Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively

Chun Heng Kuo, Jung Nan Wei, Chung Yi Yang, Horng Yih Ou, Hung Tsung Wu, Kang Chih Fan, Shu Huei Wang, Cyue Huei Hua, Ching Hsiang Hsiao, Mei Kuei Lee, Hung Yuan Li

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Abstract

Background/objectives: Vascular adhesion protein-1 (VAP-1) can enhance tissue glucose uptake in cell studies and normalize hyperglycemia in animal studies. However, serum VAP-1 concentration (sVAP-1) is higher in subjects with diabetes in cross-sectional studies. In this cohort study, we test our hypothesis that sVAP-1 is increased in prediabetes to counteract hyperglycemia and is associated with incident diabetes negatively. Subjects/methods: From 2006 to 2012, 600 subjects without diabetes from Taiwan Lifestyle Study were included and followed regularly. Diabetes was diagnosed if FPG ≥ 126 mg/dL (7 mmol/L), 2-h plasma glucose (2hPG) during an oral glucose tolerance test (OGTT) ≥ 200 mg/dL (11.1 mmol/L), or hemoglobin A1c (HbA1c) ≥ 6.5%, or if the subject received anti-diabetic medications. Abdominal fat areas were measured by abdominal computed tomography and sVAP-1 was analyzed by ELISA. Results: sVAP-1 was higher in subjects with prediabetes (p < 0.05) and increased during an OGTT (p < 0.001). Fasting sVAP-1 was associated with the response of sVAP-1 during an OGTT (p < 0.001). Besides, sVAP-1 was associated negatively with body mass index (BMI, r = −0.1449, p = 0.003), waist circumference (r = −0.1425, p = 0.004), abdominal visceral (r = −0.1457, p = 0.003), and subcutaneous (r = −0.1025, p = 0.035) fat areas, and serum high-sensitivity C-reactive protein (hsCRP) concentration (r = −0.2035, p < 0.0001), and positively with plasma adiponectin concentration (r = 0.2086, p < 0.0001), adjusted for age and gender. After 4.7 ± 2.6 years, 73 subjects (12.2%) developed incident diabetes. High sVAP-1 predicted a lower incidence of diabetes, adjusted for age, gender, BMI, family history of diabetes, HbA1c, HOMA2-%B and HOMA2-IR (HR = 0.66, 95% CI = 0.50–0.88, p < 0.01). Conclusions: sVAP-1 is increased in response to hyperglycemia. It is associated with obesity and serum hsCRP concentration negatively, and plasma adiponectin concentration positively. Besides, a high sVAP-1 is associated with a lower incidence of diabetes in human.

Original languageEnglish
JournalInternational Journal of Obesity
DOIs
Publication statusPublished - Mar 2019

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Hyperglycemia
Blood Vessels
Serum
Proteins
Glucose Tolerance Test
Prediabetic State
Adiponectin
C-Reactive Protein
Hemoglobins
human AOC3 protein
Glucose
Abdominal Fat
Incidence
Waist Circumference
Taiwan
Life Style
Fasting
Body Mass Index
Cohort Studies
Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively. / Kuo, Chun Heng; Wei, Jung Nan; Yang, Chung Yi; Ou, Horng Yih; Wu, Hung Tsung; Fan, Kang Chih; Wang, Shu Huei; Hua, Cyue Huei; Hsiao, Ching Hsiang; Lee, Mei Kuei; Li, Hung Yuan.

In: International Journal of Obesity, 03.2019.

