Severe adenovirus infection in children

Yu Yu Chuang, Cheng Hsun Chiu, Kin Sun Wong, Joyce Guei Huang, Yhu Chering Huang, Luan Yin Chang, Tzou Yien Lin

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

During the period from July 1, 1999 to September 30, 2000, 9 children with severe adenovirus infection were treated at Chang Gung Children's Hospital. The mean age was 22 months (range, 5-50 months). All of them had lower respiratory tract infections, which manifested as lobar or segmental pneumonia and pleural effusion. Eight (88.9%) of the 9 patients required intensive care and 4 of them required mechanical ventilation. Abnormal laboratory findings included leukocytosis, elevated C-reactive protein, anemia, and prolonged prothrombin time and partial thromboplastin time. Extrapulmonary complications included hepatitis (6 cases), encephalitis (3), conjunctivitis (3), periorbital ecchymosis (1), and coagulopathy (2). One patient died, resulting in a mortality rate of 12.5%. Follow-up at 3 months postdischarge, 5 patients (62.5% of survivors) had bronchiolitis obliterans and/or organizing pneumonia. Seven patients were infected by serotype 3 adenovirus, 1 patient by serotype 2, and another by serotype 11. In conclusion, the clinical, laboratory, and radiographic features of severe adenovirus infection may mimic bacterial infection. Rapid progression of the clinical course despite antibiotic therapy and the presence of unusual extrapulmonary symptoms are important clinical clues in the diagnosis of severe adenoviral infection.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalJournal of Microbiology, Immunology and Infection
Volume36
Issue number1
Publication statusPublished - Mar 2003
Externally publishedYes

Fingerprint

Adenoviridae Infections
Cryptogenic Organizing Pneumonia
Ecchymosis
Conjunctivitis
Partial Thromboplastin Time
Prothrombin Time
Leukocytosis
Encephalitis
Pleural Effusion
Critical Care
Artificial Respiration
Bacterial Infections
Adenoviridae
Respiratory Tract Infections
C-Reactive Protein
Hepatitis
Survivors
Anemia
Pneumonia
Anti-Bacterial Agents

Keywords

  • Adenovirus
  • Children
  • Lower respiratory tract infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)

Cite this

Chuang, Y. Y., Chiu, C. H., Wong, K. S., Huang, J. G., Huang, Y. C., Chang, L. Y., & Lin, T. Y. (2003). Severe adenovirus infection in children. Journal of Microbiology, Immunology and Infection, 36(1), 37-40.

Severe adenovirus infection in children. / Chuang, Yu Yu; Chiu, Cheng Hsun; Wong, Kin Sun; Huang, Joyce Guei; Huang, Yhu Chering; Chang, Luan Yin; Lin, Tzou Yien.

In: Journal of Microbiology, Immunology and Infection, Vol. 36, No. 1, 03.2003, p. 37-40.

Research output: Contribution to journalArticle

Chuang, YY, Chiu, CH, Wong, KS, Huang, JG, Huang, YC, Chang, LY & Lin, TY 2003, 'Severe adenovirus infection in children', Journal of Microbiology, Immunology and Infection, vol. 36, no. 1, pp. 37-40.
Chuang YY, Chiu CH, Wong KS, Huang JG, Huang YC, Chang LY et al. Severe adenovirus infection in children. Journal of Microbiology, Immunology and Infection. 2003 Mar;36(1):37-40.
Chuang, Yu Yu ; Chiu, Cheng Hsun ; Wong, Kin Sun ; Huang, Joyce Guei ; Huang, Yhu Chering ; Chang, Luan Yin ; Lin, Tzou Yien. / Severe adenovirus infection in children. In: Journal of Microbiology, Immunology and Infection. 2003 ; Vol. 36, No. 1. pp. 37-40.
@article{cafd5c4aea6e482fbbd0e7ace5da9875,
title = "Severe adenovirus infection in children",
abstract = "During the period from July 1, 1999 to September 30, 2000, 9 children with severe adenovirus infection were treated at Chang Gung Children's Hospital. The mean age was 22 months (range, 5-50 months). All of them had lower respiratory tract infections, which manifested as lobar or segmental pneumonia and pleural effusion. Eight (88.9{\%}) of the 9 patients required intensive care and 4 of them required mechanical ventilation. Abnormal laboratory findings included leukocytosis, elevated C-reactive protein, anemia, and prolonged prothrombin time and partial thromboplastin time. Extrapulmonary complications included hepatitis (6 cases), encephalitis (3), conjunctivitis (3), periorbital ecchymosis (1), and coagulopathy (2). One patient died, resulting in a mortality rate of 12.5{\%}. Follow-up at 3 months postdischarge, 5 patients (62.5{\%} of survivors) had bronchiolitis obliterans and/or organizing pneumonia. Seven patients were infected by serotype 3 adenovirus, 1 patient by serotype 2, and another by serotype 11. In conclusion, the clinical, laboratory, and radiographic features of severe adenovirus infection may mimic bacterial infection. Rapid progression of the clinical course despite antibiotic therapy and the presence of unusual extrapulmonary symptoms are important clinical clues in the diagnosis of severe adenoviral infection.",
keywords = "Adenovirus, Children, Lower respiratory tract infection",
author = "Chuang, {Yu Yu} and Chiu, {Cheng Hsun} and Wong, {Kin Sun} and Huang, {Joyce Guei} and Huang, {Yhu Chering} and Chang, {Luan Yin} and Lin, {Tzou Yien}",
year = "2003",
month = "3",
language = "English",
volume = "36",
pages = "37--40",
journal = "Journal of Microbiology, Immunology and Infection",
issn = "0253-2662",
publisher = "Elsevier Taiwan LLC",
number = "1",

