Serum fetuin-A concentrations are elevated in subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes

Horng Yih Ou, Yi Ching Yang, Hung Tsung Wu, Jin Shang Wu, Feng Hwa Lu, Chih Jen Chang

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Objective Hepatic steatosis is associated with an increased risk of diabetes. Although the levels of serum fetuin-A, a liver-derived glycoprotein that impairs insulin signalling, are positively correlated with hepatic steatosis, the levels of fetuin-A in subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and newly diagnosed type 2 diabetes (NDD) have not been established. The aim of this study is to investigate the relationship among serum fetuin-A concentrations, IFG, IGT and NDD in Chinese subjects without nonalcoholic fatty liver disease (NAFLD). Design A total of 360 age- and sex-matched subjects with normal glucose tolerance (NGT), IFG, IGT and NDD were recruited in this case-control study. Measurements Each subject was assessed by abdominal ultrasound to exclude the presence of NAFLD. Serum fetuin-A concentrations were measured by enzyme-linked immunosorbent assay and compared between NGT, IFG, IGT and NDD groups. The association with clinical and metabolic parameters was also examined. Results Serum fetuin-A concentrations were higher in NDD and IGT groups than NGT groups (341 ± 88, 335 ± 90, and 300 ± 75 μg/ml). In multiple linear regression analysis, IGT (P < 0 ·01) and NDD (P < 0 ·05) were the positively associated factors of serum fetuin-A concentrations, but age (P < 0 ·05) was a negatively associated factor after adjusting for age, anthropometric indices, lipid profile, estimated glomerular filtration rate (eGFR), adiponectin, C-reactive protein (CRP) and homeostasis model assessment (HOMA-IR). Conclusions IGT and NDD are positively associated with serum fetuin-A concentrations in subjects without NAFLD independent of cardiometabolic risk factors.

Original languageEnglish
Pages (from-to)450-455
Number of pages6
JournalClinical Endocrinology
Volume75
Issue number4
DOIs
Publication statusPublished - Oct 1 2011
Externally publishedYes

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alpha-2-HS-Glycoprotein
Glucose Intolerance
Type 2 Diabetes Mellitus
Serum
Fasting
Glucose
Liver
Adiponectin
Glomerular Filtration Rate
C-Reactive Protein
Case-Control Studies
Linear Models
Glycoproteins
Homeostasis
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Insulin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Serum fetuin-A concentrations are elevated in subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes. / Ou, Horng Yih; Yang, Yi Ching; Wu, Hung Tsung; Wu, Jin Shang; Lu, Feng Hwa; Chang, Chih Jen.

In: Clinical Endocrinology, Vol. 75, No. 4, 01.10.2011, p. 450-455.

