Abstract
BACKGROUND: Anti-Müllerian hormone (AMH) is reported to be a reliable marker of the ovarian response to controlled ovarian stimulation (COS). The objective of this study is to determine whether the serum AMH level can predict ovarian hyperstimulation syndrome (OHSS) prior to selection of COS protocols. METHODS: A cohort of 262 IVF cycles was investigated prospectively, in order to evaluate the predictive value for OHSS by means of certain risk factors, including age, body mass index (BMI), serum estradiol (E2) level, number of retrieved oocytes and basal serum AMH level. RESULTS: The basal serum AMH level predicted OHSS better than age and BMI with a sensitivity of 90.5% and specificity of 81.3%. Both the basal serum AMH level (odds ratio: 1.7856, P = 0.0003) and serum E2 level on the day of HCG administration (odds ratio: 1.0005, P = 0.0455) proved to be significant predictors of OHSS by logistic regression analysis. However, age (odds ratio: 0.9346, P = 0.049) was the only significant factor for prediction of clinical pregnancy. CONCLUSIONS: The basal serum AMH level could be utilized effectively to predict OHSS and thus to direct the selection of mild COS protocols.
| Original language | English |
|---|---|
| Pages (from-to) | 160-167 |
| Number of pages | 8 |
| Journal | Human Reproduction |
| Volume | 23 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2008 |
| Externally published | Yes |
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Keywords
- Anti-Müllerian hormone
- Controlled ovarian stimulation
- Estradiol
- Ovarian hyperstimulation syndrome
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology
Cite this
Serum anti-müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles. / Lee, Tsung Hsien; Liu, Chung Hsien; Huang, Chuin Chia; Wu, Yi Ling; Shih, Yang Tse; Ho, Hong Nerng; Yang, Yu Shih; Lee, Maw Shang.
In: Human Reproduction, Vol. 23, No. 1, 01.01.2008, p. 160-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum anti-müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles
AU - Lee, Tsung Hsien
AU - Liu, Chung Hsien
AU - Huang, Chuin Chia
AU - Wu, Yi Ling
AU - Shih, Yang Tse
AU - Ho, Hong Nerng
AU - Yang, Yu Shih
AU - Lee, Maw Shang
PY - 2008/1/1
Y1 - 2008/1/1
N2 - BACKGROUND: Anti-Müllerian hormone (AMH) is reported to be a reliable marker of the ovarian response to controlled ovarian stimulation (COS). The objective of this study is to determine whether the serum AMH level can predict ovarian hyperstimulation syndrome (OHSS) prior to selection of COS protocols. METHODS: A cohort of 262 IVF cycles was investigated prospectively, in order to evaluate the predictive value for OHSS by means of certain risk factors, including age, body mass index (BMI), serum estradiol (E2) level, number of retrieved oocytes and basal serum AMH level. RESULTS: The basal serum AMH level predicted OHSS better than age and BMI with a sensitivity of 90.5% and specificity of 81.3%. Both the basal serum AMH level (odds ratio: 1.7856, P = 0.0003) and serum E2 level on the day of HCG administration (odds ratio: 1.0005, P = 0.0455) proved to be significant predictors of OHSS by logistic regression analysis. However, age (odds ratio: 0.9346, P = 0.049) was the only significant factor for prediction of clinical pregnancy. CONCLUSIONS: The basal serum AMH level could be utilized effectively to predict OHSS and thus to direct the selection of mild COS protocols.
AB - BACKGROUND: Anti-Müllerian hormone (AMH) is reported to be a reliable marker of the ovarian response to controlled ovarian stimulation (COS). The objective of this study is to determine whether the serum AMH level can predict ovarian hyperstimulation syndrome (OHSS) prior to selection of COS protocols. METHODS: A cohort of 262 IVF cycles was investigated prospectively, in order to evaluate the predictive value for OHSS by means of certain risk factors, including age, body mass index (BMI), serum estradiol (E2) level, number of retrieved oocytes and basal serum AMH level. RESULTS: The basal serum AMH level predicted OHSS better than age and BMI with a sensitivity of 90.5% and specificity of 81.3%. Both the basal serum AMH level (odds ratio: 1.7856, P = 0.0003) and serum E2 level on the day of HCG administration (odds ratio: 1.0005, P = 0.0455) proved to be significant predictors of OHSS by logistic regression analysis. However, age (odds ratio: 0.9346, P = 0.049) was the only significant factor for prediction of clinical pregnancy. CONCLUSIONS: The basal serum AMH level could be utilized effectively to predict OHSS and thus to direct the selection of mild COS protocols.
KW - Anti-Müllerian hormone
KW - Controlled ovarian stimulation
KW - Estradiol
KW - Ovarian hyperstimulation syndrome
UR - http://www.scopus.com/inward/record.url?scp=40549085015&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40549085015&partnerID=8YFLogxK
U2 - 10.1093/humrep/dem254
DO - 10.1093/humrep/dem254
M3 - Article
VL - 23
SP - 160
EP - 167
JO - Human Reproduction
JF - Human Reproduction
SN - 0268-1161
IS - 1
ER -