Seroprevalence of herpes simplex virus type 1 and 2 in Taiwan and risk factor analysis, 2007

Jen Hsiang Shen, Kuan Ying Arthur Huang, Chen Chao-Yu, Chih Jung Chen, Tzou Yien Lin, Yhu Chering Huang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) are common human pathogens and might cause severe illness. Following primary infection, the viruses establish lifelong latent infection and are transmitted by close contact, both sexual and nonsexual. However, the information about the seroprevalence of HSV-1 and HSV-2 across all age groups is limited. Methods: Residual sera collected during the nationwide serosurvey in 2007 in Taiwan were selected for the study. The enzyme-linked immunosorbent assay was used to detect anti-HSV-1 and anti-HSV-2 type-specific glycoprotein IgG. Demographics and personal health data were used for risk analysis. Results: A total of 1411 and 1072 serum samples were included for anti-HSV-1 and anti-HSV-2 seroprevalence analysis, respectively. The weighted overall seroprevalence was 63.2% for HSV-1, and 7.7% for HSV-2, respectively. The HSV-1 seropositive rate was 19.2% for those less than 5 years old, increased to 46.4% for those aged 5-13 years, 60.9% for those aged 14-29 years, and reached as much as 95.0% for those aged over 30 years. In contrast, the HSV-2 seropositve rate was 1.6% for those less than 30 years old, rose to 10.1% for those age 30-39 years, and was up to 31.2% for those aged over 60 years. A significantly higher HSV-2 seropositive rate was noted in females than males aged over 40 years (26.3% v.s. 16.8%), and the overall HSV-2 seropositive rate was almost twice higher in females than males. Smoking history, drinking habit, and educational level were associated with the HSV-1 seropositivity. Female gender and rural residence were independent factors for the HSV-2 seropositivity. Conclusions: An obvious increase of primary HSV-1 infection occurred in late adolescents and young adults, joined by the rise of HSV-2 infection in middle-aged adults, especially females. The acquistion and transmission of HSV warrant further studies in the susceptible population.

Original languageEnglish
Article numbere0134178
JournalPLoS One
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 7 2015
Externally publishedYes

Fingerprint

Human herpesvirus 2
Human herpesvirus 1
Human Herpesvirus 2
Seroepidemiologic Studies
Human Herpesvirus 1
Factor analysis
Taiwan
Viruses
seroprevalence
Statistical Factor Analysis
risk factors
infection
middle-aged adults
factor analysis
risk analysis
Immunosorbents
educational status
at-risk population
drinking
young adults

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Seroprevalence of herpes simplex virus type 1 and 2 in Taiwan and risk factor analysis, 2007. / Shen, Jen Hsiang; Huang, Kuan Ying Arthur; Chao-Yu, Chen; Chen, Chih Jung; Lin, Tzou Yien; Huang, Yhu Chering.

In: PLoS One, Vol. 10, No. 8, e0134178, 07.08.2015.

Research output: Contribution to journalArticle

Shen, Jen Hsiang ; Huang, Kuan Ying Arthur ; Chao-Yu, Chen ; Chen, Chih Jung ; Lin, Tzou Yien ; Huang, Yhu Chering. / Seroprevalence of herpes simplex virus type 1 and 2 in Taiwan and risk factor analysis, 2007. In: PLoS One. 2015 ; Vol. 10, No. 8.
@article{a06827b45bf240979aade635d7e2aade,
title = "Seroprevalence of herpes simplex virus type 1 and 2 in Taiwan and risk factor analysis, 2007",
abstract = "Background: Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) are common human pathogens and might cause severe illness. Following primary infection, the viruses establish lifelong latent infection and are transmitted by close contact, both sexual and nonsexual. However, the information about the seroprevalence of HSV-1 and HSV-2 across all age groups is limited. Methods: Residual sera collected during the nationwide serosurvey in 2007 in Taiwan were selected for the study. The enzyme-linked immunosorbent assay was used to detect anti-HSV-1 and anti-HSV-2 type-specific glycoprotein IgG. Demographics and personal health data were used for risk analysis. Results: A total of 1411 and 1072 serum samples were included for anti-HSV-1 and anti-HSV-2 seroprevalence analysis, respectively. The weighted overall seroprevalence was 63.2{\%} for HSV-1, and 7.7{\%} for HSV-2, respectively. The HSV-1 seropositive rate was 19.2{\%} for those less than 5 years old, increased to 46.4{\%} for those aged 5-13 years, 60.9{\%} for those aged 14-29 years, and reached as much as 95.0{\%} for those aged over 30 years. In contrast, the HSV-2 seropositve rate was 1.6{\%} for those less than 30 years old, rose to 10.1{\%} for those age 30-39 years, and was up to 31.2{\%} for those aged over 60 years. A significantly higher HSV-2 seropositive rate was noted in females than males aged over 40 years (26.3{\%} v.s. 16.8{\%}), and the overall HSV-2 seropositive rate was almost twice higher in females than males. Smoking history, drinking habit, and educational level were associated with the HSV-1 seropositivity. Female gender and rural residence were independent factors for the HSV-2 seropositivity. Conclusions: An obvious increase of primary HSV-1 infection occurred in late adolescents and young adults, joined by the rise of HSV-2 infection in middle-aged adults, especially females. The acquistion and transmission of HSV warrant further studies in the susceptible population.",
author = "Shen, {Jen Hsiang} and Huang, {Kuan Ying Arthur} and Chen Chao-Yu and Chen, {Chih Jung} and Lin, {Tzou Yien} and Huang, {Yhu Chering}",
year = "2015",
month = "8",
day = "7",
doi = "10.1371/journal.pone.0134178",
language = "English",
volume = "10",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

