Severity of spontaneous echo contrast in the jugular vein associated with ischemic stroke

Hung Yi Hsu, Yu Shan Lee, Ming Che Ou, Chih Ping Chung, Su Yi Chen, Yu Ping Ho, Han Hwa Hu

Research output: Contribution to journalArticle

Abstract

This study evaluated the relationship between spontaneous echo contrast (SEC) in the internal jugular vein (JV), atherosclerotic markers and ischemic stroke. One hundred twenty patients with acute ischemic stroke and 120 controls were recruited. SEC score correlated with plasma level of fibrinogen (coefficient: 0.105, p=0.022), hemoglobin (coefficient: 0.122, p=0.008) and presence of JV reflux (coefficient: 0.314, p<0.001) and peak flow velocity (coefficient: -0.244, p<0.001) in the corresponding JV, but did not correlate with carotid plaque score (coefficient: 0.042, p=0.358) or intima-media thickness (coefficient: 0.067, p=0.303). Multivariate regression analysis revealed that fibrinogen level, SEC score, intima-media thickness, plaque score and history of coronary artery disease were associated with acute ischemic stroke. In conclusion, the severity of SEC in the JV might represent the tendency toward thrombogenesis in diseased cerebral circulation possibly through mechanisms other than arterial atherosclerosis.

Original languageEnglish
Pages (from-to)1427-1433
Number of pages7
JournalUltrasound in Medicine and Biology
Volume40
Issue number7
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

Fingerprint

Jugular Veins
strokes
veins
echoes
Stroke
coefficients
Fibrinogen
fibrinogen
Cerebrovascular Circulation
coronary artery disease
arteriosclerosis
Coronary Artery Disease
Atherosclerosis
Hemoglobins
Multivariate Analysis
Regression Analysis
hemoglobin
markers
regression analysis
tendencies

Keywords

  • Carotid artery
  • Ischemic stroke
  • Jugular vein
  • Spontaneous echo contrast
  • Ultrasonography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

Severity of spontaneous echo contrast in the jugular vein associated with ischemic stroke. / Hsu, Hung Yi; Lee, Yu Shan; Ou, Ming Che; Chung, Chih Ping; Chen, Su Yi; Ho, Yu Ping; Hu, Han Hwa.

In: Ultrasound in Medicine and Biology, Vol. 40, No. 7, 01.01.2014, p. 1427-1433.

Research output: Contribution to journalArticle

Hsu, Hung Yi ; Lee, Yu Shan ; Ou, Ming Che ; Chung, Chih Ping ; Chen, Su Yi ; Ho, Yu Ping ; Hu, Han Hwa. / Severity of spontaneous echo contrast in the jugular vein associated with ischemic stroke. In: Ultrasound in Medicine and Biology. 2014 ; Vol. 40, No. 7. pp. 1427-1433.
@article{6d3b51a95ad047e8af7e75fd5820925e,
title = "Severity of spontaneous echo contrast in the jugular vein associated with ischemic stroke",
abstract = "This study evaluated the relationship between spontaneous echo contrast (SEC) in the internal jugular vein (JV), atherosclerotic markers and ischemic stroke. One hundred twenty patients with acute ischemic stroke and 120 controls were recruited. SEC score correlated with plasma level of fibrinogen (coefficient: 0.105, p=0.022), hemoglobin (coefficient: 0.122, p=0.008) and presence of JV reflux (coefficient: 0.314, p<0.001) and peak flow velocity (coefficient: -0.244, p<0.001) in the corresponding JV, but did not correlate with carotid plaque score (coefficient: 0.042, p=0.358) or intima-media thickness (coefficient: 0.067, p=0.303). Multivariate regression analysis revealed that fibrinogen level, SEC score, intima-media thickness, plaque score and history of coronary artery disease were associated with acute ischemic stroke. In conclusion, the severity of SEC in the JV might represent the tendency toward thrombogenesis in diseased cerebral circulation possibly through mechanisms other than arterial atherosclerosis.",
keywords = "Carotid artery, Ischemic stroke, Jugular vein, Spontaneous echo contrast, Ultrasonography",
author = "Hsu, {Hung Yi} and Lee, {Yu Shan} and Ou, {Ming Che} and Chung, {Chih Ping} and Chen, {Su Yi} and Ho, {Yu Ping} and Hu, {Han Hwa}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.ultrasmedbio.2014.02.016",
language = "English",
volume = "40",
pages = "1427--1433",
journal = "Ultrasound in Medicine and Biology",
issn = "0301-5629",
publisher = "Elsevier USA",
number = "7",

}

TY - JOUR

T1 - Severity of spontaneous echo contrast in the jugular vein associated with ischemic stroke

AU - Hsu, Hung Yi

AU - Lee, Yu Shan

AU - Ou, Ming Che

AU - Chung, Chih Ping

AU - Chen, Su Yi

AU - Ho, Yu Ping

AU - Hu, Han Hwa

PY - 2014/1/1

Y1 - 2014/1/1

N2 - This study evaluated the relationship between spontaneous echo contrast (SEC) in the internal jugular vein (JV), atherosclerotic markers and ischemic stroke. One hundred twenty patients with acute ischemic stroke and 120 controls were recruited. SEC score correlated with plasma level of fibrinogen (coefficient: 0.105, p=0.022), hemoglobin (coefficient: 0.122, p=0.008) and presence of JV reflux (coefficient: 0.314, p<0.001) and peak flow velocity (coefficient: -0.244, p<0.001) in the corresponding JV, but did not correlate with carotid plaque score (coefficient: 0.042, p=0.358) or intima-media thickness (coefficient: 0.067, p=0.303). Multivariate regression analysis revealed that fibrinogen level, SEC score, intima-media thickness, plaque score and history of coronary artery disease were associated with acute ischemic stroke. In conclusion, the severity of SEC in the JV might represent the tendency toward thrombogenesis in diseased cerebral circulation possibly through mechanisms other than arterial atherosclerosis.

AB - This study evaluated the relationship between spontaneous echo contrast (SEC) in the internal jugular vein (JV), atherosclerotic markers and ischemic stroke. One hundred twenty patients with acute ischemic stroke and 120 controls were recruited. SEC score correlated with plasma level of fibrinogen (coefficient: 0.105, p=0.022), hemoglobin (coefficient: 0.122, p=0.008) and presence of JV reflux (coefficient: 0.314, p<0.001) and peak flow velocity (coefficient: -0.244, p<0.001) in the corresponding JV, but did not correlate with carotid plaque score (coefficient: 0.042, p=0.358) or intima-media thickness (coefficient: 0.067, p=0.303). Multivariate regression analysis revealed that fibrinogen level, SEC score, intima-media thickness, plaque score and history of coronary artery disease were associated with acute ischemic stroke. In conclusion, the severity of SEC in the JV might represent the tendency toward thrombogenesis in diseased cerebral circulation possibly through mechanisms other than arterial atherosclerosis.

KW - Carotid artery

KW - Ischemic stroke

KW - Jugular vein

KW - Spontaneous echo contrast

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=84902008562&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902008562&partnerID=8YFLogxK

U2 - 10.1016/j.ultrasmedbio.2014.02.016

DO - 10.1016/j.ultrasmedbio.2014.02.016

M3 - Article

C2 - 24768488

AN - SCOPUS:84902008562

VL - 40

SP - 1427

EP - 1433

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

SN - 0301-5629

IS - 7

ER -