Serum vascular endothelial growth factor165 levels and uterine fibroid volume

Da Chung Chen, Jah Yao Liu, Gwo Jang Wu, Chih Hung Ku, Her Young Su, Chi Huang Chen

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background. Vascular endothelial growth factories (VEGF165) demonstrates increased expression in uterine fibroids. This study aimed to investigate the relationship between serum VEGF165 levels and uterine fibroid volume. Methods. On a prospective observational basis, 80 women with symptomatic uterine fibroids underwent hysterectomy. Uterine weight was determined after hysterectomy. Six hours before and 48 h after hysterectomy, serum VEGF165 levels were measured using an enzyme-linked immunosorbent assay. Results. Logistic regression analysis showed no correlation between serum VEGF165 levels and uterine weight (r = 0.0037; P >0.05). The mean serum VEGF165 level declined significantly from 716.31 ± 457.99 to 581.81 ± 403.32 pg/mL after hysterectomy (P <0.0001). Controlling for age, body mass index, uterine weight, proliferative or secretory phase, and parity, only parous patients (n = 58) were found to have significantly decreased serum VEGF165 levels after hysterectomy (P = 0.000035), in contrast to nulliparous patients (n = 22; P = 0.15). Conclusions. Serum VEGF165 levels do not correlate with uterine fibroid volume, but demonstrate a significant decrease after hysterectomy. The decrease in serum VEGF165 levels after hysterectomy was significant in parous but not in nulliparous patients with uterine fibroids. Serum VEGF165 levels may not predict uterine fibroid development.

Original languageEnglish
Pages (from-to)317-321
Number of pages5
JournalActa Obstetricia et Gynecologica Scandinavica
Volume84
Issue number4
DOIs
Publication statusPublished - Apr 2005
Externally publishedYes

Fingerprint

Leiomyoma
Blood Vessels
Hysterectomy
Growth
Serum
Weights and Measures
Parity
Body Mass Index
Logistic Models
Enzyme-Linked Immunosorbent Assay
Regression Analysis

Keywords

  • Hysterectomy
  • Nulliparous
  • Parous
  • Uterine fibroids
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Serum vascular endothelial growth factor165 levels and uterine fibroid volume. / Chen, Da Chung; Liu, Jah Yao; Wu, Gwo Jang; Ku, Chih Hung; Su, Her Young; Chen, Chi Huang.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 84, No. 4, 04.2005, p. 317-321.

Research output: Contribution to journalArticle

Chen, Da Chung ; Liu, Jah Yao ; Wu, Gwo Jang ; Ku, Chih Hung ; Su, Her Young ; Chen, Chi Huang. / Serum vascular endothelial growth factor165 levels and uterine fibroid volume. In: Acta Obstetricia et Gynecologica Scandinavica. 2005 ; Vol. 84, No. 4. pp. 317-321.
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N2 - Background. Vascular endothelial growth factories (VEGF165) demonstrates increased expression in uterine fibroids. This study aimed to investigate the relationship between serum VEGF165 levels and uterine fibroid volume. Methods. On a prospective observational basis, 80 women with symptomatic uterine fibroids underwent hysterectomy. Uterine weight was determined after hysterectomy. Six hours before and 48 h after hysterectomy, serum VEGF165 levels were measured using an enzyme-linked immunosorbent assay. Results. Logistic regression analysis showed no correlation between serum VEGF165 levels and uterine weight (r = 0.0037; P >0.05). The mean serum VEGF165 level declined significantly from 716.31 ± 457.99 to 581.81 ± 403.32 pg/mL after hysterectomy (P <0.0001). Controlling for age, body mass index, uterine weight, proliferative or secretory phase, and parity, only parous patients (n = 58) were found to have significantly decreased serum VEGF165 levels after hysterectomy (P = 0.000035), in contrast to nulliparous patients (n = 22; P = 0.15). Conclusions. Serum VEGF165 levels do not correlate with uterine fibroid volume, but demonstrate a significant decrease after hysterectomy. The decrease in serum VEGF165 levels after hysterectomy was significant in parous but not in nulliparous patients with uterine fibroids. Serum VEGF165 levels may not predict uterine fibroid development.

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