Abstract
We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines that function at different hematopoietic stages also fluctuate during chemotherapy-induced myelosuppression and whether the extent of cytokine level fluctuations correlate with myelosuppression severity. Fifteen patients participated in the study. Serum levels of stem cell factor (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyteitmacrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined. The results showed that both serum G-CSF and IL-6 levels rose in patients with chemotherapy-induced myelosuppression. The prechemotherapy serum G-CSF and IL-6 levels correlated well with their respective elevated levels during the myelosuppressive stage. The myelosuppression severity also correlated well with the extent of serum G-CSF level elevation. The serum IL-6 and G-CSF levels during the myelosuppressive stage correlated significantly. Serum SCF levels did not fluctuate significantly during myelosuppression, and IL-1, IL-3 and GM-CSF were rarely detected in serum even after chemotherapy. In the present study, the roles of IL-1α, SCF, IL-3 and GM-CSF chemotherapy-induced myelosuppression were not clear.
Original language | English |
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Pages (from-to) | 18-23 |
Number of pages | 6 |
Journal | Japanese Journal of Clinical Oncology |
Volume | 26 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1 1996 |
Externally published | Yes |
Keywords
- Granulocyte colony-stimulating factor
- IL-3
- IL-6
- Interleukin-1α (IL-1α)
- Stem cell factor
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research