Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia

Hung Yuan Li, Jung Nan Wei, Mao Shin Lin, David J. Smith, Jani Vainio, Cheng Hsin Lin, Fu Tien Chiang, Shyang Rong Shih, Ching Huei Huang, Mei Yu Wu, Yenh Chen Hsein, Lee Ming Chuang

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Abstract

Background: The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-naïve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes. Methods: Adults without history of diabetes were included. Subjects taking anti-diabetic drugs were excluded. Serum VAP-1 was analyzed by time-resolved immunofluorometric assay. Results: We recruited 333 subjects (186 females and 147 males), aged 56.1 ± 11.6 y. After glucose challenge, serum VAP-1 rose significantly at 30 min (p <0.0001) and lasted until 2 h (p <0.0001). The change of serum VAP-1 between fasting and 30-min postload correlated inversely to the change of plasma insulin (r = - 0.21, p = 0.049). Fasting serum VAP-1 was associated with FPG in those with FPG ≥ 5.55 mmol/l (p = 0.025) but not in those with FPG <5.55 mmol/l (p = NS). Fasting serum VAP-1 were higher in diabetic subjects (p = 0.04) and correlated positively to hemoglobin A1c (r = 0.18, p = 0.002) after adjusting for age, gender, and waist circumference. Conclusions: Serum VAP-1 is increased in both acute and chronic hyperglycemia. Whether serum VAP-1 is a good biomarker for hyperglycemia-associated complications merits further investigation.

Original languageEnglish
Pages (from-to)149-153
Number of pages5
JournalClinica Chimica Acta
Volume404
Issue number2
DOIs
Publication statusPublished - Jun 27 2009
Externally publishedYes

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Keywords

  • Amine oxidase
  • Copper-containing 3 (AOC3)
  • Diabetes mellitus
  • Diabetic complications
  • Semicarbazide-sensitive amine oxidase
  • Vascular adhesion protein-1

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Li, H. Y., Wei, J. N., Lin, M. S., Smith, D. J., Vainio, J., Lin, C. H., Chiang, F. T., Shih, S. R., Huang, C. H., Wu, M. Y., Hsein, Y. C., & Chuang, L. M. (2009). Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia. Clinica Chimica Acta, 404(2), 149-153. https://doi.org/10.1016/j.cca.2009.03.041