Research output: Contribution to journalArticle

Kuo, Chun Heng ; Wei, Jung Nan ; Yang, Chung Yi ; Ou, Horng Yih ; Wu, Hung Tsung ; Fan, Kang Chih ; Wang, Shu Huei ; Hua, Cyue Huei ; Hsiao, Ching Hsiang ; Lee, Mei Kuei ; Li, Hung Yuan. / Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively. In: International Journal of Obesity. 2019.
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title = "Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively",
abstract = "Background/objectives: Vascular adhesion protein-1 (VAP-1) can enhance tissue glucose uptake in cell studies and normalize hyperglycemia in animal studies. However, serum VAP-1 concentration (sVAP-1) is higher in subjects with diabetes in cross-sectional studies. In this cohort study, we test our hypothesis that sVAP-1 is increased in prediabetes to counteract hyperglycemia and is associated with incident diabetes negatively. Subjects/methods: From 2006 to 2012, 600 subjects without diabetes from Taiwan Lifestyle Study were included and followed regularly. Diabetes was diagnosed if FPG ≥ 126 mg/dL (7 mmol/L), 2-h plasma glucose (2hPG) during an oral glucose tolerance test (OGTT) ≥ 200 mg/dL (11.1 mmol/L), or hemoglobin A1c (HbA1c) ≥ 6.5{\%}, or if the subject received anti-diabetic medications. Abdominal fat areas were measured by abdominal computed tomography and sVAP-1 was analyzed by ELISA. Results: sVAP-1 was higher in subjects with prediabetes (p < 0.05) and increased during an OGTT (p < 0.001). Fasting sVAP-1 was associated with the response of sVAP-1 during an OGTT (p < 0.001). Besides, sVAP-1 was associated negatively with body mass index (BMI, r = −0.1449, p = 0.003), waist circumference (r = −0.1425, p = 0.004), abdominal visceral (r = −0.1457, p = 0.003), and subcutaneous (r = −0.1025, p = 0.035) fat areas, and serum high-sensitivity C-reactive protein (hsCRP) concentration (r = −0.2035, p < 0.0001), and positively with plasma adiponectin concentration (r = 0.2086, p < 0.0001), adjusted for age and gender. After 4.7 ± 2.6 years, 73 subjects (12.2{\%}) developed incident diabetes. High sVAP-1 predicted a lower incidence of diabetes, adjusted for age, gender, BMI, family history of diabetes, HbA1c, HOMA2-{\%}B and HOMA2-IR (HR = 0.66, 95{\%} CI = 0.50–0.88, p < 0.01). Conclusions: sVAP-1 is increased in response to hyperglycemia. It is associated with obesity and serum hsCRP concentration negatively, and plasma adiponectin concentration positively. Besides, a high sVAP-1 is associated with a lower incidence of diabetes in human.",
author = "Kuo, {Chun Heng} and Wei, {Jung Nan} and Yang, {Chung Yi} and Ou, {Horng Yih} and Wu, {Hung Tsung} and Fan, {Kang Chih} and Wang, {Shu Huei} and Hua, {Cyue Huei} and Hsiao, {Ching Hsiang} and Lee, {Mei Kuei} and Li, {Hung Yuan}",
year = "2019",
month = "3",
doi = "10.1038/s41366-018-0172-4",
language = "English",
journal = "International Journal of Obesity",
issn = "0307-0565",
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T1 - Serum vascular adhesion protein-1 is up-regulated in hyperglycemia and is associated with incident diabetes negatively

