Serum adipocyte fatty acid-binding protein level is negatively associated with vascular reactivity index measured by digital thermal monitoring in kidney transplant patients

Tai Li Chen, Ming Che Lee, Ching Chung Ho, Bang Gee Hsu, Jen Pi Tsai

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Adipocyte fatty acid-binding protein (A-FABP) is abundantly found in mature adipocytes and is involved in cardiovascular disease. Our aim is to investigate the association between serum A-FABP levels and endothelial function among kidney transplant (KT) patients. Fasting blood samples were obtained from 80 KT patients. Serum A-FABP levels were measured using a commercially available enzyme immunoassay kit. Endothelial function and vascular reactivity index (VRI) were measured using digital thermal monitoring test. In this study, VRI < 1.0, VRI 1.0–1.9, and VRI ≥ 2.0 were defined as poor, intermediate, and good vascular reactivity, respectively. There were 12 (15.0%), 30 (37.5%), and 38 (47.5%) KT patients categorized as having poor, intermediate, and good vascular reactivity, respectively. Increased serum levels of alkaline phosphatase (p = 0.012), γ-glutamyltranspeptidase (GGT; p = 0.032), and A-FABP (p < 0.001) were associated with decreased vascular reactivity. Multivariable forward stepwise linear regression analysis revealed that age (β = −0.283, adjusted R2 change = 0.072; p = 0.003) and serum log-A-FABP level (β = −0.514, adjusted R2 change = 0.268; p < 0.001) were significantly associated with VRI values in KT patients. We concluded that serum fasting A-FABP level is negatively associated with VRI values and plays a role in endothelial dysfunction of KT patients.

Original languageEnglish
Article number159
JournalMetabolites
Volume9
Issue number8
DOIs
Publication statusPublished - Aug 2019
Externally publishedYes

Keywords

  • Adipocyte fatty acid-binding protein
  • Digital thermal monitoring test
  • Endothelial function
  • Kidney transplantation
  • Vascular reactivity index

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology

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