Abstract
Obstructive sleep apnea (OSA) is a highly prevalent disease which carries substantial public health burden. Polysomnography is the standard procedure used to diagnose OSA. However cost, accessibility, technical requirements, and skilled interpretation needs constrain its widespread use and have a role in the under-diagnosis of sleep disordered breathing. There is a clinical need to develop expedient and widely accessible tools to detect this disorder., Several biochemical markers have recently been proposed as diagnostic tools in OSA. Numerous neurochemicals directly influence the activity of upper airway dilator motor neurons, which subsequently influence respiration during sleep. Serotonin (5-HT) is one such neurochemical that has a key role in ventilatory stimulation. Herein, we review the current evidence demonstrating relationships between multiple biomarkers and sleep disordered breathing and focus on relationships between OSA and 5-HT. We discuss the possibility of biomarker-driven detection technology in the future as a means of diagnosing and monitoring OSA. Finally, we explore the specific role 5-HT may have in the future in both the diagnosis and treatment of OSA.
| Original language | English |
|---|---|
| Pages (from-to) | 121-128 |
| Number of pages | 8 |
| Journal | Sleep Medicine Reviews |
| Volume | 28 |
| DOIs | |
| Publication status | Published - Aug 1 2016 |
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Keywords
- Alternative OSA treatments
- Biomarkers
- Obstructive sleep apnea (OSA)
- Polysomnography
- Serotonin (5-HT)
- Sleep-disordered breathing
ASJC Scopus subject areas
- Clinical Neurology
- Physiology (medical)
- Pulmonary and Respiratory Medicine
- Neurology
Cite this
Serotnin as a possible biomarker in obstructive sleep apnea. / Lipford, Melissa C.; Ramar, Kannan; Liang, Yao Jen; Lin, Chii Wann; Chao, Yun Ting; An, Jen; Chiu, Chih Hsien; Tsai, Yi Ju; Shu, Chih Hung; Lee, Fei Peng; Chiang, Rayleigh Ping Ying.
In: Sleep Medicine Reviews, Vol. 28, 01.08.2016, p. 121-128.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serotnin as a possible biomarker in obstructive sleep apnea
AU - Lipford, Melissa C.
AU - Ramar, Kannan
AU - Liang, Yao Jen
AU - Lin, Chii Wann
AU - Chao, Yun Ting
AU - An, Jen
AU - Chiu, Chih Hsien
AU - Tsai, Yi Ju
AU - Shu, Chih Hung
AU - Lee, Fei Peng
AU - Chiang, Rayleigh Ping Ying
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Obstructive sleep apnea (OSA) is a highly prevalent disease which carries substantial public health burden. Polysomnography is the standard procedure used to diagnose OSA. However cost, accessibility, technical requirements, and skilled interpretation needs constrain its widespread use and have a role in the under-diagnosis of sleep disordered breathing. There is a clinical need to develop expedient and widely accessible tools to detect this disorder., Several biochemical markers have recently been proposed as diagnostic tools in OSA. Numerous neurochemicals directly influence the activity of upper airway dilator motor neurons, which subsequently influence respiration during sleep. Serotonin (5-HT) is one such neurochemical that has a key role in ventilatory stimulation. Herein, we review the current evidence demonstrating relationships between multiple biomarkers and sleep disordered breathing and focus on relationships between OSA and 5-HT. We discuss the possibility of biomarker-driven detection technology in the future as a means of diagnosing and monitoring OSA. Finally, we explore the specific role 5-HT may have in the future in both the diagnosis and treatment of OSA.
AB - Obstructive sleep apnea (OSA) is a highly prevalent disease which carries substantial public health burden. Polysomnography is the standard procedure used to diagnose OSA. However cost, accessibility, technical requirements, and skilled interpretation needs constrain its widespread use and have a role in the under-diagnosis of sleep disordered breathing. There is a clinical need to develop expedient and widely accessible tools to detect this disorder., Several biochemical markers have recently been proposed as diagnostic tools in OSA. Numerous neurochemicals directly influence the activity of upper airway dilator motor neurons, which subsequently influence respiration during sleep. Serotonin (5-HT) is one such neurochemical that has a key role in ventilatory stimulation. Herein, we review the current evidence demonstrating relationships between multiple biomarkers and sleep disordered breathing and focus on relationships between OSA and 5-HT. We discuss the possibility of biomarker-driven detection technology in the future as a means of diagnosing and monitoring OSA. Finally, we explore the specific role 5-HT may have in the future in both the diagnosis and treatment of OSA.
KW - Alternative OSA treatments
KW - Biomarkers
KW - Obstructive sleep apnea (OSA)
KW - Polysomnography
KW - Serotonin (5-HT)
KW - Sleep-disordered breathing
UR - http://www.scopus.com/inward/record.url?scp=84949684285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949684285&partnerID=8YFLogxK
U2 - 10.1016/j.smrv.2015.08.003
DO - 10.1016/j.smrv.2015.08.003
M3 - Article
C2 - 26694311
AN - SCOPUS:84949684285
VL - 28
SP - 121
EP - 128
JO - Sleep Medicine Reviews
JF - Sleep Medicine Reviews
SN - 1087-0792
ER -