AU - Kuo, Chun Heng

AU - Wei, Jung Nan

AU - Yang, Chung Yi

AU - Ou, Horng Yih

AU - Wu, Hung Tsung

AU - Fan, Kang Chih

AU - Wang, Shu Huei

AU - Hua, Cyue Huei

AU - Hsiao, Ching Hsiang

AU - Lee, Mei Kuei

AU - Li, Hung Yuan

PY - 2019/3

Y1 - 2019/3

N2 - Background/objectives: Vascular adhesion protein-1 (VAP-1) can enhance tissue glucose uptake in cell studies and normalize hyperglycemia in animal studies. However, serum VAP-1 concentration (sVAP-1) is higher in subjects with diabetes in cross-sectional studies. In this cohort study, we test our hypothesis that sVAP-1 is increased in prediabetes to counteract hyperglycemia and is associated with incident diabetes negatively. Subjects/methods: From 2006 to 2012, 600 subjects without diabetes from Taiwan Lifestyle Study were included and followed regularly. Diabetes was diagnosed if FPG ≥ 126 mg/dL (7 mmol/L), 2-h plasma glucose (2hPG) during an oral glucose tolerance test (OGTT) ≥ 200 mg/dL (11.1 mmol/L), or hemoglobin A1c (HbA1c) ≥ 6.5%, or if the subject received anti-diabetic medications. Abdominal fat areas were measured by abdominal computed tomography and sVAP-1 was analyzed by ELISA. Results: sVAP-1 was higher in subjects with prediabetes (p < 0.05) and increased during an OGTT (p < 0.001). Fasting sVAP-1 was associated with the response of sVAP-1 during an OGTT (p < 0.001). Besides, sVAP-1 was associated negatively with body mass index (BMI, r = −0.1449, p = 0.003), waist circumference (r = −0.1425, p = 0.004), abdominal visceral (r = −0.1457, p = 0.003), and subcutaneous (r = −0.1025, p = 0.035) fat areas, and serum high-sensitivity C-reactive protein (hsCRP) concentration (r = −0.2035, p < 0.0001), and positively with plasma adiponectin concentration (r = 0.2086, p < 0.0001), adjusted for age and gender. After 4.7 ± 2.6 years, 73 subjects (12.2%) developed incident diabetes. High sVAP-1 predicted a lower incidence of diabetes, adjusted for age, gender, BMI, family history of diabetes, HbA1c, HOMA2-%B and HOMA2-IR (HR = 0.66, 95% CI = 0.50–0.88, p < 0.01). Conclusions: sVAP-1 is increased in response to hyperglycemia. It is associated with obesity and serum hsCRP concentration negatively, and plasma adiponectin concentration positively. Besides, a high sVAP-1 is associated with a lower incidence of diabetes in human.

AB - Background/objectives: Vascular adhesion protein-1 (VAP-1) can enhance tissue glucose uptake in cell studies and normalize hyperglycemia in animal studies. However, serum VAP-1 concentration (sVAP-1) is higher in subjects with diabetes in cross-sectional studies. In this cohort study, we test our hypothesis that sVAP-1 is increased in prediabetes to counteract hyperglycemia and is associated with incident diabetes negatively. Subjects/methods: From 2006 to 2012, 600 subjects without diabetes from Taiwan Lifestyle Study were included and followed regularly. Diabetes was diagnosed if FPG ≥ 126 mg/dL (7 mmol/L), 2-h plasma glucose (2hPG) during an oral glucose tolerance test (OGTT) ≥ 200 mg/dL (11.1 mmol/L), or hemoglobin A1c (HbA1c) ≥ 6.5%, or if the subject received anti-diabetic medications. Abdominal fat areas were measured by abdominal computed tomography and sVAP-1 was analyzed by ELISA. Results: sVAP-1 was higher in subjects with prediabetes (p < 0.05) and increased during an OGTT (p < 0.001). Fasting sVAP-1 was associated with the response of sVAP-1 during an OGTT (p < 0.001). Besides, sVAP-1 was associated negatively with body mass index (BMI, r = −0.1449, p = 0.003), waist circumference (r = −0.1425, p = 0.004), abdominal visceral (r = −0.1457, p = 0.003), and subcutaneous (r = −0.1025, p = 0.035) fat areas, and serum high-sensitivity C-reactive protein (hsCRP) concentration (r = −0.2035, p < 0.0001), and positively with plasma adiponectin concentration (r = 0.2086, p < 0.0001), adjusted for age and gender. After 4.7 ± 2.6 years, 73 subjects (12.2%) developed incident diabetes. High sVAP-1 predicted a lower incidence of diabetes, adjusted for age, gender, BMI, family history of diabetes, HbA1c, HOMA2-%B and HOMA2-IR (HR = 0.66, 95% CI = 0.50–0.88, p < 0.01). Conclusions: sVAP-1 is increased in response to hyperglycemia. It is associated with obesity and serum hsCRP concentration negatively, and plasma adiponectin concentration positively. Besides, a high sVAP-1 is associated with a lower incidence of diabetes in human.

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