Abstract

Background. This study assessed whether serum lipid levels are associated with the risk of symptomatic intracerebral hemorrhage (sICH) and functional outcomes in patients with acute ischemic stroke after receiving intravenous thrombolysis. Methods. We retrospectively analyzed consecutive ischemic stroke patients who were treated with intravenous tissue plasminogen activator between January 2007 and January 2017. Lipid levels on admission, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels, as well as potential predictors of sICH were tested using univariate and multivariate analyses. Results. Of the 229 enrolled patients (100 women, aged 68 ± 13 years), 14 developed sICH and 103 (45%) had favorable functional outcomes at 3 months. The patients with sICH more often had diabetes mellitus (71% vs. 26%, P = 0.01) and had more severe stroke (mean National Institutes of Health Stroke Scale [NIHSS] score of 16 vs. 13, P = 0.045). Regarding lipid subtype, total cholesterol, LDL-C, HDL-C, and triglyceride levels were not associated with sICH or functional outcomes. According to the results of multivariate analysis, the frequency of sICH was independently associated with diabetes mellitus (odds ratio [OR] = 6.04; 95% CI [1.31–27.95]; P = 0.02) and the NIHSS score (OR = 1.12; 95% CI [1.02–1.22]; P = 0.01). A higher NIHSS score was independently associated with unfavorable functional outcomes (OR = 0.86; 95% CI [0.81–0.91]; P < 0.001). Conclusions. Serum lipid levels on admission, including total cholesterol, LDL-C, HDL-C, and triglyceride levels, were not associated with sICH or 3-month functional outcomes after intravenous thrombolysis for acute ischemic stroke.

Original languageEnglish
Article numbere6021
JournalPeerJ
Volume2018
Issue number11
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Cerebral Hemorrhage
stroke
blood lipids
hemorrhage
Cholesterol
Stroke
LDL Cholesterol
HDL Cholesterol
Lipids
National Institutes of Health
Health
Medical problems
Serum
National Institutes of Health (U.S.)
low density lipoprotein cholesterol
high density lipoprotein cholesterol
odds ratio
triacylglycerols
Odds Ratio
cholesterol

Keywords

  • Ischemic stroke
  • Lipid
  • Symptomatic intracerebral hemorrhage
  • Thrombolysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{80e9260a56af41ec9b66b3e648575cb7,
title = "Serum lipid level is not associated with symptomatic intracerebral hemorrhage after intravenous thrombolysis for acute ischemic stroke",
abstract = "Background. This study assessed whether serum lipid levels are associated with the risk of symptomatic intracerebral hemorrhage (sICH) and functional outcomes in patients with acute ischemic stroke after receiving intravenous thrombolysis. Methods. We retrospectively analyzed consecutive ischemic stroke patients who were treated with intravenous tissue plasminogen activator between January 2007 and January 2017. Lipid levels on admission, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels, as well as potential predictors of sICH were tested using univariate and multivariate analyses. Results. Of the 229 enrolled patients (100 women, aged 68 ± 13 years), 14 developed sICH and 103 (45{\%}) had favorable functional outcomes at 3 months. The patients with sICH more often had diabetes mellitus (71{\%} vs. 26{\%}, P = 0.01) and had more severe stroke (mean National Institutes of Health Stroke Scale [NIHSS] score of 16 vs. 13, P = 0.045). Regarding lipid subtype, total cholesterol, LDL-C, HDL-C, and triglyceride levels were not associated with sICH or functional outcomes. According to the results of multivariate analysis, the frequency of sICH was independently associated with diabetes mellitus (odds ratio [OR] = 6.04; 95{\%} CI [1.31–27.95]; P = 0.02) and the NIHSS score (OR = 1.12; 95{\%} CI [1.02–1.22]; P = 0.01). A higher NIHSS score was independently associated with unfavorable functional outcomes (OR = 0.86; 95{\%} CI [0.81–0.91]; P < 0.001). Conclusions. Serum lipid levels on admission, including total cholesterol, LDL-C, HDL-C, and triglyceride levels, were not associated with sICH or 3-month functional outcomes after intravenous thrombolysis for acute ischemic stroke.",
keywords = "Ischemic stroke, Lipid, Symptomatic intracerebral hemorrhage, Thrombolysis, Ischemic stroke, Lipid, Symptomatic intracerebral hemorrhage, Thrombolysis",
author = "Lin, {Ting Chun} and Lin, {Yen Kuang} and Chen, {Chin I.} and Lung Chan and Chi, {Nai Fang} and Yuan, {Rey Yue} and Sheu, {Jau Jiuan} and Wei, {Chun Ren} and Tsai, {Jui Ping} and Yeh, {Tu Hsueh}",
year = "2018",
month = "1",
day = "1",
doi = "10.7717/peerj.6021",
language = "English",
volume = "2018",
journal = "PeerJ",
issn = "2167-8359",
publisher = "PeerJ Inc.",
number = "11",

}

TY - JOUR

T1 - Serum lipid level is not associated with symptomatic intracerebral hemorrhage after intravenous thrombolysis for acute ischemic stroke

AU - Lin, Ting Chun

AU - Lin, Yen Kuang

AU - Chen, Chin I.

