

Fingerprint

Embryo Transfer
Fertilization in Vitro
HLA Antigens
Infertility
Major Histocompatibility Complex
Superovulation
Genes
Antigens
Habitual Abortion
Insemination
Spontaneous Abortion
Reproduction
Alleles
Pregnancy
Neoplasms

Keywords

  • in vitro fertilization and tubal embryo transfer
  • major histocompatibility complex-linked genes
  • reproductive immunogenetics
  • Unexplained infertility

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Sharing of human leukocyte antigens in couples with unexplained infertility affects the success of in vitro fertilization and tubal embryo transfer. / Ho, Hong Nerng; Yang, Yu Shih; Hsieh, Rhong Phong; Lin, Heng Ru; Chen, Shee Uan; Chen, Hsin Fu; Huang, Su Cheng; Lee, Tzu Yao; Gill, Thomas J.

In: American Journal of Obstetrics and Gynecology, Vol. 170, No. 1, 01.01.1994, p. 63-71.

Research output: Contribution to journalArticle

Ho, Hong Nerng ; Yang, Yu Shih ; Hsieh, Rhong Phong ; Lin, Heng Ru ; Chen, Shee Uan ; Chen, Hsin Fu ; Huang, Su Cheng ; Lee, Tzu Yao ; Gill, Thomas J. / Sharing of human leukocyte antigens in couples with unexplained infertility affects the success of in vitro fertilization and tubal embryo transfer. In: American Journal of Obstetrics and Gynecology. 1994 ; Vol. 170, No. 1. pp. 63-71.
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AU - Hsieh, Rhong Phong

AU - Lin, Heng Ru

AU - Chen, Shee Uan

AU - Chen, Hsin Fu

AU - Huang, Su Cheng

AU - Lee, Tzu Yao

AU - Gill, Thomas J.

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N2 - OBJECTIVE: The purpose was to test further our hypothesis that genes, or genetic defects, linked to the major histocompatibility complex affect reproduction by correlating human leukocyte antigen sharing with the success or failure of in vitro fertilization and tubal embryo transfer in couples having unexplained infertility. STUDY DESIGN: Seventy-six couples with unexplained infertility who failed superovulation and intrauterine insemination at least three times were typed for human leukocyte antigens and treated by in vitro fertilization and tubal embryo transfer. The results were correlated with the sharing of human leukocyte antigens in the couples. RESULTS: Thirty-four of the women had successful pregnancies, 36 did not become pregnant, and six became pregnant but aborted shortly thereafter. There was a highly significant excess of human leukocyte antigen sharing in the couples who failed treatment: three of the A, B, DR, and DQ antigens (p = 0.015) or two of the B, DR, and DQ antigens (p = 0.015). No specific human leukocyte antigen alleles were present in excess. CONCLUSIONS: Genes, or genetic defects, linked to the major histocompatibility complex significantly affect the success of in vitro fertilization and tubal embryo transfer just as they affect the prevalence of recurrent spontaneous abortion, cancer, and congenital anomalies. It appears as if the critical genes, or genetic defects, are located in the B-DR-DQ region of the major histocompatibility complex. (AM J OBSTET GYNECOL 1994;170:63-71.)

AB - OBJECTIVE: The purpose was to test further our hypothesis that genes, or genetic defects, linked to the major histocompatibility complex affect reproduction by correlating human leukocyte antigen sharing with the success or failure of in vitro fertilization and tubal embryo transfer in couples having unexplained infertility. STUDY DESIGN: Seventy-six couples with unexplained infertility who failed superovulation and intrauterine insemination at least three times were typed for human leukocyte antigens and treated by in vitro fertilization and tubal embryo transfer. The results were correlated with the sharing of human leukocyte antigens in the couples. RESULTS: Thirty-four of the women had successful pregnancies, 36 did not become pregnant, and six became pregnant but aborted shortly thereafter. There was a highly significant excess of human leukocyte antigen sharing in the couples who failed treatment: three of the A, B, DR, and DQ antigens (p = 0.015) or two of the B, DR, and DQ antigens (p = 0.015). No specific human leukocyte antigen alleles were present in excess. CONCLUSIONS: Genes, or genetic defects, linked to the major histocompatibility complex significantly affect the success of in vitro fertilization and tubal embryo transfer just as they affect the prevalence of recurrent spontaneous abortion, cancer, and congenital anomalies. It appears as if the critical genes, or genetic defects, are located in the B-DR-DQ region of the major histocompatibility complex. (AM J OBSTET GYNECOL 1994;170:63-71.)

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