Sesquiterpene glycosides from cosmospora joca

Zong-Huei Li, Chung Kuang Lu, Guei Jane Wang, Ya Chih Chang, Wen Bin Yang, Yu Min Ju

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Five novel sesquiterpene glycosides, namely, cosmosporasides A-E (1-5), were isolated from the ethyl acetate extract of the fermented broth of Cosmospora joca. The structures of 1-5 were elucidated on the basis of spectroscopic data analyses, monosaccharide composition analyses, and monosaccharide chirality analyses. The relative configuration of the sesquiterpene moiety of 3-5 was determined by J-based configuration analyses and supported by NOESY assignments. The inhibitory effects of 1-5 on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells were evaluated; all except 3 inhibited NO production at 100 μM. 4 was the most potent, with an average maximum inhibition and a median inhibitory concentration value of 71.70 ± 1.23% and 65.98 ± 0.53 μM, respectively.

Original languageEnglish
Pages (from-to)1561-1567
Number of pages7
JournalJournal of Natural Products
Volume74
Issue number7
DOIs
Publication statusPublished - Jul 22 2011

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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