Serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis

Tsung Yu Tsai, Che Yuan Kuo, Yu-Chen Huang

Research output: Contribution to journalArticle

Abstract

Background: Hyperhomocysteinemia and folate and vitamin B12 deficiencies have been reported in patients with vitiligo. Investigating the role of these conditions might shed light on the pathogenesis of vitiligo. Objective: To perform a systematic review and meta-analysis of studies assessing serum homocysteine, folate, and vitamin B12 levels in vitiligo patients. Methods: Online databases were searched on May 15, 2018, to identify studies comparing serum homocysteine, folate, and vitamin B12 levels between patients with vitiligo and controls. A random effects model was used. Results: Twenty-two studies involving a total of 1448 patients with vitiligo were included. Patients with vitiligo had significantly higher serum homocysteine levels (standardized mean difference [SMD] 0.550, 95% confidence interval [CI] 0.262-0.838; I2 87.3%) and lower vitamin B12 levels (SMD −0.430, 95% CI −0.738 to −0.121; I2 85.3%) than controls. Serum folate levels were not significantly different between the 2 groups (SMD –0.240, 95% CI –0.592 to 0.111; I2 85.5%). A subgroup analysis revealed that these findings correlated with disease activity. Limitations: The included studies were heterogeneous. Serum homocysteine levels could be influenced by various factors. Conclusion: Patients with vitiligo have higher serum homocysteine levels and lower vitamin B12 levels than individuals without vitiligo.

Original languageEnglish
JournalJournal of the American Academy of Dermatology
DOIs
Publication statusAccepted/In press - Jan 1 2018

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Vitiligo
Homocysteine
Vitamin B 12
Folic Acid
Meta-Analysis
Biomarkers
Serum
Confidence Intervals
Vitamin B 12 Deficiency
Hyperhomocysteinemia
Databases

Keywords

  • folate
  • homocysteine
  • hyperhomocysteinemia
  • vitamin B
  • vitiligo

ASJC Scopus subject areas

  • Dermatology

Cite this

@article{c5172a4e1ef84c8888832a4474f937f2,
title = "Serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis",
abstract = "Background: Hyperhomocysteinemia and folate and vitamin B12 deficiencies have been reported in patients with vitiligo. Investigating the role of these conditions might shed light on the pathogenesis of vitiligo. Objective: To perform a systematic review and meta-analysis of studies assessing serum homocysteine, folate, and vitamin B12 levels in vitiligo patients. Methods: Online databases were searched on May 15, 2018, to identify studies comparing serum homocysteine, folate, and vitamin B12 levels between patients with vitiligo and controls. A random effects model was used. Results: Twenty-two studies involving a total of 1448 patients with vitiligo were included. Patients with vitiligo had significantly higher serum homocysteine levels (standardized mean difference [SMD] 0.550, 95{\%} confidence interval [CI] 0.262-0.838; I2 87.3{\%}) and lower vitamin B12 levels (SMD −0.430, 95{\%} CI −0.738 to −0.121; I2 85.3{\%}) than controls. Serum folate levels were not significantly different between the 2 groups (SMD –0.240, 95{\%} CI –0.592 to 0.111; I2 85.5{\%}). A subgroup analysis revealed that these findings correlated with disease activity. Limitations: The included studies were heterogeneous. Serum homocysteine levels could be influenced by various factors. Conclusion: Patients with vitiligo have higher serum homocysteine levels and lower vitamin B12 levels than individuals without vitiligo.",
keywords = "folate, homocysteine, hyperhomocysteinemia, vitamin B, vitiligo",
author = "Tsai, {Tsung Yu} and Kuo, {Che Yuan} and Yu-Chen Huang",
year = "2018",
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doi = "10.1016/j.jaad.2018.08.029",
language = "English",
journal = "Journal of the American Academy of Dermatology",
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T1 - Serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo and their potential roles as disease activity biomarkers

T2 - A systematic review and meta-analysis

AU - Tsai, Tsung Yu

AU - Kuo, Che Yuan

AU - Huang, Yu-Chen

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Hyperhomocysteinemia and folate and vitamin B12 deficiencies have been reported in patients with vitiligo. Investigating the role of these conditions might shed light on the pathogenesis of vitiligo. Objective: To perform a systematic review and meta-analysis of studies assessing serum homocysteine, folate, and vitamin B12 levels in vitiligo patients. Methods: Online databases were searched on May 15, 2018, to identify studies comparing serum homocysteine, folate, and vitamin B12 levels between patients with vitiligo and controls. A random effects model was used. Results: Twenty-two studies involving a total of 1448 patients with vitiligo were included. Patients with vitiligo had significantly higher serum homocysteine levels (standardized mean difference [SMD] 0.550, 95% confidence interval [CI] 0.262-0.838; I2 87.3%) and lower vitamin B12 levels (SMD −0.430, 95% CI −0.738 to −0.121; I2 85.3%) than controls. Serum folate levels were not significantly different between the 2 groups (SMD –0.240, 95% CI –0.592 to 0.111; I2 85.5%). A subgroup analysis revealed that these findings correlated with disease activity. Limitations: The included studies were heterogeneous. Serum homocysteine levels could be influenced by various factors. Conclusion: Patients with vitiligo have higher serum homocysteine levels and lower vitamin B12 levels than individuals without vitiligo.

AB - Background: Hyperhomocysteinemia and folate and vitamin B12 deficiencies have been reported in patients with vitiligo. Investigating the role of these conditions might shed light on the pathogenesis of vitiligo. Objective: To perform a systematic review and meta-analysis of studies assessing serum homocysteine, folate, and vitamin B12 levels in vitiligo patients. Methods: Online databases were searched on May 15, 2018, to identify studies comparing serum homocysteine, folate, and vitamin B12 levels between patients with vitiligo and controls. A random effects model was used. Results: Twenty-two studies involving a total of 1448 patients with vitiligo were included. Patients with vitiligo had significantly higher serum homocysteine levels (standardized mean difference [SMD] 0.550, 95% confidence interval [CI] 0.262-0.838; I2 87.3%) and lower vitamin B12 levels (SMD −0.430, 95% CI −0.738 to −0.121; I2 85.3%) than controls. Serum folate levels were not significantly different between the 2 groups (SMD –0.240, 95% CI –0.592 to 0.111; I2 85.5%). A subgroup analysis revealed that these findings correlated with disease activity. Limitations: The included studies were heterogeneous. Serum homocysteine levels could be influenced by various factors. Conclusion: Patients with vitiligo have higher serum homocysteine levels and lower vitamin B12 levels than individuals without vitiligo.

KW - folate

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