Serotnin as a possible biomarker in obstructive sleep apnea

Melissa C. Lipford, Kannan Ramar, Yao Jen Liang, Chii Wann Lin, Yun Ting Chao, Jen An, Chih Hsien Chiu, Yi Ju Tsai, Chih Hung Shu, Fei Peng Lee, Rayleigh Ping Ying Chiang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Obstructive sleep apnea (OSA) is a highly prevalent disease which carries substantial public health burden. Polysomnography is the standard procedure used to diagnose OSA. However cost, accessibility, technical requirements, and skilled interpretation needs constrain its widespread use and have a role in the under-diagnosis of sleep disordered breathing. There is a clinical need to develop expedient and widely accessible tools to detect this disorder., Several biochemical markers have recently been proposed as diagnostic tools in OSA. Numerous neurochemicals directly influence the activity of upper airway dilator motor neurons, which subsequently influence respiration during sleep. Serotonin (5-HT) is one such neurochemical that has a key role in ventilatory stimulation. Herein, we review the current evidence demonstrating relationships between multiple biomarkers and sleep disordered breathing and focus on relationships between OSA and 5-HT. We discuss the possibility of biomarker-driven detection technology in the future as a means of diagnosing and monitoring OSA. Finally, we explore the specific role 5-HT may have in the future in both the diagnosis and treatment of OSA.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalSleep Medicine Reviews
Volume28
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Obstructive Sleep Apnea
Biomarkers
Serotonin
Sleep Apnea Syndromes
Polysomnography
Motor Neurons
Sleep
Respiration
Public Health
Technology
Costs and Cost Analysis

Keywords

  • Alternative OSA treatments
  • Biomarkers
  • Obstructive sleep apnea (OSA)
  • Polysomnography
  • Serotonin (5-HT)
  • Sleep-disordered breathing

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

Lipford, M. C., Ramar, K., Liang, Y. J., Lin, C. W., Chao, Y. T., An, J., ... Chiang, R. P. Y. (2016). Serotnin as a possible biomarker in obstructive sleep apnea. Sleep Medicine Reviews, 28, 121-128. https://doi.org/10.1016/j.smrv.2015.08.003

Serotnin as a possible biomarker in obstructive sleep apnea. / Lipford, Melissa C.; Ramar, Kannan; Liang, Yao Jen; Lin, Chii Wann; Chao, Yun Ting; An, Jen; Chiu, Chih Hsien; Tsai, Yi Ju; Shu, Chih Hung; Lee, Fei Peng; Chiang, Rayleigh Ping Ying.

In: Sleep Medicine Reviews, Vol. 28, 01.08.2016, p. 121-128.

Research output: Contribution to journalArticle

Lipford, MC, Ramar, K, Liang, YJ, Lin, CW, Chao, YT, An, J, Chiu, CH, Tsai, YJ, Shu, CH, Lee, FP & Chiang, RPY 2016, 'Serotnin as a possible biomarker in obstructive sleep apnea', Sleep Medicine Reviews, vol. 28, pp. 121-128. https://doi.org/10.1016/j.smrv.2015.08.003
Lipford MC, Ramar K, Liang YJ, Lin CW, Chao YT, An J et al. Serotnin as a possible biomarker in obstructive sleep apnea. Sleep Medicine Reviews. 2016 Aug 1;28:121-128. https://doi.org/10.1016/j.smrv.2015.08.003
Lipford, Melissa C. ; Ramar, Kannan ; Liang, Yao Jen ; Lin, Chii Wann ; Chao, Yun Ting ; An, Jen ; Chiu, Chih Hsien ; Tsai, Yi Ju ; Shu, Chih Hung ; Lee, Fei Peng ; Chiang, Rayleigh Ping Ying. / Serotnin as a possible biomarker in obstructive sleep apnea. In: Sleep Medicine Reviews. 2016 ; Vol. 28. pp. 121-128.
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