}

TY - JOUR

T1 - Severe adenovirus infection in children

AU - Chuang, Yu Yu

AU - Chiu, Cheng Hsun

AU - Wong, Kin Sun

AU - Huang, Joyce Guei

AU - Huang, Yhu Chering

AU - Chang, Luan Yin

AU - Lin, Tzou Yien

PY - 2003/3

Y1 - 2003/3

N2 - During the period from July 1, 1999 to September 30, 2000, 9 children with severe adenovirus infection were treated at Chang Gung Children's Hospital. The mean age was 22 months (range, 5-50 months). All of them had lower respiratory tract infections, which manifested as lobar or segmental pneumonia and pleural effusion. Eight (88.9%) of the 9 patients required intensive care and 4 of them required mechanical ventilation. Abnormal laboratory findings included leukocytosis, elevated C-reactive protein, anemia, and prolonged prothrombin time and partial thromboplastin time. Extrapulmonary complications included hepatitis (6 cases), encephalitis (3), conjunctivitis (3), periorbital ecchymosis (1), and coagulopathy (2). One patient died, resulting in a mortality rate of 12.5%. Follow-up at 3 months postdischarge, 5 patients (62.5% of survivors) had bronchiolitis obliterans and/or organizing pneumonia. Seven patients were infected by serotype 3 adenovirus, 1 patient by serotype 2, and another by serotype 11. In conclusion, the clinical, laboratory, and radiographic features of severe adenovirus infection may mimic bacterial infection. Rapid progression of the clinical course despite antibiotic therapy and the presence of unusual extrapulmonary symptoms are important clinical clues in the diagnosis of severe adenoviral infection.

AB - During the period from July 1, 1999 to September 30, 2000, 9 children with severe adenovirus infection were treated at Chang Gung Children's Hospital. The mean age was 22 months (range, 5-50 months). All of them had lower respiratory tract infections, which manifested as lobar or segmental pneumonia and pleural effusion. Eight (88.9%) of the 9 patients required intensive care and 4 of them required mechanical ventilation. Abnormal laboratory findings included leukocytosis, elevated C-reactive protein, anemia, and prolonged prothrombin time and partial thromboplastin time. Extrapulmonary complications included hepatitis (6 cases), encephalitis (3), conjunctivitis (3), periorbital ecchymosis (1), and coagulopathy (2). One patient died, resulting in a mortality rate of 12.5%. Follow-up at 3 months postdischarge, 5 patients (62.5% of survivors) had bronchiolitis obliterans and/or organizing pneumonia. Seven patients were infected by serotype 3 adenovirus, 1 patient by serotype 2, and another by serotype 11. In conclusion, the clinical, laboratory, and radiographic features of severe adenovirus infection may mimic bacterial infection. Rapid progression of the clinical course despite antibiotic therapy and the presence of unusual extrapulmonary symptoms are important clinical clues in the diagnosis of severe adenoviral infection.

KW - Adenovirus

KW - Children

KW - Lower respiratory tract infection

UR - http://www.scopus.com/inward/record.url?scp=0037355324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037355324&partnerID=8YFLogxK

M3 - Article

C2 - 12741731

AN - SCOPUS:0037355324

VL - 36

SP - 37

EP - 40

JO - Journal of Microbiology, Immunology and Infection

JF - Journal of Microbiology, Immunology and Infection

SN - 0253-2662

IS - 1

ER -