Shape memory effect in 3D-printed scaffolds for self-fitting implants

F. S. Senatov, M. Yu Zadorozhnyy, K. V. Niaza, V. V. Medvedev, S. D. Kaloshkin, N. Yu Anisimova, M. V. Kiselevskiy, Kai Chiang Yang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

3D-printed porous scaffolds based on polylactide (PLA)/15% wt. nano-hydroxyapatite (HA) with shape memory effect (SME) for self-fitting implants were studied. Introduction of HA nanoparticles into the PLA matrix had an effect on the ordering of polymer molecular chains. The presence of HA nanoparticles caused a change in friction between molecular chains during the glass transition. Apparent activation energies of SME for PLA and PLA/HA 3D-printed samples were 490 and 555 kJ/mol, respectively. HA nanoparticles acted as centers for the formation of additional rigid fixed phase that governed shape memory properties. The maximum recovery stress was observed in case of shape programming in the glass transition interval at 64 °C. However, cyclic SME tests showed that the increase in number of cycles “programming – SME activation” led to decrease in shape recovery rate and recovery stresses due to accumulation of defects. It was demonstrated that 3D-printed porous PLA/HA scaffolds support mesenchymal stromal cells (MSCs) survival, and stimulate active proliferation of the cells as well. Such scaffolds with SME colonized by MSCs have the potential to be used as self-fitting implants for bone replacement and could also be beneficial in the engineering of complex tissues. MSCs colonization of scaffold favors vascularization of the implant, which is essential for the successful bone prosthesis.

Original languageEnglish
Pages (from-to)222-231
Number of pages10
JournalEuropean Polymer Journal
Volume93
DOIs
Publication statusPublished - Aug 1 2017

Fingerprint

Shape memory effect
Hydroxyapatite
Scaffolds
Durapatite
Nanoparticles
Recovery
molecular chains
Glass transition
recovery
Bone
programming
nanoparticles
bones
glass
Polymers
Activation energy
Chemical activation
Cells
Tissue
Friction

Keywords

  • 3D-printing
  • Activation energy
  • Polylactide
  • Programming temperature
  • Scaffold
  • Shape memory effect

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Polymers and Plastics
  • Organic Chemistry

Cite this

Senatov, F. S., Zadorozhnyy, M. Y., Niaza, K. V., Medvedev, V. V., Kaloshkin, S. D., Anisimova, N. Y., ... Yang, K. C. (2017). Shape memory effect in 3D-printed scaffolds for self-fitting implants. European Polymer Journal, 93, 222-231. https://doi.org/10.1016/j.eurpolymj.2017.06.011

Shape memory effect in 3D-printed scaffolds for self-fitting implants. / Senatov, F. S.; Zadorozhnyy, M. Yu; Niaza, K. V.; Medvedev, V. V.; Kaloshkin, S. D.; Anisimova, N. Yu; Kiselevskiy, M. V.; Yang, Kai Chiang.

In: European Polymer Journal, Vol. 93, 01.08.2017, p. 222-231.

Research output: Contribution to journalArticle

Senatov, FS, Zadorozhnyy, MY, Niaza, KV, Medvedev, VV, Kaloshkin, SD, Anisimova, NY, Kiselevskiy, MV & Yang, KC 2017, 'Shape memory effect in 3D-printed scaffolds for self-fitting implants', European Polymer Journal, vol. 93, pp. 222-231. https://doi.org/10.1016/j.eurpolymj.2017.06.011
Senatov FS, Zadorozhnyy MY, Niaza KV, Medvedev VV, Kaloshkin SD, Anisimova NY et al. Shape memory effect in 3D-printed scaffolds for self-fitting implants. European Polymer Journal. 2017 Aug 1;93:222-231. https://doi.org/10.1016/j.eurpolymj.2017.06.011
Senatov, F. S. ; Zadorozhnyy, M. Yu ; Niaza, K. V. ; Medvedev, V. V. ; Kaloshkin, S. D. ; Anisimova, N. Yu ; Kiselevskiy, M. V. ; Yang, Kai Chiang. / Shape memory effect in 3D-printed scaffolds for self-fitting implants. In: European Polymer Journal. 2017 ; Vol. 93. pp. 222-231.
@article{5dde3580a3df4fefaff3647331add79a,
title = "Shape memory effect in 3D-printed scaffolds for self-fitting implants",
abstract = "3D-printed porous scaffolds based on polylactide (PLA)/15{\%} wt. nano-hydroxyapatite (HA) with shape memory effect (SME) for self-fitting implants were studied. Introduction of HA nanoparticles into the PLA matrix had an effect on the ordering of polymer molecular chains. The presence of HA nanoparticles caused a change in friction between molecular chains during the glass transition. Apparent activation energies of SME for PLA and PLA/HA 3D-printed samples were 490 and 555 kJ/mol, respectively. HA nanoparticles acted as centers for the formation of additional rigid fixed phase that governed shape memory properties. The maximum recovery stress was observed in case of shape programming in the glass transition interval at 64 °C. However, cyclic SME tests showed that the increase in number of cycles “programming – SME activation” led to decrease in shape recovery rate and recovery stresses due to accumulation of defects. It was demonstrated that 3D-printed porous PLA/HA scaffolds support mesenchymal stromal cells (MSCs) survival, and stimulate active proliferation of the cells as well. Such scaffolds with SME colonized by MSCs have the potential to be used as self-fitting implants for bone replacement and could also be beneficial in the engineering of complex tissues. MSCs colonization of scaffold favors vascularization of the implant, which is essential for the successful bone prosthesis.",
keywords = "3D-printing, Activation energy, Polylactide, Programming temperature, Scaffold, Shape memory effect",
author = "Senatov, {F. S.} and Zadorozhnyy, {M. Yu} and Niaza, {K. V.} and Medvedev, {V. V.} and Kaloshkin, {S. D.} and Anisimova, {N. Yu} and Kiselevskiy, {M. V.} and Yang, {Kai Chiang}",
year = "2017",
month = "8",
day = "1",
doi = "10.1016/j.eurpolymj.2017.06.011",
language = "English",
volume = "93",
pages = "222--231",
journal = "European Polymer Journal",
issn = "0014-3057",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Shape memory effect in 3D-printed scaffolds for self-fitting implants

