Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan

Yu Jiun Chan, Chia Ling Lee, Shinn Jang Hwang, Chang Phone Fung, Fu Der Wang, David H.T. Yen, Cheng Hsien Tsai, Yi Ming Arthur Chen, Shou Dong Lee

Research output: Contribution to journalArticle

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Abstract

Background: The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline sero-prevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population. Methods: A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titer ≥ 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups. Results: The mean ages and sex ratio (% male) of the hospital staff and control groups were 36.9 ± 10.6 years and 52.0 ± 12.6 years, and 24.4% and 57.6%, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0% vs. 2.9%, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8% vs. 12.6%, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group (p = 0.925). Conclusion: The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first.

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalJournal of the Chinese Medical Association
Volume73
Issue number2
DOIs
Publication statusPublished - Feb 1 2010
Externally publishedYes

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Seroepidemiologic Studies
Pandemics
Orthomyxoviridae
Taiwan
H1N1 Subtype Influenza A Virus
Antibodies
Control Groups
Hemagglutination Inhibition Tests
Immunization Programs
Sex Ratio
Hemagglutination
Serum
Human Influenza
Population
Antiviral Agents
Vaccination

Keywords

  • H1N1 influenza virus
  • hemagglutination-inhibition test
  • hospital staff
  • vaccination

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan. / Chan, Yu Jiun; Lee, Chia Ling; Hwang, Shinn Jang; Fung, Chang Phone; Wang, Fu Der; Yen, David H.T.; Tsai, Cheng Hsien; Chen, Yi Ming Arthur; Lee, Shou Dong.

In: Journal of the Chinese Medical Association, Vol. 73, No. 2, 01.02.2010, p. 62-66.

Research output: Contribution to journalArticle

Chan, Yu Jiun ; Lee, Chia Ling ; Hwang, Shinn Jang ; Fung, Chang Phone ; Wang, Fu Der ; Yen, David H.T. ; Tsai, Cheng Hsien ; Chen, Yi Ming Arthur ; Lee, Shou Dong. / Seroprevalence of Antibodies to Pandemic (H1N1) 2009 Influenza Virus Among Hospital Staff in a Medical Center in Taiwan. In: Journal of the Chinese Medical Association. 2010 ; Vol. 73, No. 2. pp. 62-66.
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abstract = "Background: The pandemic (H1N1) 2009 influenza emerged in April 2009 and spread rapidly and broadly all over the world. In addition to specific antiviral agents, massive vaccination is thought to be the most effective way of controlling the transmission. To understand the prevaccination status of certain risk groups, this study compared the baseline sero-prevalence of antibodies to the pandemic (H1N1) 2009 influenza virus among hospital staff with different contact risks and that of the general population. Methods: A total of 295 serum samples from hospital staff and 244 control serum samples from people who came for physical check-up (control group) were collected between October 2009 and November 2009 before the massive vaccination campaign. The hospital staff was divided into first-line risk personnel (group 1) and second-line risk personnel (group 2) according to their potential contact risks. Hemagglutination-inhibition (HI) tests were conducted to determine the individual serological status. The seropositive rate (SPR, defined as the proportion with HI titer ≥ 1:40) of antibodies to H1N1 influenza virus and its geometric mean titer (GMT) were calculated and compared among the different groups. Results: The mean ages and sex ratio ({\%} male) of the hospital staff and control groups were 36.9 ± 10.6 years and 52.0 ± 12.6 years, and 24.4{\%} and 57.6{\%}, respectively. The SPR of the antibodies to H1N1 influenza virus of the hospital staff was significantly higher than that of the control group (20.0{\%} vs. 2.9{\%}, p < 0.001). Furthermore, the SPR antibodies to H1N1 influenza virus of group 1 were significantly higher than that of group 2 (30.8{\%} vs. 12.6{\%}, p < 0.001). However, the GMT of antibodies to H1N1 influenza virus of the hospital staff was not significantly different from that of the control group (p = 0.925). Conclusion: The SPR of antibodies against the pandemic (H1N1) 2009 virus in the hospital staff was higher than that in the general population, reflecting a higher contact risk. Prevaccination surveillance of the immune status of different risk groups may help to prioritize which groups should be vaccinated first.",
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AU - Fung, Chang Phone

AU - Wang, Fu Der

AU - Yen, David H.T.

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