TY - JOUR

T1 - Seroprevalence of herpes simplex virus type 1 and 2 in Taiwan and risk factor analysis, 2007

AU - Shen, Jen Hsiang

AU - Huang, Kuan Ying Arthur

AU - Chao-Yu, Chen

AU - Chen, Chih Jung

AU - Lin, Tzou Yien

AU - Huang, Yhu Chering

PY - 2015/8/7

Y1 - 2015/8/7

N2 - Background: Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) are common human pathogens and might cause severe illness. Following primary infection, the viruses establish lifelong latent infection and are transmitted by close contact, both sexual and nonsexual. However, the information about the seroprevalence of HSV-1 and HSV-2 across all age groups is limited. Methods: Residual sera collected during the nationwide serosurvey in 2007 in Taiwan were selected for the study. The enzyme-linked immunosorbent assay was used to detect anti-HSV-1 and anti-HSV-2 type-specific glycoprotein IgG. Demographics and personal health data were used for risk analysis. Results: A total of 1411 and 1072 serum samples were included for anti-HSV-1 and anti-HSV-2 seroprevalence analysis, respectively. The weighted overall seroprevalence was 63.2% for HSV-1, and 7.7% for HSV-2, respectively. The HSV-1 seropositive rate was 19.2% for those less than 5 years old, increased to 46.4% for those aged 5-13 years, 60.9% for those aged 14-29 years, and reached as much as 95.0% for those aged over 30 years. In contrast, the HSV-2 seropositve rate was 1.6% for those less than 30 years old, rose to 10.1% for those age 30-39 years, and was up to 31.2% for those aged over 60 years. A significantly higher HSV-2 seropositive rate was noted in females than males aged over 40 years (26.3% v.s. 16.8%), and the overall HSV-2 seropositive rate was almost twice higher in females than males. Smoking history, drinking habit, and educational level were associated with the HSV-1 seropositivity. Female gender and rural residence were independent factors for the HSV-2 seropositivity. Conclusions: An obvious increase of primary HSV-1 infection occurred in late adolescents and young adults, joined by the rise of HSV-2 infection in middle-aged adults, especially females. The acquistion and transmission of HSV warrant further studies in the susceptible population.

AB - Background: Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) are common human pathogens and might cause severe illness. Following primary infection, the viruses establish lifelong latent infection and are transmitted by close contact, both sexual and nonsexual. However, the information about the seroprevalence of HSV-1 and HSV-2 across all age groups is limited. Methods: Residual sera collected during the nationwide serosurvey in 2007 in Taiwan were selected for the study. The enzyme-linked immunosorbent assay was used to detect anti-HSV-1 and anti-HSV-2 type-specific glycoprotein IgG. Demographics and personal health data were used for risk analysis. Results: A total of 1411 and 1072 serum samples were included for anti-HSV-1 and anti-HSV-2 seroprevalence analysis, respectively. The weighted overall seroprevalence was 63.2% for HSV-1, and 7.7% for HSV-2, respectively. The HSV-1 seropositive rate was 19.2% for those less than 5 years old, increased to 46.4% for those aged 5-13 years, 60.9% for those aged 14-29 years, and reached as much as 95.0% for those aged over 30 years. In contrast, the HSV-2 seropositve rate was 1.6% for those less than 30 years old, rose to 10.1% for those age 30-39 years, and was up to 31.2% for those aged over 60 years. A significantly higher HSV-2 seropositive rate was noted in females than males aged over 40 years (26.3% v.s. 16.8%), and the overall HSV-2 seropositive rate was almost twice higher in females than males. Smoking history, drinking habit, and educational level were associated with the HSV-1 seropositivity. Female gender and rural residence were independent factors for the HSV-2 seropositivity. Conclusions: An obvious increase of primary HSV-1 infection occurred in late adolescents and young adults, joined by the rise of HSV-2 infection in middle-aged adults, especially females. The acquistion and transmission of HSV warrant further studies in the susceptible population.

UR - http://www.scopus.com/inward/record.url?scp=84941985306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941985306&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0134178

DO - 10.1371/journal.pone.0134178

M3 - Article

C2 - 26252011

AN - SCOPUS:84941985306

VL - 10

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

M1 - e0134178

ER -