Abstract

Dysregulated iron metabolism is associated with altered body composition and nonalcoholic fatty liver disease (NAFLD); however, mechanisms underlying this association remain undefined. We investigated this association in 117 women. Middle-aged women (≥45 years old (y)) were heavier and had lower serum iron, higher serum hepcidin, ferritin, and severe NAFLD incidence than young adult women (<45 y). Age-adjusted linear regression analysis revealed that young adult women with the highest serum iron:ferritin ratio (Tertile 3) had a 5.08-unit increased percentage of muscle mass [β = 5.08 (1.48–8.68), p < 0.001] and a 1.21-unit decreased percentage visceral fat mass [β = −1.21 (−2.03 to −0.39), p < 0.001] compared with those with the lowest serum iron:ferritin ratio (Tertile 1; reference). The iron:ferritin dietary pattern, characterized by high consumption of beef, lamb, dairy products, fruits, and whole grains, and low consumption of refined carbohydrates (rice, noodles, and bread and pastries), and deep- and stir-fried foods, predicted a 90% [odds ratio: 0.10, 95% confidence interval: 0.02–0.47, p < 0.001] reduced risk of mild vs. moderate and severe NAFLD in young adult women. Our findings suggest that the serum iron:ferritin ratio more accurately predicts body composition and reduced risk of severe fatty liver progression in young adult women compared to middle-aged women.

Original languageEnglish
Article number833
JournalNutrients
Volume9
Issue number8
DOIs
Publication statusPublished - Aug 4 2017

Fingerprint

fatty liver
ferritin
Fatty Liver
Ferritins
Body Composition
young adults
body composition
Young Adult
Iron
iron
Serum
middle-aged adults
Dietary Iron
Hepcidins
fried foods
pastries
visceral fat
noodles
Dairy Products
Intra-Abdominal Fat

Keywords

  • Body composition
  • Dietary pattern
  • Non-alcoholic fatty liver disease
  • Serum ferritin
  • Serum iron

ASJC Scopus subject areas

  • Food Science

Cite this

@article{a6f211d70d5341dd916db6d708db0145,
title = "Serum iron: Ferritin ratio predicts healthy body composition and reduced risk of severe fatty liver in young adult women",
abstract = "Dysregulated iron metabolism is associated with altered body composition and nonalcoholic fatty liver disease (NAFLD); however, mechanisms underlying this association remain undefined. We investigated this association in 117 women. Middle-aged women (≥45 years old (y)) were heavier and had lower serum iron, higher serum hepcidin, ferritin, and severe NAFLD incidence than young adult women (<45 y). Age-adjusted linear regression analysis revealed that young adult women with the highest serum iron:ferritin ratio (Tertile 3) had a 5.08-unit increased percentage of muscle mass [β = 5.08 (1.48–8.68), p < 0.001] and a 1.21-unit decreased percentage visceral fat mass [β = −1.21 (−2.03 to −0.39), p < 0.001] compared with those with the lowest serum iron:ferritin ratio (Tertile 1; reference). The iron:ferritin dietary pattern, characterized by high consumption of beef, lamb, dairy products, fruits, and whole grains, and low consumption of refined carbohydrates (rice, noodles, and bread and pastries), and deep- and stir-fried foods, predicted a 90{\%} [odds ratio: 0.10, 95{\%} confidence interval: 0.02–0.47, p < 0.001] reduced risk of mild vs. moderate and severe NAFLD in young adult women. Our findings suggest that the serum iron:ferritin ratio more accurately predicts body composition and reduced risk of severe fatty liver progression in young adult women compared to middle-aged women.",
keywords = "Body composition, Dietary pattern, Non-alcoholic fatty liver disease, Serum ferritin, Serum iron",
author = "Nindy Sabrina and Bai, {Chyi Huey} and Chang, {Chun Chao} and Chien, {Yi Wen} and Chen, {Jiun Rong} and Chang, {Jung Su}",
year = "2017",
month = "8",
day = "4",
doi = "10.3390/nu9080833",
language = "English",
volume = "9",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "8",

}

TY - JOUR

T1 - Serum iron

T2 - Ferritin ratio predicts healthy body composition and reduced risk of severe fatty liver in young adult women

AU - Sabrina, Nindy

AU - Bai, Chyi Huey

AU - Chang, Chun Chao

AU - Chien, Yi Wen

AU - Chen, Jiun Rong

AU - Chang, Jung Su

PY - 2017/8/4

Y1 - 2017/8/4

N2 - Dysregulated iron metabolism is associated with altered body composition and nonalcoholic fatty liver disease (NAFLD); however, mechanisms underlying this association remain undefined. We investigated this association in 117 women. Middle-aged women (≥45 years old (y)) were heavier and had lower serum iron, higher serum hepcidin, ferritin, and severe NAFLD incidence than young adult women (<45 y). Age-adjusted linear regression analysis revealed that young adult women with the highest serum iron:ferritin ratio (Tertile 3) had a 5.08-unit increased percentage of muscle mass [β = 5.08 (1.48–8.68), p < 0.001] and a 1.21-unit decreased percentage visceral fat mass [β = −1.21 (−2.03 to −0.39), p < 0.001] compared with those with the lowest serum iron:ferritin ratio (Tertile 1; reference). The iron:ferritin dietary pattern, characterized by high consumption of beef, lamb, dairy products, fruits, and whole grains, and low consumption of refined carbohydrates (rice, noodles, and bread and pastries), and deep- and stir-fried foods, predicted a 90% [odds ratio: 0.10, 95% confidence interval: 0.02–0.47, p < 0.001] reduced risk of mild vs. moderate and severe NAFLD in young adult women. Our findings suggest that the serum iron:ferritin ratio more accurately predicts body composition and reduced risk of severe fatty liver progression in young adult women compared to middle-aged women.

AB - Dysregulated iron metabolism is associated with altered body composition and nonalcoholic fatty liver disease (NAFLD); however, mechanisms underlying this association remain undefined. We investigated this association in 117 women. Middle-aged women (≥45 years old (y)) were heavier and had lower serum iron, higher serum hepcidin, ferritin, and severe NAFLD incidence than young adult women (<45 y). Age-adjusted linear regression analysis revealed that young adult women with the highest serum iron:ferritin ratio (Tertile 3) had a 5.08-unit increased percentage of muscle mass [β = 5.08 (1.48–8.68), p < 0.001] and a 1.21-unit decreased percentage visceral fat mass [β = −1.21 (−2.03 to −0.39), p < 0.001] compared with those with the lowest serum iron:ferritin ratio (Tertile 1; reference). The iron:ferritin dietary pattern, characterized by high consumption of beef, lamb, dairy products, fruits, and whole grains, and low consumption of refined carbohydrates (rice, noodles, and bread and pastries), and deep- and stir-fried foods, predicted a 90% [odds ratio: 0.10, 95% confidence interval: 0.02–0.47, p < 0.001] reduced risk of mild vs. moderate and severe NAFLD in young adult women. Our findings suggest that the serum iron:ferritin ratio more accurately predicts body composition and reduced risk of severe fatty liver progression in young adult women compared to middle-aged women.

KW - Body composition

KW - Dietary pattern

KW - Non-alcoholic fatty liver disease

KW - Serum ferritin

KW - Serum iron

UR - http://www.scopus.com/inward/record.url?scp=85026923223&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85026923223&partnerID=8YFLogxK

U2 - 10.3390/nu9080833

DO - 10.3390/nu9080833

M3 - Article

C2 - 28777296

AN - SCOPUS:85026923223

VL - 9

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 8

M1 - 833

ER -