TY - JOUR
T1 - Serum glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) levels in children and adolescents with intellectual disabilities
AU - Lin, Jin Ding
AU - Lin, Pei Ying
AU - Chen, Li Mei
AU - Fang, Wen Hui
AU - Lin, Lan Ping
AU - Loh, Ching Hui
N1 - Funding Information:
This research was financially supported by Bureau of Health Promotion, Department of Health, Executive Yuan, Republic of China (Taiwan) (DOH97-HP-1601). We would also like to thank the school's staffs who support this study.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - The elevated serum glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) rate among people with intellectual disabilities (ID) is unknown and have not been sufficiently studies. The present paper aims to provide the profile of GOT and GPT, and their associated relationship with other biochemical levels of children or adolescents with ID. A cross-sectional design was conducted in three Taiwanese public special schools to analyze annual health examination chart of students with ID. There were 1041 aged 3-21 years children and adolescents with ID participated in the study. The results show elevated rate of GOT and GPT were 3.7% and 7.2%, the study indicates the elevated GPT in children and adolescents with ID is higher than the general school aged children in Taiwan. In multiple linear regression models show that the factors of BMI, HBsAg, TC and UA can significantly explain the GOT value (R2 = 0.275). Those factors of gender, BMI, HBsAg, TC and UA can significantly explain 44.4% variation of GPT value (R2 = 0.444). To prevent the further liver disease burden in people with ID, the study highlights that the health care professionals should assess liver functions of this group of people, and to inform their caregivers the importance of implement regular liver health check-up.
AB - The elevated serum glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) rate among people with intellectual disabilities (ID) is unknown and have not been sufficiently studies. The present paper aims to provide the profile of GOT and GPT, and their associated relationship with other biochemical levels of children or adolescents with ID. A cross-sectional design was conducted in three Taiwanese public special schools to analyze annual health examination chart of students with ID. There were 1041 aged 3-21 years children and adolescents with ID participated in the study. The results show elevated rate of GOT and GPT were 3.7% and 7.2%, the study indicates the elevated GPT in children and adolescents with ID is higher than the general school aged children in Taiwan. In multiple linear regression models show that the factors of BMI, HBsAg, TC and UA can significantly explain the GOT value (R2 = 0.275). Those factors of gender, BMI, HBsAg, TC and UA can significantly explain 44.4% variation of GPT value (R2 = 0.444). To prevent the further liver disease burden in people with ID, the study highlights that the health care professionals should assess liver functions of this group of people, and to inform their caregivers the importance of implement regular liver health check-up.
KW - Glutamic-oxaloacetic transaminase (GOT)
KW - Glutamic-pyruvic transaminase (GPT)
KW - Intellectual disability
KW - Liver function
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UR - http://www.scopus.com/inward/citedby.url?scp=70350741206&partnerID=8YFLogxK
U2 - 10.1016/j.ridd.2009.08.005
DO - 10.1016/j.ridd.2009.08.005
M3 - Article
C2 - 19828286
AN - SCOPUS:70350741206
VL - 31
SP - 172
EP - 177
JO - Applied Research in Mental Retardation
JF - Applied Research in Mental Retardation
SN - 0891-4222
IS - 1
ER -