Serum vascular adhesion protein-1 is higher in subjects with early stages of chronic kidney disease

Mao Shin Lin, Hung Yuan Li, Jung Nan Wei, Cheng Hsin Lin, David J. Smith, Jani Vainio, Shyang Rong Shih, Ying Hui Chen, Lung Chun Lin, Hsien Li Kao, Lee Ming Chuang, Ming Fong Chen

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Abstract

Objectives: An increased level of serum vascular adhesion protein-1 (VAP-1) has been found in patients with diabetes mellitus and vascular disorders. This study examined whether serum VAP-1 levels are associated with chronic kidney disease (CKD). Design and methods: We included 262 subjects aged 30 and above with fasting plasma glucose level <7 mmol/L checked within 1 year. First morning urine specimens were collected. Microalbuminuria was defined if urinary albumin-to-creatinine ratio ≥ 30 μg/mg creatinine. The glomerular filtration rate (GFR) was estimated. CKD stages were defined according to the suggestions of the National Kidney Foundation. Serum VAP-1 levels were analyzed by immunofluorometric assay. Results: Serum VAP-1 levels were positively associated with the urinary albumin-to-creatinine ratio ( r = 0.29, p <0.0001) and negatively associated with estimated GFR (r = -0.24, p = 0.0001). Subjects with CKD stage 2 (N = 51) and stage 3 (N = 91) had significantly higher levels of serum VAP-1 than those without CKD (p = 0.0003 and p = 0.035, adjusted for age and gender, respectively). A high serum VAP-1 level was associated with the presence of CKD (OR 1.63 for 1 SD increase of VAP-1, p = 0.018), adjusting for age, sex, and smoking. Ordered logit models revealed that high serum VAP-1 levels correlated with advanced stages of CKD. Conclusions: Serum levels of VAP-1 are associated with the severity of kidney damage or stages of kidney disease. The true mechanism which links the serum VAP-1 and CKD remains to be elucidated in further studies.

Original languageEnglish
Pages (from-to)1362-1367
Number of pages6
JournalClinical Biochemistry
Volume41
Issue number16-17
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

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Keywords

  • Amine oxidase
  • Chronic kidney disease
  • Microalbuminuria
  • SSAO
  • Vascular adhesion protein-1

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Lin, M. S., Li, H. Y., Wei, J. N., Lin, C. H., Smith, D. J., Vainio, J., Shih, S. R., Chen, Y. H., Lin, L. C., Kao, H. L., Chuang, L. M., & Chen, M. F. (2008). Serum vascular adhesion protein-1 is higher in subjects with early stages of chronic kidney disease. Clinical Biochemistry, 41(16-17), 1362-1367. https://doi.org/10.1016/j.clinbiochem.2008.06.019