Serum ferritin contributes to racial or geographic disparities in metabolic syndrome in Taiwan

Jung Su Chang, Shiue Ming Lin, Jane C J Chao, Yi Chun Chen, Chi Mei Wang, Ni Hsin Chou, Wen Harn Pan, Chyi Huey Bai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives Asians and Pacific Islanders have higher circulating serum ferritin (SF) compared with Caucasians but the clinical significance of this is unclear. There is a higher prevalence of metabolic syndrome (MetS) in Taiwanese Indigenous than Han Chinese. Genetically, Indigenous are related to Austronesians and account for 2 % of Taiwan's population. We tested the hypothesis that accumulation of Fe in the body contributes to the ethnic/racial disparities in MetS in Taiwan. Design A population-based, cross-sectional study. Setting National Nutrition and Health Survey in Taiwan and Penghu Island. Subjects A total of 2638 healthy adults aged ≥19 years. Three ethnic groups were included. Results Han Chinese and Indigenous people had comparable levels of SF. Austronesia origin was independently associated with MetS (OR = 2·61, 95 % CI 2·02, 3·36). After multiple adjustments, the odds for MetS (OR = 2·49, 95 % CI 1·15, 5·28) was significantly higher among Indigenous people in the highest SF tertile compared with those in the lowest tertile. Hakka and Penghu Islanders yielded the lowest risks (OR = 1·08, 95 % CI 0·44, 2·65 and OR = 1·21, 95 % CI 0·52, 2·78, respectively). Indigenous people in the highest SF tertile had increased risk for abnormal levels of fasting glucose (OR = 2·34, 95 % CI 1·27, 4·29), TAG (OR = 1·94, 95 % CI 1·11, 3·39) and HDL-cholesterol (OR = 2·10, 95 % CI 1·18, 3·73) than those in the lowest SF tertile. Conclusions Our results raise the possibility that ethnic/racial differences in body Fe store susceptibility may contribute to racial and geographic disparities in MetS.

Original languageEnglish
Pages (from-to)1498-1506
Number of pages9
JournalPublic Health Nutrition
Volume17
Issue number7
DOIs
Publication statusPublished - 2014

Fingerprint

Ferritins
Taiwan
Serum
Social Adjustment
Nutrition Surveys
Health Surveys
Ethnic Groups
Islands
HDL Cholesterol
Population
Fasting
Cross-Sectional Studies
Glucose

Keywords

  • Ethnicity
  • Metabolic syndrome
  • Odds ratio
  • Serum ferritin
  • Taiwanese Indigenous

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

Serum ferritin contributes to racial or geographic disparities in metabolic syndrome in Taiwan. / Chang, Jung Su; Lin, Shiue Ming; Chao, Jane C J; Chen, Yi Chun; Wang, Chi Mei; Chou, Ni Hsin; Pan, Wen Harn; Bai, Chyi Huey.

In: Public Health Nutrition, Vol. 17, No. 7, 2014, p. 1498-1506.

Research output: Contribution to journalArticle

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abstract = "Objectives Asians and Pacific Islanders have higher circulating serum ferritin (SF) compared with Caucasians but the clinical significance of this is unclear. There is a higher prevalence of metabolic syndrome (MetS) in Taiwanese Indigenous than Han Chinese. Genetically, Indigenous are related to Austronesians and account for 2 {\%} of Taiwan's population. We tested the hypothesis that accumulation of Fe in the body contributes to the ethnic/racial disparities in MetS in Taiwan. Design A population-based, cross-sectional study. Setting National Nutrition and Health Survey in Taiwan and Penghu Island. Subjects A total of 2638 healthy adults aged ≥19 years. Three ethnic groups were included. Results Han Chinese and Indigenous people had comparable levels of SF. Austronesia origin was independently associated with MetS (OR = 2·61, 95 {\%} CI 2·02, 3·36). After multiple adjustments, the odds for MetS (OR = 2·49, 95 {\%} CI 1·15, 5·28) was significantly higher among Indigenous people in the highest SF tertile compared with those in the lowest tertile. Hakka and Penghu Islanders yielded the lowest risks (OR = 1·08, 95 {\%} CI 0·44, 2·65 and OR = 1·21, 95 {\%} CI 0·52, 2·78, respectively). Indigenous people in the highest SF tertile had increased risk for abnormal levels of fasting glucose (OR = 2·34, 95 {\%} CI 1·27, 4·29), TAG (OR = 1·94, 95 {\%} CI 1·11, 3·39) and HDL-cholesterol (OR = 2·10, 95 {\%} CI 1·18, 3·73) than those in the lowest SF tertile. Conclusions Our results raise the possibility that ethnic/racial differences in body Fe store susceptibility may contribute to racial and geographic disparities in MetS.",
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AU - Chang, Jung Su

