Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia

Hung Yuan Li, Jung Nan Wei, Mao Shin Lin, David J. Smith, Jani Vainio, Cheng Hsin Lin, Fu Tien Chiang, Shyang Rong Shih, Ching Huei Huang, Mei Yu Wu, Yenh Chen Hsein, Lee Ming Chuang

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Abstract

Background: The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-naïve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes. Methods: Adults without history of diabetes were included. Subjects taking anti-diabetic drugs were excluded. Serum VAP-1 was analyzed by time-resolved immunofluorometric assay. Results: We recruited 333 subjects (186 females and 147 males), aged 56.1 ± 11.6 y. After glucose challenge, serum VAP-1 rose significantly at 30 min (p <0.0001) and lasted until 2 h (p <0.0001). The change of serum VAP-1 between fasting and 30-min postload correlated inversely to the change of plasma insulin (r = - 0.21, p = 0.049). Fasting serum VAP-1 was associated with FPG in those with FPG ≥ 5.55 mmol/l (p = 0.025) but not in those with FPG <5.55 mmol/l (p = NS). Fasting serum VAP-1 were higher in diabetic subjects (p = 0.04) and correlated positively to hemoglobin A1c (r = 0.18, p = 0.002) after adjusting for age, gender, and waist circumference. Conclusions: Serum VAP-1 is increased in both acute and chronic hyperglycemia. Whether serum VAP-1 is a good biomarker for hyperglycemia-associated complications merits further investigation.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalClinica Chimica Acta
Volume404
Issue number2
DOIs
Publication statusPublished - Jun 27 2009
Externally publishedYes

Fingerprint

Hyperglycemia
Blood Vessels
Adhesion
Fasting
Serum
Glucose
Proteins
Plasmas
Medical problems
Type 2 Diabetes Mellitus
Hemoglobins
Fluoroimmunoassay
Waist Circumference
Biomarkers
Pharmaceutical Preparations
Blood Proteins
Assays
Insulin

Keywords

  • Amine oxidase
  • Copper-containing 3 (AOC3)
  • Diabetes mellitus
  • Diabetic complications
  • Semicarbazide-sensitive amine oxidase
  • Vascular adhesion protein-1

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Li, H. Y., Wei, J. N., Lin, M. S., Smith, D. J., Vainio, J., Lin, C. H., ... Chuang, L. M. (2009). Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia. Clinica Chimica Acta, 404(2), 149-153. https://doi.org/10.1016/j.cca.2009.03.041

Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia. / Li, Hung Yuan; Wei, Jung Nan; Lin, Mao Shin; Smith, David J.; Vainio, Jani; Lin, Cheng Hsin; Chiang, Fu Tien; Shih, Shyang Rong; Huang, Ching Huei; Wu, Mei Yu; Hsein, Yenh Chen; Chuang, Lee Ming.

In: Clinica Chimica Acta, Vol. 404, No. 2, 27.06.2009, p. 149-153.

Research output: Contribution to journalArticle

Li, HY, Wei, JN, Lin, MS, Smith, DJ, Vainio, J, Lin, CH, Chiang, FT, Shih, SR, Huang, CH, Wu, MY, Hsein, YC & Chuang, LM 2009, 'Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia', Clinica Chimica Acta, vol. 404, no. 2, pp. 149-153. https://doi.org/10.1016/j.cca.2009.03.041
Li, Hung Yuan ; Wei, Jung Nan ; Lin, Mao Shin ; Smith, David J. ; Vainio, Jani ; Lin, Cheng Hsin ; Chiang, Fu Tien ; Shih, Shyang Rong ; Huang, Ching Huei ; Wu, Mei Yu ; Hsein, Yenh Chen ; Chuang, Lee Ming. / Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia. In: Clinica Chimica Acta. 2009 ; Vol. 404, No. 2. pp. 149-153.
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abstract = "Background: The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-na{\"i}ve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes. Methods: Adults without history of diabetes were included. Subjects taking anti-diabetic drugs were excluded. Serum VAP-1 was analyzed by time-resolved immunofluorometric assay. Results: We recruited 333 subjects (186 females and 147 males), aged 56.1 ± 11.6 y. After glucose challenge, serum VAP-1 rose significantly at 30 min (p <0.0001) and lasted until 2 h (p <0.0001). The change of serum VAP-1 between fasting and 30-min postload correlated inversely to the change of plasma insulin (r = - 0.21, p = 0.049). Fasting serum VAP-1 was associated with FPG in those with FPG ≥ 5.55 mmol/l (p = 0.025) but not in those with FPG <5.55 mmol/l (p = NS). Fasting serum VAP-1 were higher in diabetic subjects (p = 0.04) and correlated positively to hemoglobin A1c (r = 0.18, p = 0.002) after adjusting for age, gender, and waist circumference. Conclusions: Serum VAP-1 is increased in both acute and chronic hyperglycemia. Whether serum VAP-1 is a good biomarker for hyperglycemia-associated complications merits further investigation.",
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T1 - Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia

AU - Li, Hung Yuan

AU - Wei, Jung Nan

AU - Lin, Mao Shin

AU - Smith, David J.

AU - Vainio, Jani

AU - Lin, Cheng Hsin

AU - Chiang, Fu Tien

AU - Shih, Shyang Rong

AU - Huang, Ching Huei

AU - Wu, Mei Yu

AU - Hsein, Yenh Chen

AU - Chuang, Lee Ming

PY - 2009/6/27

Y1 - 2009/6/27

N2 - Background: The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-naïve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes. Methods: Adults without history of diabetes were included. Subjects taking anti-diabetic drugs were excluded. Serum VAP-1 was analyzed by time-resolved immunofluorometric assay. Results: We recruited 333 subjects (186 females and 147 males), aged 56.1 ± 11.6 y. After glucose challenge, serum VAP-1 rose significantly at 30 min (p <0.0001) and lasted until 2 h (p <0.0001). The change of serum VAP-1 between fasting and 30-min postload correlated inversely to the change of plasma insulin (r = - 0.21, p = 0.049). Fasting serum VAP-1 was associated with FPG in those with FPG ≥ 5.55 mmol/l (p = 0.025) but not in those with FPG <5.55 mmol/l (p = NS). Fasting serum VAP-1 were higher in diabetic subjects (p = 0.04) and correlated positively to hemoglobin A1c (r = 0.18, p = 0.002) after adjusting for age, gender, and waist circumference. Conclusions: Serum VAP-1 is increased in both acute and chronic hyperglycemia. Whether serum VAP-1 is a good biomarker for hyperglycemia-associated complications merits further investigation.

AB - Background: The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-naïve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes. Methods: Adults without history of diabetes were included. Subjects taking anti-diabetic drugs were excluded. Serum VAP-1 was analyzed by time-resolved immunofluorometric assay. Results: We recruited 333 subjects (186 females and 147 males), aged 56.1 ± 11.6 y. After glucose challenge, serum VAP-1 rose significantly at 30 min (p <0.0001) and lasted until 2 h (p <0.0001). The change of serum VAP-1 between fasting and 30-min postload correlated inversely to the change of plasma insulin (r = - 0.21, p = 0.049). Fasting serum VAP-1 was associated with FPG in those with FPG ≥ 5.55 mmol/l (p = 0.025) but not in those with FPG <5.55 mmol/l (p = NS). Fasting serum VAP-1 were higher in diabetic subjects (p = 0.04) and correlated positively to hemoglobin A1c (r = 0.18, p = 0.002) after adjusting for age, gender, and waist circumference. Conclusions: Serum VAP-1 is increased in both acute and chronic hyperglycemia. Whether serum VAP-1 is a good biomarker for hyperglycemia-associated complications merits further investigation.

KW - Amine oxidase

KW - Copper-containing 3 (AOC3)

KW - Diabetes mellitus

KW - Diabetic complications

KW - Semicarbazide-sensitive amine oxidase

KW - Vascular adhesion protein-1

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