Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice

Ling Ling Hwang, Chien Hua Wang, Tzu Ling Li, Shih Dar Chang, Li Chun Lin, Ching Ping Chen, Chiung Tong Chen, Keng Chen Liang, Ing Kang Ho, Wei Shiung Yang, Lih Chu Chiou

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

Obesity is a potential risk factor for cognitive deficits in the elder humans. Using a high-fat diet (HFD)-induced obese mouse model, we investigated the impacts of HFD on obesity, metabolic and stress hormones, learning performance, and hippocampal synaptic plasticity. Both male and female C57BL/6J mice fed with HFD (3 weeks to 9-12 months) gained significantly more weights than the sex-specific control groups. Compared with the obese female mice, the obese males had similar energy intake but developed more weight gains. The obese male mice developed hyperglycemia, hyperinsulinemia, hypercholesterolemia, and hyperleptinemia, but not hypertriglyceridemia. The obese females had less hyperinsulinemia and hypercholesterolemia than the obese males, and no hyperglycemia and hypertriglyceridemia. In the contextual fear conditioning and step-down passive avoidance tasks, the obese male, but not female, mice showed poorer learning performance than their normal counterparts. These learning deficits were not due to sensorimotor impairment as verified by the open-field and hot-plate tests. Although, basal synaptic transmission characteristics (input-output transfer and paired-pulse facilitation (PPF) ratio) were not significantly different between normal and HFD groups, the magnitudes of synaptic plasticity (long-term potentiation (LTP) and long-term depression (LTD)) were lower at the Schaffer collateral-CA1 synapses of the hippocampal slices isolated from the obese male, but not female, mice, as compared with their sex-specific controls. Our results suggest that male mice are more vulnerable than the females to the impacts of HFD on weight gains, metabolic alterations and deficits of learning, and hippocampal synaptic plasticity.

Original languageEnglish
Pages (from-to)463-469
Number of pages7
JournalObesity
Volume18
Issue number3
DOIs
Publication statusPublished - Mar 2010

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Neuronal Plasticity
High Fat Diet
Sex Characteristics
Obesity
Learning
Obese Mice
Hypertriglyceridemia
Hyperinsulinism
Hypercholesterolemia
Hyperglycemia
Weight Gain
Physiological Stress
Long-Term Potentiation
Energy Intake
Inbred C57BL Mouse
Synaptic Transmission
Synapses
Fear
Hippocampus
Hormones

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. / Hwang, Ling Ling; Wang, Chien Hua; Li, Tzu Ling; Chang, Shih Dar; Lin, Li Chun; Chen, Ching Ping; Chen, Chiung Tong; Liang, Keng Chen; Ho, Ing Kang; Yang, Wei Shiung; Chiou, Lih Chu.

In: Obesity, Vol. 18, No. 3, 03.2010, p. 463-469.

Research output: Contribution to journalArticle

Hwang, LL, Wang, CH, Li, TL, Chang, SD, Lin, LC, Chen, CP, Chen, CT, Liang, KC, Ho, IK, Yang, WS & Chiou, LC 2010, 'Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice', Obesity, vol. 18, no. 3, pp. 463-469. https://doi.org/10.1038/oby.2009.273
Hwang, Ling Ling ; Wang, Chien Hua ; Li, Tzu Ling ; Chang, Shih Dar ; Lin, Li Chun ; Chen, Ching Ping ; Chen, Chiung Tong ; Liang, Keng Chen ; Ho, Ing Kang ; Yang, Wei Shiung ; Chiou, Lih Chu. / Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. In: Obesity. 2010 ; Vol. 18, No. 3. pp. 463-469.
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