AU - Chan, Lung

AU - Chi, Nai Fang

AU - Yuan, Rey Yue

AU - Sheu, Jau Jiuan

AU - Wei, Chun Ren

AU - Tsai, Jui Ping

AU - Yeh, Tu Hsueh

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background. This study assessed whether serum lipid levels are associated with the risk of symptomatic intracerebral hemorrhage (sICH) and functional outcomes in patients with acute ischemic stroke after receiving intravenous thrombolysis. Methods. We retrospectively analyzed consecutive ischemic stroke patients who were treated with intravenous tissue plasminogen activator between January 2007 and January 2017. Lipid levels on admission, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels, as well as potential predictors of sICH were tested using univariate and multivariate analyses. Results. Of the 229 enrolled patients (100 women, aged 68 ± 13 years), 14 developed sICH and 103 (45%) had favorable functional outcomes at 3 months. The patients with sICH more often had diabetes mellitus (71% vs. 26%, P = 0.01) and had more severe stroke (mean National Institutes of Health Stroke Scale [NIHSS] score of 16 vs. 13, P = 0.045). Regarding lipid subtype, total cholesterol, LDL-C, HDL-C, and triglyceride levels were not associated with sICH or functional outcomes. According to the results of multivariate analysis, the frequency of sICH was independently associated with diabetes mellitus (odds ratio [OR] = 6.04; 95% CI [1.31–27.95]; P = 0.02) and the NIHSS score (OR = 1.12; 95% CI [1.02–1.22]; P = 0.01). A higher NIHSS score was independently associated with unfavorable functional outcomes (OR = 0.86; 95% CI [0.81–0.91]; P < 0.001). Conclusions. Serum lipid levels on admission, including total cholesterol, LDL-C, HDL-C, and triglyceride levels, were not associated with sICH or 3-month functional outcomes after intravenous thrombolysis for acute ischemic stroke.

AB - Background. This study assessed whether serum lipid levels are associated with the risk of symptomatic intracerebral hemorrhage (sICH) and functional outcomes in patients with acute ischemic stroke after receiving intravenous thrombolysis. Methods. We retrospectively analyzed consecutive ischemic stroke patients who were treated with intravenous tissue plasminogen activator between January 2007 and January 2017. Lipid levels on admission, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride levels, as well as potential predictors of sICH were tested using univariate and multivariate analyses. Results. Of the 229 enrolled patients (100 women, aged 68 ± 13 years), 14 developed sICH and 103 (45%) had favorable functional outcomes at 3 months. The patients with sICH more often had diabetes mellitus (71% vs. 26%, P = 0.01) and had more severe stroke (mean National Institutes of Health Stroke Scale [NIHSS] score of 16 vs. 13, P = 0.045). Regarding lipid subtype, total cholesterol, LDL-C, HDL-C, and triglyceride levels were not associated with sICH or functional outcomes. According to the results of multivariate analysis, the frequency of sICH was independently associated with diabetes mellitus (odds ratio [OR] = 6.04; 95% CI [1.31–27.95]; P = 0.02) and the NIHSS score (OR = 1.12; 95% CI [1.02–1.22]; P = 0.01). A higher NIHSS score was independently associated with unfavorable functional outcomes (OR = 0.86; 95% CI [0.81–0.91]; P < 0.001). Conclusions. Serum lipid levels on admission, including total cholesterol, LDL-C, HDL-C, and triglyceride levels, were not associated with sICH or 3-month functional outcomes after intravenous thrombolysis for acute ischemic stroke.

KW - Ischemic stroke

KW - Lipid

KW - Symptomatic intracerebral hemorrhage

KW - Thrombolysis

KW - Ischemic stroke

KW - Lipid

KW - Symptomatic intracerebral hemorrhage

KW - Thrombolysis

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U2 - 10.7717/peerj.6021

DO - 10.7717/peerj.6021

M3 - Article

AN - SCOPUS:85057768042

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JO - PeerJ

JF - PeerJ

SN - 2167-8359

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