Serum β-carotene level, arsenic methylation capability, and incidence of skin cancer

Yu Mei Hsueh, Hung Yi Chiou, Ya Li Huang, Wen Lin Wu, Chuan Chieh Huang, Mo Hsiung Yang, Lan Chin Lue, Gwo Shing Chen, Chien Jen Chen

Research output: Contribution to journalArticle

178 Citations (Scopus)

Abstract

To elucidate the associations of arsenic-induced skin cancer with serum β-carotene level and arsenic methylation capability, a total of 654 residents of age 30 or older were recruited from three arseniasis- hyperendemic villages in Taiwan and regularly examined for skin lesions during the follow-up period. There were 33 cases affected with newly diagnosed skin cancer during the follow-up, giving an incidence of 14.74 per 1000 person-years. Although most study subjects had stopped consuming high- arsenic artesian well water more than 20 years ago, the risk of skin cancer was found to increase significantly with cumulative arsenic exposure before the cessation of drinking artesian well water in a dose-response relationship. Frozen serum samples collected at the recruitment from newly developed skin cancer cases and matched controls were tested for β-carotene levels by high-performance liquid chromatography. Frozen urine samples of these subjects wore examined by high-performance liquid chromatography to speciate arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMA), and dimethylarsinic acid and then quantitated by hydride generator combined with atomic absorption spectrometry. Skin cancer cases had a significantly lower serum level of 10-carotene than matched healthy controls. Although the primary methylation capability indexed by the ratio of MMA/(AsIII + AsV) was greater in cases than in controls, the secondary methylation capability indexed by the ratio of dimethylarsinic acid/MMA was lower in cases than in controls. An elevated proportion of MMA in total urinary arsenic level was associated with an increased risk of skin cancer. Subjects with a cumulative arsenic exposure of ≤20.0 mg/liter-year and a proportion of MMA in total urinary arsenic level >26.7% had a multivariate-adjusted odds ratio of developing skin cancer as high as 20.91 (95% confidence interval, 2.63166.5) compared with those who had a cumulative arsenic exposure of

Original languageEnglish
Pages (from-to)589-596
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume6
Issue number8
Publication statusPublished - 1997

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Arsenic
Skin Neoplasms
Carotenoids
Methylation
Incidence
Serum
Water Wells
Cacodylic Acid
High Pressure Liquid Chromatography
Water
Taiwan
Drinking
Spectrum Analysis
Odds Ratio
monomethylarsonic acid
Urine
Confidence Intervals
Skin

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Serum β-carotene level, arsenic methylation capability, and incidence of skin cancer. / Hsueh, Yu Mei; Chiou, Hung Yi; Huang, Ya Li; Wu, Wen Lin; Huang, Chuan Chieh; Yang, Mo Hsiung; Lue, Lan Chin; Chen, Gwo Shing; Chen, Chien Jen.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 6, No. 8, 1997, p. 589-596.

Research output: Contribution to journalArticle

Hsueh, Yu Mei ; Chiou, Hung Yi ; Huang, Ya Li ; Wu, Wen Lin ; Huang, Chuan Chieh ; Yang, Mo Hsiung ; Lue, Lan Chin ; Chen, Gwo Shing ; Chen, Chien Jen. / Serum β-carotene level, arsenic methylation capability, and incidence of skin cancer. In: Cancer Epidemiology Biomarkers and Prevention. 1997 ; Vol. 6, No. 8. pp. 589-596.
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