Abstract
We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines that function at different hematopoietic stages also fluctuate during chemotherapy-induced myelosuppression and whether the extent of cytokine level fluctuations correlate with myelosuppression severity. Fifteen patients participated in the study. Serum levels of stem cell factor (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyteitmacrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined. The results showed that both serum G-CSF and IL-6 levels rose in patients with chemotherapy-induced myelosuppression. The prechemotherapy serum G-CSF and IL-6 levels correlated well with their respective elevated levels during the myelosuppressive stage. The myelosuppression severity also correlated well with the extent of serum G-CSF level elevation. The serum IL-6 and G-CSF levels during the myelosuppressive stage correlated significantly. Serum SCF levels did not fluctuate significantly during myelosuppression, and IL-1, IL-3 and GM-CSF were rarely detected in serum even after chemotherapy. In the present study, the roles of IL-1α, SCF, IL-3 and GM-CSF chemotherapy-induced myelosuppression were not clear.
| Original language | English |
|---|---|
| Pages (from-to) | 18-23 |
| Number of pages | 6 |
| Journal | Japanese Journal of Clinical Oncology |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 1996 |
| Externally published | Yes |
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Keywords
- Granulocyte colony-stimulating factor
- IL-3
- IL-6
- Interleukin-1α (IL-1α)
- Stem cell factor
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research
Cite this
Serum cytokine level fluctuations in chemotherapy-induced myelosuppression. / Chen, Yuh Min; Whang-Peng, Jacqueline; Liu, Jacqueline Ming; Kuo, Benjamin Ing Tiau; Wang, Sheng Yuan; Tsai, Chun Ming; Perng, Reury Perng.
In: Japanese Journal of Clinical Oncology, Vol. 26, No. 1, 01.01.1996, p. 18-23.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum cytokine level fluctuations in chemotherapy-induced myelosuppression
AU - Chen, Yuh Min
AU - Whang-Peng, Jacqueline
AU - Liu, Jacqueline Ming
AU - Kuo, Benjamin Ing Tiau
AU - Wang, Sheng Yuan
AU - Tsai, Chun Ming
AU - Perng, Reury Perng
PY - 1996/1/1
Y1 - 1996/1/1
N2 - We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines that function at different hematopoietic stages also fluctuate during chemotherapy-induced myelosuppression and whether the extent of cytokine level fluctuations correlate with myelosuppression severity. Fifteen patients participated in the study. Serum levels of stem cell factor (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyteitmacrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined. The results showed that both serum G-CSF and IL-6 levels rose in patients with chemotherapy-induced myelosuppression. The prechemotherapy serum G-CSF and IL-6 levels correlated well with their respective elevated levels during the myelosuppressive stage. The myelosuppression severity also correlated well with the extent of serum G-CSF level elevation. The serum IL-6 and G-CSF levels during the myelosuppressive stage correlated significantly. Serum SCF levels did not fluctuate significantly during myelosuppression, and IL-1, IL-3 and GM-CSF were rarely detected in serum even after chemotherapy. In the present study, the roles of IL-1α, SCF, IL-3 and GM-CSF chemotherapy-induced myelosuppression were not clear.
AB - We have reported that serum granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) levels rise in patients with chemotherapy-induced myelosuppression. The aim of the present study was to determine whether other cytokines that function at different hematopoietic stages also fluctuate during chemotherapy-induced myelosuppression and whether the extent of cytokine level fluctuations correlate with myelosuppression severity. Fifteen patients participated in the study. Serum levels of stem cell factor (SCF), interleukin (IL)-1α, IL-6, IL-3, granulocyteitmacrophage CSF (GM-CSF) and G-CSF were analyzed before chemotherapy and during the myelosuppressive stage and correlations between cytokine levels and myelosuppression severity were examined. The results showed that both serum G-CSF and IL-6 levels rose in patients with chemotherapy-induced myelosuppression. The prechemotherapy serum G-CSF and IL-6 levels correlated well with their respective elevated levels during the myelosuppressive stage. The myelosuppression severity also correlated well with the extent of serum G-CSF level elevation. The serum IL-6 and G-CSF levels during the myelosuppressive stage correlated significantly. Serum SCF levels did not fluctuate significantly during myelosuppression, and IL-1, IL-3 and GM-CSF were rarely detected in serum even after chemotherapy. In the present study, the roles of IL-1α, SCF, IL-3 and GM-CSF chemotherapy-induced myelosuppression were not clear.
KW - Granulocyte colony-stimulating factor
KW - IL-3
KW - IL-6
KW - Interleukin-1α (IL-1α)
KW - Stem cell factor
UR - http://www.scopus.com/inward/record.url?scp=0030075690&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030075690&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.jjco.a023173
DO - 10.1093/oxfordjournals.jjco.a023173
M3 - Article
VL - 26
SP - 18
EP - 23
JO - Japanese Journal of Clinical Oncology
JF - Japanese Journal of Clinical Oncology
SN - 0368-2811
IS - 1
ER -