Serum cytokine level fluctuations in chemotherapy-induced myelosuppression

Yuh Min Chen, Jacqueline Whang-Peng, Jacqueline Ming Liu, Benjamin Ing Tiau Kuo, Sheng Yuan Wang, Chun Ming Tsai, Reury Perng Perng

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines that function at different hematopoietic stages also fluctuate during chemotherapy-induced myelosuppression and whether the extent of cytokine level fluctuations correlate with myelosuppression severity. Fifteen patients participated in the study. Serum levels of stem cell factor (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyteitmacrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined. The results showed that both serum G-CSF and IL-6 levels rose in patients with chemotherapy-induced myelosuppression. The prechemotherapy serum G-CSF and IL-6 levels correlated well with their respective elevated levels during the myelosuppressive stage. The myelosuppression severity also correlated well with the extent of serum G-CSF level elevation. The serum IL-6 and G-CSF levels during the myelosuppressive stage correlated significantly. Serum SCF levels did not fluctuate significantly during myelosuppression, and IL-1, IL-3 and GM-CSF were rarely detected in serum even after chemotherapy. In the present study, the roles of IL-1α, SCF, IL-3 and GM-CSF chemotherapy-induced myelosuppression were not clear.

Original languageEnglish
Pages (from-to)18-23
Number of pages6
JournalJapanese Journal of Clinical Oncology
Volume26
Issue number1
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

Fingerprint

Granulocyte Colony-Stimulating Factor
Cytokines
Drug Therapy
Interleukin-6
Serum
Stem Cell Factor
Interleukin-3
Interleukin-1

Keywords

  • Granulocyte colony-stimulating factor
  • IL-3
  • IL-6
  • Interleukin-1α (IL-1α)
  • Stem cell factor

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Serum cytokine level fluctuations in chemotherapy-induced myelosuppression. / Chen, Yuh Min; Whang-Peng, Jacqueline; Liu, Jacqueline Ming; Kuo, Benjamin Ing Tiau; Wang, Sheng Yuan; Tsai, Chun Ming; Perng, Reury Perng.

In: Japanese Journal of Clinical Oncology, Vol. 26, No. 1, 01.01.1996, p. 18-23.

Research output: Contribution to journalArticle

Chen, Yuh Min ; Whang-Peng, Jacqueline ; Liu, Jacqueline Ming ; Kuo, Benjamin Ing Tiau ; Wang, Sheng Yuan ; Tsai, Chun Ming ; Perng, Reury Perng. / Serum cytokine level fluctuations in chemotherapy-induced myelosuppression. In: Japanese Journal of Clinical Oncology. 1996 ; Vol. 26, No. 1. pp. 18-23.
@article{604a4cf5201b4ecaa69e1fa7518d6c5c,
title = "Serum cytokine level fluctuations in chemotherapy-induced myelosuppression",
abstract = "We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines that function at different hematopoietic stages also fluctuate during chemotherapy-induced myelosuppression and whether the extent of cytokine level fluctuations correlate with myelosuppression severity. Fifteen patients participated in the study. Serum levels of stem cell factor (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyteitmacrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined. The results showed that both serum G-CSF and IL-6 levels rose in patients with chemotherapy-induced myelosuppression. The prechemotherapy serum G-CSF and IL-6 levels correlated well with their respective elevated levels during the myelosuppressive stage. The myelosuppression severity also correlated well with the extent of serum G-CSF level elevation. The serum IL-6 and G-CSF levels during the myelosuppressive stage correlated significantly. Serum SCF levels did not fluctuate significantly during myelosuppression, and IL-1, IL-3 and GM-CSF were rarely detected in serum even after chemotherapy. In the present study, the roles of IL-1α, SCF, IL-3 and GM-CSF chemotherapy-induced myelosuppression were not clear.",
keywords = "Granulocyte colony-stimulating factor, IL-3, IL-6, Interleukin-1α (IL-1α), Stem cell factor",
author = "Chen, {Yuh Min} and Jacqueline Whang-Peng and Liu, {Jacqueline Ming} and Kuo, {Benjamin Ing Tiau} and Wang, {Sheng Yuan} and Tsai, {Chun Ming} and Perng, {Reury Perng}",
year = "1996",
month = "1",
day = "1",
doi = "10.1093/oxfordjournals.jjco.a023173",
language = "English",
volume = "26",
pages = "18--23",
journal = "Japanese Journal of Clinical Oncology",
issn = "0368-2811",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Serum cytokine level fluctuations in chemotherapy-induced myelosuppression

AU - Chen, Yuh Min

AU - Whang-Peng, Jacqueline

AU - Liu, Jacqueline Ming

AU - Kuo, Benjamin Ing Tiau

AU - Wang, Sheng Yuan

AU - Tsai, Chun Ming

AU - Perng, Reury Perng

PY - 1996/1/1

Y1 - 1996/1/1

N2 - We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines that function at different hematopoietic stages also fluctuate during chemotherapy-induced myelosuppression and whether the extent of cytokine level fluctuations correlate with myelosuppression severity. Fifteen patients participated in the study. Serum levels of stem cell factor (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyteitmacrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined. The results showed that both serum G-CSF and IL-6 levels rose in patients with chemotherapy-induced myelosuppression. The prechemotherapy serum G-CSF and IL-6 levels correlated well with their respective elevated levels during the myelosuppressive stage. The myelosuppression severity also correlated well with the extent of serum G-CSF level elevation. The serum IL-6 and G-CSF levels during the myelosuppressive stage correlated significantly. Serum SCF levels did not fluctuate significantly during myelosuppression, and IL-1, IL-3 and GM-CSF were rarely detected in serum even after chemotherapy. In the present study, the roles of IL-1α, SCF, IL-3 and GM-CSF chemotherapy-induced myelosuppression were not clear.

AB - We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines that function at different hematopoietic stages also fluctuate during chemotherapy-induced myelosuppression and whether the extent of cytokine level fluctuations correlate with myelosuppression severity. Fifteen patients participated in the study. Serum levels of stem cell factor (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyteitmacrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined. The results showed that both serum G-CSF and IL-6 levels rose in patients with chemotherapy-induced myelosuppression. The prechemotherapy serum G-CSF and IL-6 levels correlated well with their respective elevated levels during the myelosuppressive stage. The myelosuppression severity also correlated well with the extent of serum G-CSF level elevation. The serum IL-6 and G-CSF levels during the myelosuppressive stage correlated significantly. Serum SCF levels did not fluctuate significantly during myelosuppression, and IL-1, IL-3 and GM-CSF were rarely detected in serum even after chemotherapy. In the present study, the roles of IL-1α, SCF, IL-3 and GM-CSF chemotherapy-induced myelosuppression were not clear.

KW - Granulocyte colony-stimulating factor

KW - IL-3

KW - IL-6

KW - Interleukin-1α (IL-1α)

KW - Stem cell factor

UR - http://www.scopus.com/inward/record.url?scp=0030075690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030075690&partnerID=8YFLogxK

U2 - 10.1093/oxfordjournals.jjco.a023173

DO - 10.1093/oxfordjournals.jjco.a023173

M3 - Article

VL - 26

SP - 18

EP - 23

JO - Japanese Journal of Clinical Oncology

JF - Japanese Journal of Clinical Oncology

SN - 0368-2811

IS - 1

ER -