AU - Senatov, F. S.

AU - Zadorozhnyy, M. Yu

AU - Niaza, K. V.

AU - Medvedev, V. V.

AU - Kaloshkin, S. D.

AU - Anisimova, N. Yu

AU - Kiselevskiy, M. V.

AU - Yang, Kai Chiang

PY - 2017/8/1

Y1 - 2017/8/1

N2 - 3D-printed porous scaffolds based on polylactide (PLA)/15% wt. nano-hydroxyapatite (HA) with shape memory effect (SME) for self-fitting implants were studied. Introduction of HA nanoparticles into the PLA matrix had an effect on the ordering of polymer molecular chains. The presence of HA nanoparticles caused a change in friction between molecular chains during the glass transition. Apparent activation energies of SME for PLA and PLA/HA 3D-printed samples were 490 and 555 kJ/mol, respectively. HA nanoparticles acted as centers for the formation of additional rigid fixed phase that governed shape memory properties. The maximum recovery stress was observed in case of shape programming in the glass transition interval at 64 °C. However, cyclic SME tests showed that the increase in number of cycles “programming – SME activation” led to decrease in shape recovery rate and recovery stresses due to accumulation of defects. It was demonstrated that 3D-printed porous PLA/HA scaffolds support mesenchymal stromal cells (MSCs) survival, and stimulate active proliferation of the cells as well. Such scaffolds with SME colonized by MSCs have the potential to be used as self-fitting implants for bone replacement and could also be beneficial in the engineering of complex tissues. MSCs colonization of scaffold favors vascularization of the implant, which is essential for the successful bone prosthesis.

AB - 3D-printed porous scaffolds based on polylactide (PLA)/15% wt. nano-hydroxyapatite (HA) with shape memory effect (SME) for self-fitting implants were studied. Introduction of HA nanoparticles into the PLA matrix had an effect on the ordering of polymer molecular chains. The presence of HA nanoparticles caused a change in friction between molecular chains during the glass transition. Apparent activation energies of SME for PLA and PLA/HA 3D-printed samples were 490 and 555 kJ/mol, respectively. HA nanoparticles acted as centers for the formation of additional rigid fixed phase that governed shape memory properties. The maximum recovery stress was observed in case of shape programming in the glass transition interval at 64 °C. However, cyclic SME tests showed that the increase in number of cycles “programming – SME activation” led to decrease in shape recovery rate and recovery stresses due to accumulation of defects. It was demonstrated that 3D-printed porous PLA/HA scaffolds support mesenchymal stromal cells (MSCs) survival, and stimulate active proliferation of the cells as well. Such scaffolds with SME colonized by MSCs have the potential to be used as self-fitting implants for bone replacement and could also be beneficial in the engineering of complex tissues. MSCs colonization of scaffold favors vascularization of the implant, which is essential for the successful bone prosthesis.

KW - 3D-printing

KW - Activation energy

KW - Polylactide

KW - Programming temperature

KW - Scaffold

KW - Shape memory effect

UR - http://www.scopus.com/inward/record.url?scp=85020237947&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020237947&partnerID=8YFLogxK

U2 - 10.1016/j.eurpolymj.2017.06.011

DO - 10.1016/j.eurpolymj.2017.06.011

M3 - Article

AN - SCOPUS:85020237947

VL - 93

SP - 222

EP - 231

JO - European Polymer Journal

JF - European Polymer Journal

SN - 0014-3057

ER -