Serum vascular adhesion protein-1 is higher in subjects with early stages of chronic kidney disease

Mao Shin Lin; Hung Yuan Li; Jung Nan Wei; Cheng Hsin Lin; David J. Smith; Jani Vainio; Shyang Rong Shih; Ying Hui Chen; Lung Chun Lin; Hsien Li Kao; Lee Ming Chuang; Ming Fong Chen

doi:10.1016/j.clinbiochem.2008.06.019

Serum vascular adhesion protein-1 is higher in subjects with early stages of chronic kidney disease

Mao Shin Lin, Hung Yuan Li, Jung Nan Wei, Cheng Hsin Lin, David J. Smith, Jani Vainio, Shyang Rong Shih, Ying Hui Chen, Lung Chun Lin, Hsien Li Kao, Lee Ming Chuang, Ming Fong Chen

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Objectives: An increased level of serum vascular adhesion protein-1 (VAP-1) has been found in patients with diabetes mellitus and vascular disorders. This study examined whether serum VAP-1 levels are associated with chronic kidney disease (CKD). Design and methods: We included 262 subjects aged 30 and above with fasting plasma glucose level < 7 mmol/L checked within 1 year. First morning urine specimens were collected. Microalbuminuria was defined if urinary albumin-to-creatinine ratio ≥ 30 μg/mg creatinine. The glomerular filtration rate (GFR) was estimated. CKD stages were defined according to the suggestions of the National Kidney Foundation. Serum VAP-1 levels were analyzed by immunofluorometric assay. Results: Serum VAP-1 levels were positively associated with the urinary albumin-to-creatinine ratio ( r = 0.29, p < 0.0001) and negatively associated with estimated GFR (r = -0.24, p = 0.0001). Subjects with CKD stage 2 (N = 51) and stage 3 (N = 91) had significantly higher levels of serum VAP-1 than those without CKD (p = 0.0003 and p = 0.035, adjusted for age and gender, respectively). A high serum VAP-1 level was associated with the presence of CKD (OR 1.63 for 1 SD increase of VAP-1, p = 0.018), adjusting for age, sex, and smoking. Ordered logit models revealed that high serum VAP-1 levels correlated with advanced stages of CKD. Conclusions: Serum levels of VAP-1 are associated with the severity of kidney damage or stages of kidney disease. The true mechanism which links the serum VAP-1 and CKD remains to be elucidated in further studies.

Original language	English
Pages (from-to)	1362-1367
Number of pages	6
Journal	Clinical Biochemistry
Volume	41
Issue number	16-17
DOIs	https://doi.org/10.1016/j.clinbiochem.2008.06.019
Publication status	Published - Nov 2008
Externally published	Yes

Keywords

Amine oxidase
Chronic kidney disease
Microalbuminuria
SSAO
Vascular adhesion protein-1

ASJC Scopus subject areas

Clinical Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.clinbiochem.2008.06.019

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@article{9e80dada0f0f404f94466889eff7dc5e,

title = "Serum vascular adhesion protein-1 is higher in subjects with early stages of chronic kidney disease",

abstract = "Objectives: An increased level of serum vascular adhesion protein-1 (VAP-1) has been found in patients with diabetes mellitus and vascular disorders. This study examined whether serum VAP-1 levels are associated with chronic kidney disease (CKD). Design and methods: We included 262 subjects aged 30 and above with fasting plasma glucose level < 7 mmol/L checked within 1 year. First morning urine specimens were collected. Microalbuminuria was defined if urinary albumin-to-creatinine ratio ≥ 30 μg/mg creatinine. The glomerular filtration rate (GFR) was estimated. CKD stages were defined according to the suggestions of the National Kidney Foundation. Serum VAP-1 levels were analyzed by immunofluorometric assay. Results: Serum VAP-1 levels were positively associated with the urinary albumin-to-creatinine ratio ( r = 0.29, p < 0.0001) and negatively associated with estimated GFR (r = -0.24, p = 0.0001). Subjects with CKD stage 2 (N = 51) and stage 3 (N = 91) had significantly higher levels of serum VAP-1 than those without CKD (p = 0.0003 and p = 0.035, adjusted for age and gender, respectively). A high serum VAP-1 level was associated with the presence of CKD (OR 1.63 for 1 SD increase of VAP-1, p = 0.018), adjusting for age, sex, and smoking. Ordered logit models revealed that high serum VAP-1 levels correlated with advanced stages of CKD. Conclusions: Serum levels of VAP-1 are associated with the severity of kidney damage or stages of kidney disease. The true mechanism which links the serum VAP-1 and CKD remains to be elucidated in further studies.",

keywords = "Amine oxidase, Chronic kidney disease, Microalbuminuria, SSAO, Vascular adhesion protein-1",

author = "Lin, {Mao Shin} and Li, {Hung Yuan} and Wei, {Jung Nan} and Lin, {Cheng Hsin} and Smith, {David J.} and Jani Vainio and Shih, {Shyang Rong} and Chen, {Ying Hui} and Lin, {Lung Chun} and Kao, {Hsien Li} and Chuang, {Lee Ming} and Chen, {Ming Fong}",

