Sesquiterpene glycosides from cosmospora joca

Zong-Huei Li, Chung Kuang Lu, Guei Jane Wang, Ya Chih Chang, Wen Bin Yang, Yu Min Ju

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Five novel sesquiterpene glycosides, namely, cosmosporasides A-E (1-5), were isolated from the ethyl acetate extract of the fermented broth of Cosmospora joca. The structures of 1-5 were elucidated on the basis of spectroscopic data analyses, monosaccharide composition analyses, and monosaccharide chirality analyses. The relative configuration of the sesquiterpene moiety of 3-5 was determined by J-based configuration analyses and supported by NOESY assignments. The inhibitory effects of 1-5 on the nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW264.7 cells were evaluated; all except 3 inhibited NO production at 100 μM. 4 was the most potent, with an average maximum inhibition and a median inhibitory concentration value of 71.70 ± 1.23% and 65.98 ± 0.53 μM, respectively.

Original languageEnglish
Pages (from-to)1561-1567
Number of pages7
JournalJournal of Natural Products
Volume74
Issue number7
DOIs
Publication statusPublished - Jul 22 2011

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Monosaccharides
Sesquiterpenes
Glycosides
Nitric Oxide
Macrophages
Chirality
Lipopolysaccharides
Chemical analysis
ethyl acetate

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Li, Z-H., Lu, C. K., Wang, G. J., Chang, Y. C., Yang, W. B., & Ju, Y. M. (2011). Sesquiterpene glycosides from cosmospora joca. Journal of Natural Products, 74(7), 1561-1567. https://doi.org/10.1021/np200056e

Sesquiterpene glycosides from cosmospora joca. / Li, Zong-Huei; Lu, Chung Kuang; Wang, Guei Jane; Chang, Ya Chih; Yang, Wen Bin; Ju, Yu Min.

In: Journal of Natural Products, Vol. 74, No. 7, 22.07.2011, p. 1561-1567.

Research output: Contribution to journalArticle

Li, Z-H, Lu, CK, Wang, GJ, Chang, YC, Yang, WB & Ju, YM 2011, 'Sesquiterpene glycosides from cosmospora joca', Journal of Natural Products, vol. 74, no. 7, pp. 1561-1567. https://doi.org/10.1021/np200056e
Li Z-H, Lu CK, Wang GJ, Chang YC, Yang WB, Ju YM. Sesquiterpene glycosides from cosmospora joca. Journal of Natural Products. 2011 Jul 22;74(7):1561-1567. https://doi.org/10.1021/np200056e
Li, Zong-Huei ; Lu, Chung Kuang ; Wang, Guei Jane ; Chang, Ya Chih ; Yang, Wen Bin ; Ju, Yu Min. / Sesquiterpene glycosides from cosmospora joca. In: Journal of Natural Products. 2011 ; Vol. 74, No. 7. pp. 1561-1567.
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