Serum levels of intercellular adhesion molecule-1 and E-selectin in patients with acute ischaemic stroke

Kou G. Shyu, Hang Chang, Cheng Chung Lin

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

To investigate the role of circulating intercellular adhesion molecule-1 (ICAM-1) and E-selectin in ischaemic stroke, serum levels of ICAM-1 and E-selectin were measured by ELISA in 51 patients with acute ischaemic stroke within 24 h, and in 25 age-matched healthy controls and 10 young healthy volunteers. Carotid Doppler ultrasonography showed a significant stenosis (> 50%) of the carotid or vertebrobasilar artery in 11 of 51 stroke patients. Serum levels of ICAM-1 [mean (SE)I were higher (P <0.01) in patients with ischaemic stroke [381 (30) ng/ml] than in age-matched controls [271 (27) ng/ml] and young controls [246 (6) ng/ml]. There was no significant difference in serum E-selectin levels [mean (SE)] among stroke patients, age-matched and young controls [47 (6), 39 (3), and 41 (3) ng/ml, respectively; P = NS]. The leucocyte count [mean (SD)] was higher (P <0.01) in patients with ischaemic stroke [8310 (2800)] than in age-matched controls [6040 (930)]. Serum levels of ICAM-1 and E-selectin did not significantly differ between patients with or without abnormal carotid or vertebrobasilar artery disease. In conclusion, serum ICAM-1 level and leucocyte count were elevated in acute ischaemic stroke within 24 h, while the E-selectin level did not change significantly. This finding suggests that adhesion molecules may play an important role in the post-rolling process of leucocyte-endothelial cell interaction in acute ischaemic stroke.

Original languageEnglish
Pages (from-to)90-93
Number of pages4
JournalJournal of Neurology
Volume244
Issue number2
DOIs
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

E-Selectin
Intercellular Adhesion Molecule-1
Stroke
Serum
Leukocyte Count
Arteries
Leukocyte Rolling
Doppler Ultrasonography
Cell Communication
Healthy Volunteers
Pathologic Constriction
Endothelial Cells
Enzyme-Linked Immunosorbent Assay

Keywords

  • E-selectin
  • Intercellular adhesion molecule-1
  • Ischaemic stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Serum levels of intercellular adhesion molecule-1 and E-selectin in patients with acute ischaemic stroke. / Shyu, Kou G.; Chang, Hang; Lin, Cheng Chung.

In: Journal of Neurology, Vol. 244, No. 2, 1997, p. 90-93.

Research output: Contribution to journalArticle

Shyu, Kou G. ; Chang, Hang ; Lin, Cheng Chung. / Serum levels of intercellular adhesion molecule-1 and E-selectin in patients with acute ischaemic stroke. In: Journal of Neurology. 1997 ; Vol. 244, No. 2. pp. 90-93.
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