Serum vascular endothelial growth factor-D levels correlate with cervical lymph node metastases in papillary thyroid carcinoma

Chieh Wen Lai, Kuen Yuan Chen, Chin Sheng Hung, Shi Wen Kuo, Yao Jen Chang, Ming Tsan Lin, Kun Che Chang, Ming Hsun Wu

Research output: Contribution to journalArticle

5 Citations (Scopus)


The aim of this multicenter study was to evaluate the clinical relevance of serum vascular endothelial growth factor-D (VEGF-D) in papillary thyroid carcinoma (PTC). This prospective study consisted of 74 patients with primary PTC and 15 patients with benign thyroid nodules treated from 2008 to 2009. VEGF-D concentration was compared with patient clinicopathologic features and lymph node metastases. There was no significant difference in mean serum VEGF-D levels between the PTC and benign thyroid nodule groups. Within the PTC group, serum VEGF-D levels were significantly higher in patients with lymph node metastases than in patients without metastases (241.92 vs. 213.89 pg/ml, respectively; P = 0.035). Receiver operating characteristic curve analysis revealed that preoperative serum VEGF-D levels were predictive of lymph node metastases in the patients >45 years. Serum VEGF-D level that was correlated with the presence of cervical lymph node metastases in PTC patients might be a useful prognostic indicator.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalGrowth Factors
Issue number2-3
Publication statusPublished - Apr 2011



  • lymph node
  • metastasis
  • Papillary thyroid cancer
  • serum marker
  • VEGF-D

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Endocrinology
  • Cell Biology

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