AU - Lin, Shiue Ming

AU - Chao, Jane C J

AU - Chen, Yi Chun

AU - Wang, Chi Mei

AU - Chou, Ni Hsin

AU - Pan, Wen Harn

AU - Bai, Chyi Huey

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N2 - Objectives Asians and Pacific Islanders have higher circulating serum ferritin (SF) compared with Caucasians but the clinical significance of this is unclear. There is a higher prevalence of metabolic syndrome (MetS) in Taiwanese Indigenous than Han Chinese. Genetically, Indigenous are related to Austronesians and account for 2 % of Taiwan's population. We tested the hypothesis that accumulation of Fe in the body contributes to the ethnic/racial disparities in MetS in Taiwan. Design A population-based, cross-sectional study. Setting National Nutrition and Health Survey in Taiwan and Penghu Island. Subjects A total of 2638 healthy adults aged ≥19 years. Three ethnic groups were included. Results Han Chinese and Indigenous people had comparable levels of SF. Austronesia origin was independently associated with MetS (OR = 2·61, 95 % CI 2·02, 3·36). After multiple adjustments, the odds for MetS (OR = 2·49, 95 % CI 1·15, 5·28) was significantly higher among Indigenous people in the highest SF tertile compared with those in the lowest tertile. Hakka and Penghu Islanders yielded the lowest risks (OR = 1·08, 95 % CI 0·44, 2·65 and OR = 1·21, 95 % CI 0·52, 2·78, respectively). Indigenous people in the highest SF tertile had increased risk for abnormal levels of fasting glucose (OR = 2·34, 95 % CI 1·27, 4·29), TAG (OR = 1·94, 95 % CI 1·11, 3·39) and HDL-cholesterol (OR = 2·10, 95 % CI 1·18, 3·73) than those in the lowest SF tertile. Conclusions Our results raise the possibility that ethnic/racial differences in body Fe store susceptibility may contribute to racial and geographic disparities in MetS.

AB - Objectives Asians and Pacific Islanders have higher circulating serum ferritin (SF) compared with Caucasians but the clinical significance of this is unclear. There is a higher prevalence of metabolic syndrome (MetS) in Taiwanese Indigenous than Han Chinese. Genetically, Indigenous are related to Austronesians and account for 2 % of Taiwan's population. We tested the hypothesis that accumulation of Fe in the body contributes to the ethnic/racial disparities in MetS in Taiwan. Design A population-based, cross-sectional study. Setting National Nutrition and Health Survey in Taiwan and Penghu Island. Subjects A total of 2638 healthy adults aged ≥19 years. Three ethnic groups were included. Results Han Chinese and Indigenous people had comparable levels of SF. Austronesia origin was independently associated with MetS (OR = 2·61, 95 % CI 2·02, 3·36). After multiple adjustments, the odds for MetS (OR = 2·49, 95 % CI 1·15, 5·28) was significantly higher among Indigenous people in the highest SF tertile compared with those in the lowest tertile. Hakka and Penghu Islanders yielded the lowest risks (OR = 1·08, 95 % CI 0·44, 2·65 and OR = 1·21, 95 % CI 0·52, 2·78, respectively). Indigenous people in the highest SF tertile had increased risk for abnormal levels of fasting glucose (OR = 2·34, 95 % CI 1·27, 4·29), TAG (OR = 1·94, 95 % CI 1·11, 3·39) and HDL-cholesterol (OR = 2·10, 95 % CI 1·18, 3·73) than those in the lowest SF tertile. Conclusions Our results raise the possibility that ethnic/racial differences in body Fe store susceptibility may contribute to racial and geographic disparities in MetS.

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KW - Serum ferritin

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