Research output: Contribution to journalArticle

Ou, Horng Yih ; Yang, Yi Ching ; Wu, Hung Tsung ; Wu, Jin Shang ; Lu, Feng Hwa ; Chang, Chih Jen. / Serum fetuin-A concentrations are elevated in subjects with impaired glucose tolerance and newly diagnosed type 2 diabetes. In: Clinical Endocrinology. 2011 ; Vol. 75, No. 4. pp. 450-455.
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abstract = "Objective Hepatic steatosis is associated with an increased risk of diabetes. Although the levels of serum fetuin-A, a liver-derived glycoprotein that impairs insulin signalling, are positively correlated with hepatic steatosis, the levels of fetuin-A in subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and newly diagnosed type 2 diabetes (NDD) have not been established. The aim of this study is to investigate the relationship among serum fetuin-A concentrations, IFG, IGT and NDD in Chinese subjects without nonalcoholic fatty liver disease (NAFLD). Design A total of 360 age- and sex-matched subjects with normal glucose tolerance (NGT), IFG, IGT and NDD were recruited in this case-control study. Measurements Each subject was assessed by abdominal ultrasound to exclude the presence of NAFLD. Serum fetuin-A concentrations were measured by enzyme-linked immunosorbent assay and compared between NGT, IFG, IGT and NDD groups. The association with clinical and metabolic parameters was also examined. Results Serum fetuin-A concentrations were higher in NDD and IGT groups than NGT groups (341 ± 88, 335 ± 90, and 300 ± 75 μg/ml). In multiple linear regression analysis, IGT (P < 0 ·01) and NDD (P < 0 ·05) were the positively associated factors of serum fetuin-A concentrations, but age (P < 0 ·05) was a negatively associated factor after adjusting for age, anthropometric indices, lipid profile, estimated glomerular filtration rate (eGFR), adiponectin, C-reactive protein (CRP) and homeostasis model assessment (HOMA-IR). Conclusions IGT and NDD are positively associated with serum fetuin-A concentrations in subjects without NAFLD independent of cardiometabolic risk factors.",
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N2 - Objective Hepatic steatosis is associated with an increased risk of diabetes. Although the levels of serum fetuin-A, a liver-derived glycoprotein that impairs insulin signalling, are positively correlated with hepatic steatosis, the levels of fetuin-A in subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and newly diagnosed type 2 diabetes (NDD) have not been established. The aim of this study is to investigate the relationship among serum fetuin-A concentrations, IFG, IGT and NDD in Chinese subjects without nonalcoholic fatty liver disease (NAFLD). Design A total of 360 age- and sex-matched subjects with normal glucose tolerance (NGT), IFG, IGT and NDD were recruited in this case-control study. Measurements Each subject was assessed by abdominal ultrasound to exclude the presence of NAFLD. Serum fetuin-A concentrations were measured by enzyme-linked immunosorbent assay and compared between NGT, IFG, IGT and NDD groups. The association with clinical and metabolic parameters was also examined. Results Serum fetuin-A concentrations were higher in NDD and IGT groups than NGT groups (341 ± 88, 335 ± 90, and 300 ± 75 μg/ml). In multiple linear regression analysis, IGT (P < 0 ·01) and NDD (P < 0 ·05) were the positively associated factors of serum fetuin-A concentrations, but age (P < 0 ·05) was a negatively associated factor after adjusting for age, anthropometric indices, lipid profile, estimated glomerular filtration rate (eGFR), adiponectin, C-reactive protein (CRP) and homeostasis model assessment (HOMA-IR). Conclusions IGT and NDD are positively associated with serum fetuin-A concentrations in subjects without NAFLD independent of cardiometabolic risk factors.

AB - Objective Hepatic steatosis is associated with an increased risk of diabetes. Although the levels of serum fetuin-A, a liver-derived glycoprotein that impairs insulin signalling, are positively correlated with hepatic steatosis, the levels of fetuin-A in subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and newly diagnosed type 2 diabetes (NDD) have not been established. The aim of this study is to investigate the relationship among serum fetuin-A concentrations, IFG, IGT and NDD in Chinese subjects without nonalcoholic fatty liver disease (NAFLD). Design A total of 360 age- and sex-matched subjects with normal glucose tolerance (NGT), IFG, IGT and NDD were recruited in this case-control study. Measurements Each subject was assessed by abdominal ultrasound to exclude the presence of NAFLD. Serum fetuin-A concentrations were measured by enzyme-linked immunosorbent assay and compared between NGT, IFG, IGT and NDD groups. The association with clinical and metabolic parameters was also examined. Results Serum fetuin-A concentrations were higher in NDD and IGT groups than NGT groups (341 ± 88, 335 ± 90, and 300 ± 75 μg/ml). In multiple linear regression analysis, IGT (P < 0 ·01) and NDD (P < 0 ·05) were the positively associated factors of serum fetuin-A concentrations, but age (P < 0 ·05) was a negatively associated factor after adjusting for age, anthropometric indices, lipid profile, estimated glomerular filtration rate (eGFR), adiponectin, C-reactive protein (CRP) and homeostasis model assessment (HOMA-IR). Conclusions IGT and NDD are positively associated with serum fetuin-A concentrations in subjects without NAFLD independent of cardiometabolic risk factors.

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