note = "Funding Information: The authors would like to thank Ms. Cyue-Huei Hua and Ms. Kuan-Yi Wu for their technical and computing assistance. This work is supported in part by grants from the National Science Council, Taiwan (NSC 96-2314-B-002-035-MY2) and from the Yunlin branch, National Taiwan University Hospital, Taiwan (NTUHYL95.N004 and N009). ",

year = "2008",

month = nov,

doi = "10.1016/j.clinbiochem.2008.06.019",

language = "English",

volume = "41",

pages = "1362--1367",

journal = "Clinical Biochemistry",

issn = "0009-9120",

publisher = "Elsevier Inc.",

number = "16-17",

}

TY - JOUR

T1 - Serum vascular adhesion protein-1 is higher in subjects with early stages of chronic kidney disease

AU - Lin, Mao Shin

AU - Li, Hung Yuan

AU - Wei, Jung Nan

AU - Lin, Cheng Hsin

AU - Smith, David J.

AU - Vainio, Jani

AU - Shih, Shyang Rong

AU - Chen, Ying Hui

AU - Lin, Lung Chun

AU - Kao, Hsien Li

AU - Chuang, Lee Ming

AU - Chen, Ming Fong

N1 - Funding Information: The authors would like to thank Ms. Cyue-Huei Hua and Ms. Kuan-Yi Wu for their technical and computing assistance. This work is supported in part by grants from the National Science Council, Taiwan (NSC 96-2314-B-002-035-MY2) and from the Yunlin branch, National Taiwan University Hospital, Taiwan (NTUHYL95.N004 and N009).

PY - 2008/11

Y1 - 2008/11

N2 - Objectives: An increased level of serum vascular adhesion protein-1 (VAP-1) has been found in patients with diabetes mellitus and vascular disorders. This study examined whether serum VAP-1 levels are associated with chronic kidney disease (CKD). Design and methods: We included 262 subjects aged 30 and above with fasting plasma glucose level < 7 mmol/L checked within 1 year. First morning urine specimens were collected. Microalbuminuria was defined if urinary albumin-to-creatinine ratio ≥ 30 μg/mg creatinine. The glomerular filtration rate (GFR) was estimated. CKD stages were defined according to the suggestions of the National Kidney Foundation. Serum VAP-1 levels were analyzed by immunofluorometric assay. Results: Serum VAP-1 levels were positively associated with the urinary albumin-to-creatinine ratio ( r = 0.29, p < 0.0001) and negatively associated with estimated GFR (r = -0.24, p = 0.0001). Subjects with CKD stage 2 (N = 51) and stage 3 (N = 91) had significantly higher levels of serum VAP-1 than those without CKD (p = 0.0003 and p = 0.035, adjusted for age and gender, respectively). A high serum VAP-1 level was associated with the presence of CKD (OR 1.63 for 1 SD increase of VAP-1, p = 0.018), adjusting for age, sex, and smoking. Ordered logit models revealed that high serum VAP-1 levels correlated with advanced stages of CKD. Conclusions: Serum levels of VAP-1 are associated with the severity of kidney damage or stages of kidney disease. The true mechanism which links the serum VAP-1 and CKD remains to be elucidated in further studies.

AB - Objectives: An increased level of serum vascular adhesion protein-1 (VAP-1) has been found in patients with diabetes mellitus and vascular disorders. This study examined whether serum VAP-1 levels are associated with chronic kidney disease (CKD). Design and methods: We included 262 subjects aged 30 and above with fasting plasma glucose level < 7 mmol/L checked within 1 year. First morning urine specimens were collected. Microalbuminuria was defined if urinary albumin-to-creatinine ratio ≥ 30 μg/mg creatinine. The glomerular filtration rate (GFR) was estimated. CKD stages were defined according to the suggestions of the National Kidney Foundation. Serum VAP-1 levels were analyzed by immunofluorometric assay. Results: Serum VAP-1 levels were positively associated with the urinary albumin-to-creatinine ratio ( r = 0.29, p < 0.0001) and negatively associated with estimated GFR (r = -0.24, p = 0.0001). Subjects with CKD stage 2 (N = 51) and stage 3 (N = 91) had significantly higher levels of serum VAP-1 than those without CKD (p = 0.0003 and p = 0.035, adjusted for age and gender, respectively). A high serum VAP-1 level was associated with the presence of CKD (OR 1.63 for 1 SD increase of VAP-1, p = 0.018), adjusting for age, sex, and smoking. Ordered logit models revealed that high serum VAP-1 levels correlated with advanced stages of CKD. Conclusions: Serum levels of VAP-1 are associated with the severity of kidney damage or stages of kidney disease. The true mechanism which links the serum VAP-1 and CKD remains to be elucidated in further studies.

KW - Amine oxidase

KW - Chronic kidney disease

KW - Microalbuminuria

KW - SSAO

KW - Vascular adhesion protein-1

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SN - 0009-9120

VL - 41

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EP - 1367

JO - Clinical Biochemistry

JF - Clinical Biochemistry

IS - 16-17

ER -

Serum vascular adhesion protein-1 is higher in subjects with early stages of chronic kidney disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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