Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes

Hung Yuan Li, Hung An Lin, Feng Jung Nien, Vin Cent Wu, Yi Der Jiang, Tien Jyun Chang, Hsien Li Kao, Mao Shin Lin, Jung Nan Wei, Cheng Hsin Lin, Shyang Rong Shih, Chi Sheng Hung, Lee Ming Chuang

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12 Citations (Scopus)

Abstract

Background Diabetes is the leading cause of end-stage renal disease (ESRD) worldwide. Vascular adhesion protein-1 (VAP-1) participates in inflammation and catalyzes the deamination of primary amines into aldehydes, hydrogen peroxide, and ammonia, both of which are involved in the pathogenesis of diabetic complications. We have shown that serum VAP-1 is higher in patients with diabetes and in patients with chronic kidney disease (CKD), and can predict cardiovascular mortality in subjects with diabetes. In this study, we investigated if serum VAP-1 can predict ESRD in diabetic subjects. Methods In this prospective cohort study, a total of 604 type 2 diabetic subjects were enrolled between 1996 to 2003 at National Taiwan University Hospital, Taiwan, and were followed for a median of 12.36 years. The development of ESRD was ascertained by linking our database with the nationally comprehensive Taiwan Society Nephrology registry. Serum VAP-1 concentrations at enrollment were measured by time-resolved immunofluorometric assay. Results Subjects with serum VAP-1 in the highest tertile had the highest incidence of ESRD (p

Original languageEnglish
Article numbere0147981
JournalPLoS One
Volume11
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Li, H. Y., Lin, H. A., Nien, F. J., Wu, V. C., Jiang, Y. D., Chang, T. J., Kao, H. L., Lin, M. S., Wei, J. N., Lin, C. H., Shih, S. R., Hung, C. S., & Chuang, L. M. (2016). Serum Vascular Adhesion Protein-1 Predicts End-Stage Renal Disease in Patients with Type 2 Diabetes. PLoS One, 11(2), [e0147981]. https://doi.org/10.1371/journal.pone.0147981