Serum anti-müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles

Tsung Hsien Lee, Chung Hsien Liu, Chuin Chia Huang, Yi Ling Wu, Yang Tse Shih, Hong Nerng Ho, Yu Shih Yang, Maw Shang Lee

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

BACKGROUND: Anti-Müllerian hormone (AMH) is reported to be a reliable marker of the ovarian response to controlled ovarian stimulation (COS). The objective of this study is to determine whether the serum AMH level can predict ovarian hyperstimulation syndrome (OHSS) prior to selection of COS protocols. METHODS: A cohort of 262 IVF cycles was investigated prospectively, in order to evaluate the predictive value for OHSS by means of certain risk factors, including age, body mass index (BMI), serum estradiol (E2) level, number of retrieved oocytes and basal serum AMH level. RESULTS: The basal serum AMH level predicted OHSS better than age and BMI with a sensitivity of 90.5% and specificity of 81.3%. Both the basal serum AMH level (odds ratio: 1.7856, P = 0.0003) and serum E2 level on the day of HCG administration (odds ratio: 1.0005, P = 0.0455) proved to be significant predictors of OHSS by logistic regression analysis. However, age (odds ratio: 0.9346, P = 0.049) was the only significant factor for prediction of clinical pregnancy. CONCLUSIONS: The basal serum AMH level could be utilized effectively to predict OHSS and thus to direct the selection of mild COS protocols.

Original languageEnglish
Pages (from-to)160-167
Number of pages8
JournalHuman Reproduction
Volume23
Issue number1
DOIs
Publication statusPublished - Jan 1 2008
Externally publishedYes

Fingerprint

Ovarian Hyperstimulation Syndrome
Reproduction
Estradiol
Hormones
Technology
Serum
Ovulation Induction
Odds Ratio
Body Mass Index
Oocytes
Logistic Models
Regression Analysis
Sensitivity and Specificity
Pregnancy

Keywords

  • Anti-Müllerian hormone
  • Controlled ovarian stimulation
  • Estradiol
  • Ovarian hyperstimulation syndrome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Serum anti-müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles. / Lee, Tsung Hsien; Liu, Chung Hsien; Huang, Chuin Chia; Wu, Yi Ling; Shih, Yang Tse; Ho, Hong Nerng; Yang, Yu Shih; Lee, Maw Shang.

In: Human Reproduction, Vol. 23, No. 1, 01.01.2008, p. 160-167.

Research output: Contribution to journalArticle

Lee, Tsung Hsien ; Liu, Chung Hsien ; Huang, Chuin Chia ; Wu, Yi Ling ; Shih, Yang Tse ; Ho, Hong Nerng ; Yang, Yu Shih ; Lee, Maw Shang. / Serum anti-müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles. In: Human Reproduction. 2008 ; Vol. 23, No. 1. pp. 160-167.
@article{a3de171f76924f1591805d2c8921212d,
title = "Serum anti-m{\"u}llerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles",
abstract = "BACKGROUND: Anti-M{\"u}llerian hormone (AMH) is reported to be a reliable marker of the ovarian response to controlled ovarian stimulation (COS). The objective of this study is to determine whether the serum AMH level can predict ovarian hyperstimulation syndrome (OHSS) prior to selection of COS protocols. METHODS: A cohort of 262 IVF cycles was investigated prospectively, in order to evaluate the predictive value for OHSS by means of certain risk factors, including age, body mass index (BMI), serum estradiol (E2) level, number of retrieved oocytes and basal serum AMH level. RESULTS: The basal serum AMH level predicted OHSS better than age and BMI with a sensitivity of 90.5{\%} and specificity of 81.3{\%}. Both the basal serum AMH level (odds ratio: 1.7856, P = 0.0003) and serum E2 level on the day of HCG administration (odds ratio: 1.0005, P = 0.0455) proved to be significant predictors of OHSS by logistic regression analysis. However, age (odds ratio: 0.9346, P = 0.049) was the only significant factor for prediction of clinical pregnancy. CONCLUSIONS: The basal serum AMH level could be utilized effectively to predict OHSS and thus to direct the selection of mild COS protocols.",
keywords = "Anti-M{\"u}llerian hormone, Controlled ovarian stimulation, Estradiol, Ovarian hyperstimulation syndrome",
author = "Lee, {Tsung Hsien} and Liu, {Chung Hsien} and Huang, {Chuin Chia} and Wu, {Yi Ling} and Shih, {Yang Tse} and Ho, {Hong Nerng} and Yang, {Yu Shih} and Lee, {Maw Shang}",
year = "2008",
month = "1",
day = "1",
doi = "10.1093/humrep/dem254",
language = "English",
volume = "23",
pages = "160--167",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Serum anti-müllerian hormone and estradiol levels as predictors of ovarian hyperstimulation syndrome in assisted reproduction technology cycles

