Serum Homocysteine, Folate, and Vitamin B12 Levels in Patients with Systemic Lupus Erythematosus: A Meta-Analysis and Meta-Regression

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Patients with systemic lupus erythematosus (SLE) have elevated cardiovascular risk. Hyperhomocysteinemia may be one of the contributing factors to this phenomenon. This study therefore aimed to compare the serum homocysteine levels and the levels of folate and vitamin B12, cofactors for homocysteine metabolism, between individuals with and without SLE. Methods: A literature search was performed in PubMed, Embase, and the Cochrane library (from inception to March 31, 2019). Studies comparing serum homocysteine, folate or vitamin B12 levels between individuals with and without SLE were selected. Of the 1040 screened studies, 50 studies met the inclusion criteria. Results: A total of 50 studies involving 4396 patients with SLE were included. Patients with SLE had a significantly higher serum level of homocysteine (standardized mean difference [SMD], 1.134; 95% CI, 0.795–1.474) and lower level of vitamin B12 (SMD, −0.359; 95% CI, −0.638 to −0.080) than controls. The folate level didn’t differ markedly between SLE patients and the control group (SMD, −0.276; 95% CI, −0.674–0.123). Subgroup analysis showed consistent results in adult SLE patients. A random effects meta-regression analysis revealed a significantly inverse correlation between the SMD of homocysteine levels and C3 levels (coefficient, −0.0356, 95% CI, −0.054 to −0.0171; P <.001) and C4 levels (coefficient, −0.0876, 95% CI, −0.1407 to −0.0345; P =.0012). Conclusions: Serum homocysteine levels were higher and vitamin B12 levels were lower among individuals with SLE than those without SLE. Physicians are encouraged to monitor these parameters and offer timely interventions for patients with SLE.

Original languageEnglish
Pages (from-to)443-453
Number of pages11
JournalJournal of the American College of Nutrition
Volume40
Issue number5
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • cardiovascular disease
  • folate
  • Homocysteine
  • systemic lupus erythematosus
  • vitamin B12

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint

Dive into the research topics of 'Serum Homocysteine, Folate, and Vitamin B<sub>12</sub> Levels in Patients with Systemic Lupus Erythematosus: A Meta-Analysis and Meta-Regression'. Together they form a unique fingerprint.

Cite this