AU - Lee, Tsung Hsien

AU - Liu, Chung Hsien

AU - Huang, Chuin Chia

AU - Wu, Yi Ling

AU - Shih, Yang Tse

AU - Ho, Hong Nerng

AU - Yang, Yu Shih

AU - Lee, Maw Shang

PY - 2008/1/1

Y1 - 2008/1/1

N2 - BACKGROUND: Anti-Müllerian hormone (AMH) is reported to be a reliable marker of the ovarian response to controlled ovarian stimulation (COS). The objective of this study is to determine whether the serum AMH level can predict ovarian hyperstimulation syndrome (OHSS) prior to selection of COS protocols. METHODS: A cohort of 262 IVF cycles was investigated prospectively, in order to evaluate the predictive value for OHSS by means of certain risk factors, including age, body mass index (BMI), serum estradiol (E2) level, number of retrieved oocytes and basal serum AMH level. RESULTS: The basal serum AMH level predicted OHSS better than age and BMI with a sensitivity of 90.5% and specificity of 81.3%. Both the basal serum AMH level (odds ratio: 1.7856, P = 0.0003) and serum E2 level on the day of HCG administration (odds ratio: 1.0005, P = 0.0455) proved to be significant predictors of OHSS by logistic regression analysis. However, age (odds ratio: 0.9346, P = 0.049) was the only significant factor for prediction of clinical pregnancy. CONCLUSIONS: The basal serum AMH level could be utilized effectively to predict OHSS and thus to direct the selection of mild COS protocols.

AB - BACKGROUND: Anti-Müllerian hormone (AMH) is reported to be a reliable marker of the ovarian response to controlled ovarian stimulation (COS). The objective of this study is to determine whether the serum AMH level can predict ovarian hyperstimulation syndrome (OHSS) prior to selection of COS protocols. METHODS: A cohort of 262 IVF cycles was investigated prospectively, in order to evaluate the predictive value for OHSS by means of certain risk factors, including age, body mass index (BMI), serum estradiol (E2) level, number of retrieved oocytes and basal serum AMH level. RESULTS: The basal serum AMH level predicted OHSS better than age and BMI with a sensitivity of 90.5% and specificity of 81.3%. Both the basal serum AMH level (odds ratio: 1.7856, P = 0.0003) and serum E2 level on the day of HCG administration (odds ratio: 1.0005, P = 0.0455) proved to be significant predictors of OHSS by logistic regression analysis. However, age (odds ratio: 0.9346, P = 0.049) was the only significant factor for prediction of clinical pregnancy. CONCLUSIONS: The basal serum AMH level could be utilized effectively to predict OHSS and thus to direct the selection of mild COS protocols.

KW - Anti-Müllerian hormone

KW - Controlled ovarian stimulation

KW - Estradiol

KW - Ovarian hyperstimulation syndrome

UR - http://www.scopus.com/inward/record.url?scp=40549085015&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40549085015&partnerID=8YFLogxK

U2 - 10.1093/humrep/dem254

DO - 10.1093/humrep/dem254

M3 - Article

VL - 23

SP - 160

EP - 167

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 1

ER -